Category: 3939-14-8

Modulation of the fluorescence properties of diketopyrrolopyrroles via various electron-rich substituents was written by Purc, Anna;Banasiewicz, Marzena;Glodkowska-Mrowka, Eliza;Gryko, Daniel T.. And the article was included in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2016.COA of Formula: C6H3FN2 This article mentions the following:

Four diketopyrrolopyrroles have been synthesized starting from heterocyclic aromatic nitriles. It was found that the neg. influence of electron-donating groups on the reactivity of nitriles can be overcome by the presence of an electron-deficient pyridine ring. The absorption and emission properties of the diketopyrrolopyrroles and their N-substituted derivatives were evaluated in a range of solvents revealing that the exact position of the electron-donating substituents significantly modulated their fluorescence response. The presence of a dialkylamino moiety at position 3 of the aryl substituents led to the occurrence of very fast nonradiative deactivation processes. Formation of both the anion (located on the core) and cation (located on the pyridine ring) changes the relative energy of the excited states leading to strong red fluorescence. On the other hand, the presence of a pyrrole moiety at position 4 of the aryl substituents resulted in a record high fluorescence quantum yield (0.88). The combination of the two dialkylamino-pyridine moieties and the oligoethylene glycol substituent made it possible to obtain a compound possessing reasonable water-solubility, which was applied in fluorescence microscopy for the selective staining of mitochondria in living cells. In the experiment, the researchers used many compounds, for example, 2-Fluoroisonicotinonitrile (cas: 3939-14-8COA of Formula: C6H3FN2).

2-Fluoroisonicotinonitrile (cas: 3939-14-8) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.COA of Formula: C6H3FN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Arylation of benzyl amines with aromatic nitriles was written by Lei, Yingjie;Yang, Ju;Qi, Rupeng;Wang, Shan;Wang, Rui;Xu, Zhaoqing. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Recommanded Product: 3939-14-8 This article mentions the following:

Radical arylations using aromatic nitriles without the assistance of photoirradn was developed. Importantly, with this method, the direct arylation of C(sp³)-H in benzyl amines provided a practical method for the synthesis of diarylmethylamines I [R = H, CN; R¹ = H, F, 4-MeOC₆H₄, etc.; Ar = Ph, 4-ClC₆H₄, 2-furyl, etc.; X = C-R, N; R = H, CN] without the use of precious transition metal catalysts. In the experiment, the researchers used many compounds, for example, 2-Fluoroisonicotinonitrile (cas: 3939-14-8Recommanded Product: 3939-14-8).

2-Fluoroisonicotinonitrile (cas: 3939-14-8) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Recommanded Product: 3939-14-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators was written by Sharma, Swagat;Kozek, Krystian A.;Abney, Kristopher K.;Kumar, Sushil;Gautam, Nagsen;Alnouti, Yazen;David Weaver, C.;Hopkins, Corey R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2019.Category: pyridine-derivatives This article mentions the following:

The study described the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-yl acetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, a tetrazole scaffold was identified that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, the compounds were evaluated in Tier 1 DMPK assays and identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups. In the experiment, the researchers used many compounds, for example, 2-Fluoroisonicotinonitrile (cas: 3939-14-8Category: pyridine-derivatives).

2-Fluoroisonicotinonitrile (cas: 3939-14-8) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Photoredox-catalyzed branch-selective pyridylation of alkenes for the expedient synthesis of Triprolidine was written by Zhu, Shengqing;Qin, Jian;Wang, Fang;Li, Huan;Chu, Lingling. And the article was included in Nature Communications in 2019.Quality Control of 2-Fluoroisonicotinonitrile This article mentions the following:

A catalytic, branch-selective pyridylation of alkenes via a sulfinate assisted photoredox catalysis was reported. This reaction proceeded through a sequential radical addition/coupling/elimination, by utilizing readily available sodium sulfinates as reusable radical precursors as well as traceless elimination groups. This versatile protocol allows for the installation of important vinylpyridines with complete branched selectivity under mild conditions. Furthermore, this catalytic manifold was successfully applied to the expedient synthesis of Triprolidine. In the experiment, the researchers used many compounds, for example, 2-Fluoroisonicotinonitrile (cas: 3939-14-8Quality Control of 2-Fluoroisonicotinonitrile).

2-Fluoroisonicotinonitrile (cas: 3939-14-8) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Quality Control of 2-Fluoroisonicotinonitrile

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Metal-Free Synthesis of C-4 Substituted Pyridine Derivatives Using Pyridine-boryl Radicals via a Radical Addition/Coupling Mechanism: A Combined Computational and Experimental Study was written by Wang, Guoqiang;Cao, Jia;Gao, Liuzhou;Chen, Wenxin;Huang, Wenhao;Cheng, Xu;Li, Shuhua. And the article was included in Journal of the American Chemical Society in 2017.Formula: C6H3FN2 This article mentions the following:

D. functional theory investigations revealed that the pyridine-boryl radical generated in situ using 4-cyanopyridine and bis(pinacolato)diboron could be used as a bifunctional “reagent”, which serves as not only a pyridine precursor but also a boryl radical. With the unique reactivity of such radicals, 4-substituted pyridine derivatives could be synthesized using α,β-unsaturated ketones and 4-cyanopyridine via a novel radical addition/C-C coupling mechanism. Several controlled experiments were conducted to provide supportive evidence for the proposed mechanism. In addition to enones, the scope could be extended to a wide range of boryl radical acceptors, including various aldehydes and ketones, aryl imines and alkynones. Lastly, this transformation was applied in the late-stage modification of a complicated pharmaceutical mol. In the experiment, the researchers used many compounds, for example, 2-Fluoroisonicotinonitrile (cas: 3939-14-8Formula: C6H3FN2).

2-Fluoroisonicotinonitrile (cas: 3939-14-8) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Formula: C6H3FN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reactions of 4-aminopyridine with nitrous acid. VIII. 2-Fluoro-4-aminopyridine and 3-fluoro-4-aminopyridine was written by Talik, Tadeusz;Talik, Zofia. And the article was included in Roczniki Chemii in 1968.Related Products of 3939-14-8 This article mentions the following:

The fluorine atom in the 2 or 3 position of the pyridine ring exercised a weaker stabilizing influence on the diazonium group in position 4 than the Cl atom. Several products from reaction of diazonium compounds prepared from 2-fluoro-4-aminopyridine (I) and 3-fluoro-4-aminopyridine were obtained. Thus, a solution of 0.5 g. I in 5 ml. dilute H2SO4 (1:4) was diazotized at 0° with 0.9 g. NaNO2 in 3 ml. water. The mixture kept 20 min. at room temperature, diluted with 5 ml. H2O and refluxed for a few min., was neutralized with NH4OH to pH 5-6 and extracted with Et2O to give 0.4 g. 2-fluoro-4-hydroxypyridine, m. 157° (H2O). Similarly prepared were 88.1% 2-fluoro-4-iodopyridine, m. 58°, and 41.3% 2-fluoro-4-cyanopyridine (II), m. 31-2°. Hydrolysis of II with dilute HCl (1:1) yielded 86.8% 2-hydroxy-4-pyridinecarboxylic acid, m. 328° (H2O). The following compounds were reported (m.p., b.p., % yield, and m.p. picrate given): 3-fluoro-4-hydroxypyridine, 153°, -, 58.1, -; 3-fluoro-4-chloropyridine, -, 138°, 42.9, 134°; 3-fluoro-4-bromopyridine, -, 163°, 25.5, 115°; 3-fluoro-4-iodopyridine, 87°, -, 25.1, 140°. In the experiment, the researchers used many compounds, for example, 2-Fluoroisonicotinonitrile (cas: 3939-14-8Related Products of 3939-14-8).

2-Fluoroisonicotinonitrile (cas: 3939-14-8) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Related Products of 3939-14-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem