Category: 396092-82-3

Watanabe, Hiroyuki; Tatsumi, Haruka; Kaide, Sho; Shimizu, Yoichi; Iikuni, Shimpei; Ono, Masahiro published the artcile< Structure-Activity Relationships of Radioiodinated 6,5,6-Tricyclic Compounds for the Development of Tau Imaging Probes>, Recommanded Product: 2-Bromo-N,N-dimethylpyridin-4-amine, the main research area is structure radioiodinated tricyclic compound Tau imaging probe.

Tau aggregate, which is the main component of the neurofibrillary tangle, is an attractive imaging target for diagnosing and monitoring the progression of Alzheimer’s disease (AD). In this study, we designed and synthesized six radioiodinated 6,5,6-tricyclic compounds to explore novel scaffolds for tau imaging probes. On in vitro autoradiog. of AD brain sections, pyridoimidazopyridine and benzimidazopyrimidine derivatives ([125I]21 and [125I]22, resp.) showed selective binding affinity for tau aggregates, whereas carbazole, pyrrolodipyridine, and pyridoimidazopyrimidine derivatives ([125I]10, [125I]12, and [125I]23, resp.) bound β-amyloid aggregates. In a biodistribution study using normal mice, [125I]21 and [125I]22 showed high initial uptakes (5.73 and 5.66% ID/g, resp., at 2 min postinjection) into and rapid washout (0.14 and 0.10% ID/g, resp., at 60 min postinjection) from the brain. Taken together, two novel scaffolds including pyridoimidazopyridine and benzimidazopyrimidine may be applied to develop useful tau imaging probes.

ACS Medicinal Chemistry Letters published new progress about Alzheimer disease (potential diagnosis). 396092-82-3 belongs to class pyridine-derivatives, and the molecular formula is C7H9BrN2, Recommanded Product: 2-Bromo-N,N-dimethylpyridin-4-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Schmid, Lucius; Glaser, Felix; Schaer, Raoul; Wenger, Oliver S. published the artcile< High Triplet Energy Iridium(III) Isocyanoborato Complex for Photochemical Upconversion, Photoredox and Energy Transfer Catalysis>, Quality Control of 396092-82-3, the main research area is photochem upconversion photoredox energy transfer catalysis; High Triplet Energy Iridium Isocyanoborato Complex.

Cyclometalated Ir(III) complexes are often chosen as catalysts for challenging photoredox and triplet-triplet-energy-transfer (TTET) catalyzed reactions, and they are of interest for upconversion into the UV spectral range. However, the triplet energies of commonly employed Ir(III) photosensitizers are typically limited to values around 2.5-2.75 eV. Here, we report on a new Ir(III) luminophore, with an unusually high triplet energy near 3.0 eV owing to the modification of a previously reported Ir(III) complex with isocyanoborato ligands. Compared to a nonborylated cyanido precursor complex, the introduction of B(C6F5)3 units in the second coordination sphere results in substantially improved photophys. properties, in particular a high luminescence quantum yield (0.87) and a long excited-state lifetime (13.0 μs), in addition to the high triplet energy. These favorable properties (including good long-term photostability) facilitate exceptionally challenging organic triplet photoreactions and (sensitized) triplet-triplet annihilation upconversion to a fluorescent singlet excited state beyond 4 eV, unusually deep in the UV region. The new Ir(III) complex photocatalyzes a sigmatropic shift and [2 + 2] cycloaddition reactions that are unattainable with common transition metal-based photosensitizers. In the presence of a sacrificial electron donor, it furthermore is applicable to demanding photoreductions, including dehalogenations, detosylations, and the degradation of a lignin model substrate. Our study demonstrates how rational ligand design of transition-metal complexes (including underexplored second coordination sphere effects) can be used to enhance their photophys. properties and thereby broaden their application potential in solar energy conversion and synthetic photochem.

Journal of the American Chemical Society published new progress about [2+2] Cycloaddition reaction. 396092-82-3 belongs to class pyridine-derivatives, and the molecular formula is C7H9BrN2, Quality Control of 396092-82-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Parada, Giovanny A.; Goldsmith, Zachary K.; Kolmar, Scott; Pettersson Rimgard, Belinda; Mercado, Brandon Q.; Hammarstroem, Leif; Hammes-Schiffer, Sharon; Mayer, James M. published the artcile< Concerted proton-electron transfer reactions in the Marcus inverted region>, Reference of 396092-82-3, the main research area is concerted proton electron transfer reaction Marcus inverted region.

One of the most counterintuitive features of electron transfer kinetics is the inverted region. As Marcus theory predicts and experiments have borne out, electron transfer slows down once the driving force for it becomes especially favorable. Parada et al. now offer evidence for such inverted behavior in proton-coupled electron transfer. Specifically, they examined a series of compounds with phenol bridging anthracene (electron acceptor) and pyridine (proton acceptor) derivatives Time-resolved spectroscopy and accompanying theory revealed slower rates at higher driving forces in the back reaction that follows light-induced intramol. proton and electron transfer.

Science (Washington, DC, United States) published new progress about Charge separation. 396092-82-3 belongs to class pyridine-derivatives, and the molecular formula is C7H9BrN2, Reference of 396092-82-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Shengdong; Huang, Haiyun; Roisnel, Thierry; Bruneau, Christian; Fischmeister, Cedric published the artcile< Base-Free Dehydrogenation of Aqueous and Neat Formic Acid with Iridium(III) Cp*(dipyridylamine) Catalysts>, Safety of 2-Bromo-N,N-dimethylpyridin-4-amine, the main research area is preparation crystal structure iridium cyclopentadiynyl dipyridylamine complex; cyclic voltammetry iridium cyclopentadiynyl dipyridylamine complex; Dehydrogenation formic acid iridium cyclopentadiynyl dipyridylamine complex catalyst; N ligands; dehydrogenation; energy conversion; hydrogen; iridium.

The selective dehydrogenation of formic acid by iridium(III) Cp*(dipyridylamine) catalysts is reported. The electron-enriched catalyst [IrIIICp*{(4-dimethylaminopyridin-2-yl-κN)(pyridin-2′-yl-κN)amine}(OSO3)] gave the best performances enabling the base free dehydrogenation of aqueous and neat formic acid. In both cases the reaction was selective with no carbon monoxide detectable. The IrIII complex demonstrated latent behavior, which may be of practical utility. Exptl. results suggest an outer-sphere interaction with the ligand.

ChemSusChem published new progress about Crystal structure. 396092-82-3 belongs to class pyridine-derivatives, and the molecular formula is C7H9BrN2, Safety of 2-Bromo-N,N-dimethylpyridin-4-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Miller, Susanne L.; Chotana, Ghayoor A.; Fritz, Jonathan A.; Chattopadhyay, Buddhadeb; Maleczka, Robert E. Jr.; Smith, Milton R. III published the artcile< C-H Borylation Catalysts that Distinguish Between Similarly Sized Substituents Like Fluorine and Hydrogen>, Product Details of C7H9BrN2, the main research area is aromatic compound carbon hydrogen bond activation borylation iridium catalyst; borane heteroaryl derivative preparation.

By modifying ligand steric and electronic profiles it is possible to C-H borylate ortho or meta to substituents in aromatic and heteroaromatic compounds, where steric differences between accessible C-H sites are small. Dramatic effects on selectivities between reactions using B2pin2 or 4,4,5,5-tetramethyl-1,3,2-dioxaborolane (HBpin) are described for the 1st time. Judicious ligand and borane combinations give highly regioselective C-H borylations on substrates where typical borylation protocols afford poor selectivities.

Organic Letters published new progress about Boranes Role: SPN (Synthetic Preparation), PREP (Preparation) ((hetero)aromatic). 396092-82-3 belongs to class pyridine-derivatives, and the molecular formula is C7H9BrN2, Product Details of C7H9BrN2.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Jian-Wei; Xiong, Yuan; Wang, Feng; Zhang, Fu-Mao; Yang, Xiaodi; Lin, Guo-Qiang; Tian, Ping; Ge, Guangbo; Gao, Dingding published the artcile< Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CLpro inhibitors for treating COVID-19>, Related Products of 396092-82-3, the main research area is dihydrophenanthrene derivative SARS CoV2 coronavirus 3CLpro inhibitor COVID19; 9,10-Dihydrophenanthrenes; COVID-19; SARS-CoV-2 3CL(pro); Structure-activity relationships.

The epidemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now spread worldwide and efficacious therapeutics are urgently needed. 3-Chymotrypsin-like cysteine protease (3CLpro) is an indispensable protein in viral replication and represents an attractive drug target for fighting COVID-19. Herein, we report the discovery of 9,10-dihydrophenanthrene derivatives as non-peptidomimetic and non-covalent inhibitors of the SARS-CoV-2 3CLpro. The structure-activity relationships of 9,10-dihydrophenanthrenes as SARS-CoV-2 3CLpro inhibitors have carefully been investigated and discussed in this study. Among all tested 9,10-dihydrophenanthrene derivatives, C1 and C2 display the most potent SARS-CoV-2 3CLpro inhibition activity, with IC50 values of 1.55 ± 0.21μM and 1.81 ± 0.17μM, resp. Further enzyme kinetics assays show that these two compounds dose-dependently inhibit SARS-CoV-2 3CLprovia a mixed-inhibition manner. Mol. docking simulations reveal the binding modes of C1 in the dimer interface and substrate-binding pocket of the target. In addition, C1 shows outstanding metabolic stability in the gastrointestinal tract, human plasma, and human liver microsome, suggesting that this agent has the potential to be developed as an orally administered SARS-CoV-2 3CLpro inhibitor.

European Journal of Medicinal Chemistry published new progress about Anticoronaviral agents. 396092-82-3 belongs to class pyridine-derivatives, and the molecular formula is C7H9BrN2, Related Products of 396092-82-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Duong, Vincent K.; Horan, Alexandra M.; McGarrigle, Eoghan M. published the artcile< Synthesis of Pyridylsulfonium Salts and Their Application in the Formation of Functionalized Bipyridines>, Recommanded Product: 2-Bromo-N,N-dimethylpyridin-4-amine, the main research area is pyridylsulfide diphenyliodonium triflate copper selective arylation; pyridylsulfonium trifluoromethanesulfonate preparation; halopyridine organolithium pyridylsulfonium coupling; bipyridine preparation.

An S-selective arylation of pyridylsulfides with good functional group tolerance was developed. To demonstrate synthetic utility, the resulting pyridylsulfonium salts were used in a scalable transition-metal-free coupling protocol, yielding functionalized bipyridines with extensive functional group tolerance. This modular methodol. permits selective introduction of functional groups from com. available pyridyl halides, furnishing sym. and unsym. 2,2′- and 2,3′-bipyridines. Iterative application of the methodol. enabled the synthesis of a functionalized terpyridine with three different pyridine components.

Organic Letters published new progress about Arylation. 396092-82-3 belongs to class pyridine-derivatives, and the molecular formula is C7H9BrN2, Recommanded Product: 2-Bromo-N,N-dimethylpyridin-4-amine.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem