Adding a certain compound to certain chemical reactions, such as: 3978-81-2, 4-(tert-Butyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C9H13N, blongs to pyridine-derivatives compound. COA of Formula: C9H13N
At -20 C, N, N-dimethylethanolamine (8.91 g, 100 mmol, 2.0 eq.) Was added to 150 mL of n-hexane.S-BuLi (80 mL, 200 mmol, 4.0 eq.) Was added dropwise,After the dropwise addition is completed, the reaction is performed at -30 C for 30 minutes.4-tert-butylpyridine (6.76 g, 50 mmol, 1.0 eq) was added dropwise,After the dropwise addition was completed, the reaction was performed at -20 C for 1 hour.Cool to -70 C and add 1,1,2-trifluorotrichloroethane (18.74 g, 100 mmol, 2.0 eq) dropwise.After the dropwise addition was completed, the reaction was carried out at -20 C for 3 hours.The temperature was raised to 10 C and the reaction was allowed to proceed overnight.Pour into 100 L of ice water, extract with EA, wash with water,Column chromatography gave 5.09 g of a yellow solid, yield: 60.0%.
The synthetic route of 3978-81-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nanjing He Ju Pharmaceutical Co., Ltd.; Pan Guojun; Bai Zhao; (8 pag.)CN110041249; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem