Category: 39856-58-1

Ortgies, Stefan published the artcileSelenium-Catalyzed Oxidative C(sp²)-H Amination of Alkenes Exemplified in the Expedient Synthesis of (Aza-)Indoles, Category: pyridine-derivatives, the publication is Organic Letters (2015), 17(11), 2748-2751, database is CAplus and MEDLINE.

A new selenium-catalyzed protocol for the direct, intramol. amination of C(sp²)-H bonds using N-fluorobenzenesulfonimide as the terminal oxidant is reported. This method enables the facile formation of a broad range of diversely functionalized indoles and azaindoles derived from easily accessible ortho-vinyl anilines and vinylated aminopyridines, resp. The procedure exploits the pronounced carbophilicity of selenium electrophiles for the catalytic activation of alkenes and leads to the formation of C(sp²)-N bonds in high yields and with excellent functional group tolerance.

Organic Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Romito, Deborah published the artcileNon-covalent bridging of bithiophenes through chalcogen bonding grips, Category: pyridine-derivatives, the publication is New Journal of Chemistry (2020), 44(17), 6732-6738, database is CAplus.

In this work, chalcogen functionalized dithiophenes, equipped on both extremities with chalcogen-bonding recognition heterocycles, have been prepared following two synthetic pathways. The insertion of the chalcogenazolo[5,4-β]pyridine allows the control of the organization at the solid state. X-Ray diffraction anal. of the single crystals, showed that the Te-doped derivatives give the most persistant assemblies, with the mols. arranging at solid-state in wire-like polymeric structures through Te···N interactions. As expected, the introduction of the Se and Te atoms, dramatically decreases the emission properties, with the Te-bearing congeners being virtually non emissive.

New Journal of Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Empel, Anna published the artcileTowards Property Profiling: SYNTHESIS and SAR Probing of New Tetracyclic Diazaphenothiazine Analogues, Synthetic Route of 39856-58-1, the publication is International Journal of Molecular Sciences (2021), 22(23), 12826, database is CAplus and MEDLINE.

A series of new tertiary phenothiazine derivatives containing a quinoline and a pyridine fragment was synthesized by the reaction of 1-methyl-3-benzoylthio-4-butylthioquinolinium chloride with 3-aminopyridine derivatives bearing various substituents on the pyridine ring. The direction and mechanism of the cyclization reaction of intermediates with the structure of 1-methyl-4-(3-pyridyl)aminoquinolinium-3-thiolate was related to the substituents in the 2- and 4-pyridine position. The structures of the compounds were analyzed using 1H, 13C NMR (COSY, HSQC, HMBC) and X-ray anal., resp. Moreover, the antiproliferative activity against tumor cells (A549, T47D, SNB-19) and a normal cell line (NHDF) was tested. The antibacterial screening of all the compounds was conducted against the reference and quality control strain Staphylococcus aureus ATCC 29213, three clin. isolates of methicillin-resistant S. aureus (MRSA). In silico computation of the intermol. similarity was performed using principal component anal. (PCA) and hierarchical clustering anal. (HCA) on the pool of structure/property-related descriptors calculated for the novel tetracyclic diazaphenothiazine derivatives The distance-oriented property evaluation was correlated with the exptl. anticancer activities and empirical lipophilicity as well. The quant. shape-based comparison was conducted using the CoMSA method in order to indicate the potentially valid steric, electronic and lipophilic properties. Finally, the numerical sampling of similarity-related activity landscape (SALI) provided a subtle picture of the SAR trends.

International Journal of Molecular Sciences published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Synthetic Route of 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Siddle, Jamie S. published the artcileDivergent synthesis of arylated pyridin-2(1H)-one derivatives via metal-catalysed cross-coupling processes, Formula: C5H5BrN2, the publication is Tetrahedron (2010), 66(32), 6138-6149, database is CAplus.

1,5-Di(hetero)arylated-pyridin-2(1H)-one derivatives, e.g. I, have been readily obtained in good yields starting from 2-fluoro-5-pyridylboronic acid. The sequence comprises three steps: (i) palladium-catalyzed Suzuki-Miyaura reaction; (ii) base-catalyzed hydrolysis; (iii) copper-catalyzed C-N coupling. X-ray crystal structures are reported for selected pyridin-2(1H)-one derivatives These compounds are of interest as new scaffolds for drug discovery.

Tetrahedron published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C10H2F12NiO4, Formula: C5H5BrN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Empel, Anna published the artcileTowards Property Profiling: SYNTHESIS and SAR Probing of New Tetracyclic Diazaphenothiazine Analogues, Synthetic Route of 39856-58-1, the publication is International Journal of Molecular Sciences (2021), 22(23), 12826, database is CAplus and MEDLINE.

A series of new tertiary phenothiazine derivatives containing a quinoline and a pyridine fragment was synthesized by the reaction of 1-methyl-3-benzoylthio-4-butylthioquinolinium chloride with 3-aminopyridine derivatives bearing various substituents on the pyridine ring. The direction and mechanism of the cyclization reaction of intermediates with the structure of 1-methyl-4-(3-pyridyl)aminoquinolinium-3-thiolate was related to the substituents in the 2- and 4-pyridine position. The structures of the compounds were analyzed using 1H, 13C NMR (COSY, HSQC, HMBC) and X-ray anal., resp. Moreover, the antiproliferative activity against tumor cells (A549, T47D, SNB-19) and a normal cell line (NHDF) was tested. The antibacterial screening of all the compounds was conducted against the reference and quality control strain Staphylococcus aureus ATCC 29213, three clin. isolates of methicillin-resistant S. aureus (MRSA). In silico computation of the intermol. similarity was performed using principal component anal. (PCA) and hierarchical clustering anal. (HCA) on the pool of structure/property-related descriptors calculated for the novel tetracyclic diazaphenothiazine derivatives The distance-oriented property evaluation was correlated with the exptl. anticancer activities and empirical lipophilicity as well. The quant. shape-based comparison was conducted using the CoMSA method in order to indicate the potentially valid steric, electronic and lipophilic properties. Finally, the numerical sampling of similarity-related activity landscape (SALI) provided a subtle picture of the SAR trends.

International Journal of Molecular Sciences published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Synthetic Route of 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ferlin, Francesco published the artcileC(sp³)-H Arylation Promoted by a Heterogeneous Palladium-N-Heterocyclic Carbene Complex in Batch and Continuous Flow, Application In Synthesis of 39856-58-1, the publication is ChemSusChem (2022), 15(6), e202102736, database is CAplus and MEDLINE.

A heterogeneous reusable palladium(II)-bis(N-heterocyclic carbene) catalyst was prepared and shown to catalyze the intramol. C(sp³)-H activation/cyclization of N-alkyl-2-bromoanilines furnishing indolines. This new catalytic system was based on a bis-imidazolium ligand immobilized on a spaced cross-linked polystyrene support. The iodide ligands on the catalyst played a central role in the efficiency of the process occurring through a “release and catch” mechanism. The heterogeneous nature of the catalyst was further exploited in the design of a continuous-flow protocol that allowed a more efficient recovery and reuse of the catalyst, as well as a very fast and safe procedure.

ChemSusChem published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Application In Synthesis of 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Salameh, Nihad published the artcileHeterogeneous palladium-catalysed intramolecular C(sp³)-H α-arylation for the green synthesis of oxindoles, Recommanded Product: 2-Bromopyridin-3-amine, the publication is Molecular Catalysis (2022), 112211, database is CAplus.

The development of a waste-minimized protocol for the synthesis of oxindoles I [R = H, Me; R¹ = Me, Et, Bn; R² = H, Me, F; R³ = H, F, Me, CF₂; R⁴ = H, Me, Cl, CN, etc.; R⁵ = CH, N] using cyclopentyl Me ether (CPME) as a safe and green reaction medium and palladium on carbon (Pd/C) as a reusable catalyst was presented. This protocol is efficiently applied to a variety of substrates 2-R²-3-R³-4-R⁴-5-R⁵-6-X-C₆N(R¹)C(O)CH₃ [X = Br, Cl] affording products I with excellent yields, minimal metal contamination and min. waste production The catalyst was recovered and reused for four consecutive runs without any apparent loss of efficiency. Moreover, products I were isolated by simple precipitation from heptane with no need for chromatog. separations, and both CPME and heptane were recovered. Waste-minimization is reflected by the low E-factor calculated for the presented protocol.

Molecular Catalysis published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Recommanded Product: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Saifuddin, Mohammad published the artcileWater-accelerated cationic π-(7-endo) cyclization: application to indole-based Peri-annulated polyheterocycles, Quality Control of 39856-58-1, the publication is European Journal of Organic Chemistry (2010), 5108-5117, S5108/1-S5108/27, database is CAplus.

An efficient and versatile method for the synthesis of indole-based polycyclic indolo-benzazepine and its derivatives e. g., I, II through water-accelerated cationic π-cyclization is described. The strategy involves condensation of arylamine moieties linked to C-4 in indole/azaindole systems with arylaldehydes in water containing catalytic amount of Bronsted acids. The C-C bond formation in water is complete within 10-30 min, furnishing the title compounds in excellent yields and purities, whereas in organic solvents 10-12 h are required. Furthermore, aldehydes both with electron-donating and-withdrawing substituents facilitate the π-cyclization equally.

European Journal of Organic Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Quality Control of 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem