Category: 39856-58-1

In 2020,RSC Advances included an article by Recio, Javier; Filace, Fabiana; Gala, Elena; Perez-Redondo, Adrian; Alvarez-Builla, Julio; Burgos, Carolina. Reference of 2-Bromopyridin-3-amine. The article was titled 《Studies on the preparation of aminobipyridines and bipyridine sultams via an intramolecular free radical pathway》. The information in the text is summarized as follows:

A variety of aminated bipyridines and bipyridine sultams are prepared by intramol. radical [1,5]-ipso and [1,6]-ortho substitutions, using a sulfonamide as a linker to connect the pyridyl radical to the pyridine under attack. For the cases studied, different regiochemistries were observed depending on the initial position of the sulfonamide linker. In the experiment, the researchers used 2-Bromopyridin-3-amine(cas: 39856-58-1Reference of 2-Bromopyridin-3-amine)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Reference of 2-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,RSC Advances included an article by Qian, Yingjie; Jeong, Sang Yung; Baeck, Sung-Hyeon; Jin, Myung-Jong; Shim, Sang Eun. Recommanded Product: 39856-58-1. The article was titled 《A palladium complex confined in a thiadiazole-functionalized porous conjugated polymer for the Suzuki-Miyaura coupling reaction》. The information in the text is summarized as follows:

Porous organic polymers (POPs) with well-distributed and tunable functional groups acting as ligands for specific reactions are promising supports for confining useful novel metals such as Pd, Au, and Pd. Herein, a thiadiazole-containing POP has been successfully synthesized and used for immobilizing Pd species. Pd immobilized inside the micropores (2.3 nm) of the POP material is easily prepared owing to a large amount of the strong anchoring group, thiadiazole, which is intrinsically distributed in the as-prepared POP. The rigid thiadiazole-containing polymer can stabilize the central metal rather than poisoning it. The as-prepared catalyst shows excellent catalytic activity in Suzuki-Miyaura coupling reactions under mild reaction conditions and low catalyst loading. Importantly, the intrinsically distributed thiadiazole ligands can stabilize the Pd moiety, preventing aggregation and leaching, and afford excellent catalytic lifetimes. Consequently, the catalyst can be reused 10 times without a significant loss of its catalytic activity. In the experimental materials used by the author, we found 2-Bromopyridin-3-amine(cas: 39856-58-1Recommanded Product: 39856-58-1)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Recommanded Product: 39856-58-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 2-Bromopyridin-3-amineOn November 5, 2021 ,《Selective Thiocyanation and Aromatic Amination To Achieve Organized Annulation of Enaminone with Thiocyanate》 appeared in Organic Letters. The author of the article were Zhang, Jun; She, Mengyao; Liu, Lang; Feng, Xukai; Li, Yao; Liu, Hua; Zheng, Tingting; Leng, Xin; Liu, Ping; Zhang, Shengyong; Li, Jianli. The article conveys some information:

A tandem insertion of thiocyanate to enamine was performed for the regioselective synthesis of multisubstituted benzoimidazo[2,1-b]thiazoles. This method was shown to be effective in addressing the issue of isomerization encountered in common strategies. With a change made to the leading group on the aniline fragment of enamine, the reaction achieved different transformations, thus enabling multisubstituted benzo[4,5]imidazo[2,1-b]thiazoles and thiazoles in satisfactory yields. The experimental part of the paper was very detailed, including the reaction process of 2-Bromopyridin-3-amine(cas: 39856-58-1Quality Control of 2-Bromopyridin-3-amine)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Quality Control of 2-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liang, Ren-Xiao; Zhong, Chao; Liu, Zhi-Hong; Yang, Miao; Tang, Heng-Wei; Chen, Jian-Fei; Yang, Yun-Fang; Jia, Yi-Xia published an article on February 5 ,2021. The article was titled 《Enantioselective Arylation of Tetrasubstituted Enamines: Access to Enantioenriched Indolenine and 1H-Indole Derivatives》, and you may find the article in ACS Catalysis.Recommanded Product: 2-Bromopyridin-3-amine The information in the text is summarized as follows:

Palladium-catalyzed intramol. enantioselective β-arylation of tetrasubstituted endocyclic and exocyclic enamines was developed. A range of optically active medium-ring fused indolenines or 3,3′-spiroindolenines were achieved in enantiomeric ratios up to 98:2 with Cs2CO3 or K3PO4 as the base in the presence of chiral PHOX ligands. The use of Ag3PO4 as a base led to enantioenriched 1H-indoles in good enantiomeric ratios (up to 89:11) with (S)-DIFLUORPHOS as a chiral ligand, which proceeded via a possible domino enamine-isomerization/β-arylation sequence. The experimental part of the paper was very detailed, including the reaction process of 2-Bromopyridin-3-amine(cas: 39856-58-1Recommanded Product: 2-Bromopyridin-3-amine)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Recommanded Product: 2-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C5H5BrN2On October 4, 2019 ,《Silver-Mediated Trifluoromethoxylation of (Hetero)aryldiazonium Tetrafluoroborates》 was published in Organic Letters. The article was written by Yang, Yu-Ming; Yao, Jian-Fei; Yan, Wei; Luo, Zhuangzhu; Tang, Zhen-Yu. The article contains the following contents:

Here we report a silver-mediated trifluoromethoxylation of (hetero)aryldiazonium tetrafluoroborates by converting an aromatic amino group into an OCF3 group. This method, which can be considered to be a trifluoromethoxylation variation of the classic Sandmeyer-type reaction, uses readily available aryl and heteroaromatic amines as starting materials and AgOCF3 as trifluoromethoxylating reagents. The broad substrate scope and simple, mild reaction condition made this transformation a valuable method in constructing aryl-OCF3 bonds. In addition to this study using 2-Bromopyridin-3-amine, there are many other studies that have used 2-Bromopyridin-3-amine(cas: 39856-58-1Formula: C5H5BrN2) was used in this study.

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Formula: C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 2-Bromopyridin-3-amineOn March 22, 2022, Ferlin, Francesco; Anastasiou, Ioannis; Salameh, Nihad; Miyakoshi, Takeru; Baudoin, Olivier; Vaccaro, Luigi published an article in ChemSusChem. The article was 《C(sp3)-H Arylation Promoted by a Heterogeneous Palladium-N-Heterocyclic Carbene Complex in Batch and Continuous Flow》. The article mentions the following:

A heterogeneous reusable palladium(II)-bis(N-heterocyclic carbene) catalyst was prepared and shown to catalyze the intramol. C(sp3)-H activation/cyclization of N-alkyl-2-bromoanilines furnishing indolines. This new catalytic system was based on a bis-imidazolium ligand immobilized on a spaced cross-linked polystyrene support. The iodide ligands on the catalyst played a central role in the efficiency of the process occurring through a “”release and catch”” mechanism. The heterogeneous nature of the catalyst was further exploited in the design of a continuous-flow protocol that allowed a more efficient recovery and reuse of the catalyst, as well as a very fast and safe procedure. In addition to this study using 2-Bromopyridin-3-amine, there are many other studies that have used 2-Bromopyridin-3-amine(cas: 39856-58-1Application In Synthesis of 2-Bromopyridin-3-amine) was used in this study.

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Application In Synthesis of 2-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C5H5BrN2On June 7, 2021, Adamek, Rebecca N.; Suire, Caitlin N.; Stokes, Ryjul W.; Brizuela, Monica K.; Cohen, Seth M.; Leissring, Malcolm A. published an article in ChemMedChem. The article was 《Hydroxypyridinethione Inhibitors of Human Insulin-Degrading Enzyme》. The article mentions the following:

Insulin-degrading enzyme (IDE) is a human mononuclear Zn2+-dependent metalloenzyme that is widely regarded as the primary peptidase responsible for insulin degradation Despite its name, IDE is also critically involved in the hydrolysis of several other disparate peptide hormones, including glucagon, amylin, and the amyloid β-protein. As such, the study of IDE inhibition is highly relevant to deciphering the role of IDE in conditions such as type-2 diabetes mellitus and Alzheimer disease. There have been few reported IDE inhibitors, and of these, inhibitors that directly target the active-site Zn2+ ion have yet to be fully explored. In an effort to discover new, zinc-targeting inhibitors of IDE, a library of ∼350 metal-binding pharmacophores was screened against IDE, resulting in the identification of 1-hydroxypyridine-2-thione (1,2-HOPTO) as an effective Zn2+-binding scaffold. Screening a focused library of HOPTO compounds identified 3-sulfonamide derivatives of 1,2-HOPTO as inhibitors of IDE (Ki values of ∼50μM). Further structure-activity relationship studies yielded several thiophene-sulfonamide HOPTO derivatives with good, broad-spectrum activity against IDE that have the potential to be useful pharmacol. tools for future studies of IDE. After reading the article, we found that the author used 2-Bromopyridin-3-amine(cas: 39856-58-1Synthetic Route of C5H5BrN2)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Synthetic Route of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C5H5BrN2On November 20, 2020 ,《I(III)-Catalyzed Oxidative Cyclization-Migration Tandem Reactions of Unactivated Anilines》 appeared in Organic Letters. The author of the article were Deng, Tianning; Shi, Emily; Thomas, Elana; Driver, Tom G.. The article conveys some information:

An I(III)-catalyzed oxidative cyclization-migration tandem reaction using Selectfluor as the oxidant was developed that converts unactivated anilines into 3H-indoles is reported herein. The reaction requires as little as 1 mol % of the iodocatalyst and is mild, tolerating pyridine and thiophene functional groups, and the dependence of the diastereoselectivity of the process on the identity of the iodoarene or iodoalkane precatalyst suggests that the catalyst is present for the stereochem. determining C-N bond forming step. After reading the article, we found that the author used 2-Bromopyridin-3-amine(cas: 39856-58-1COA of Formula: C5H5BrN2)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.COA of Formula: C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Heterogeneous palladium-catalysed intramolecular C(sp3)-H α-arylation for the green synthesis of oxindoles》 was written by Salameh, Nihad; Anastasiou, Ioannis; Ferlin, Francesco; Minio, Francesco; Chen, Shaomin; Santoro, Stefano; Liu, Ping; Gu, Yanglong; Vaccaro, Luigi. Formula: C5H5BrN2 And the article was included in Molecular Catalysis on April 30 ,2022. The article conveys some information:

The development of a waste-minimized protocol for the synthesis of oxindoles I [R = H, Me; R1 = Me, Et, Bn; R2 = H, Me, F; R3 = H, F, Me, CF2; R4 = H, Me, Cl, CN, etc.; R5 = CH, N] using cyclopentyl Me ether (CPME) as a safe and green reaction medium and palladium on carbon (Pd/C) as a reusable catalyst was presented. This protocol is efficiently applied to a variety of substrates 2-R2-3-R3-4-R4-5-R5-6-X-C6N(R1)C(O)CH3 [X = Br, Cl] affording products I with excellent yields, minimal metal contamination and min. waste production The catalyst was recovered and reused for four consecutive runs without any apparent loss of efficiency. Moreover, products I were isolated by simple precipitation from heptane with no need for chromatog. separations, and both CPME and heptane were recovered. Waste-minimization is reflected by the low E-factor calculated for the presented protocol. In the experiment, the researchers used many compounds, for example, 2-Bromopyridin-3-amine(cas: 39856-58-1Formula: C5H5BrN2)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Formula: C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 39856-58-1On September 17, 2021 ,《Exploiting Iminoquinones as Electrophilic at Nitrogen “”N+”” Synthons for C-N Bond Construction》 was published in Organic Letters. The article was written by Mori-Quiroz, Luis M.; Comadoll, Chelsea G.; Super, Jonathan E.; Clift, Michael D.. The article contains the following contents:

New methods for C-N bond construction exploiting the N-centered electrophilic character of iminoquinones were reported. Iminoquinones, generated in situ via the condensation of o-vinylanilines with benzoquinones, underwent acid-catalyzed cyclization to afford N-arylindoles I [R = H, F; R1 = H, Me, Ph, etc.; R2 = H, Me; R3 = H, Cl, CO2Me, etc.; Ar = 3,5-di-(t-Bu)-4-OHC6H2, 3,5-di-Me-4-OHC6H2, 3,5-di-(t-Bu)-2-OHC6H2, 10-hydroxy-9-phenanthryl] in excellent yields. Under similar reaction conditions, homoallylic amines reacted analogously to afford N-arylpyrroles II [R4 = Ph, 3-MeOC6H4, 4-FC6H4, 2,6-di-FC6H3, 2,3-dihydrobenzofuran-5-yl; R5 = H, 4-MeC6H4; Ar = 3,5-di-(t-Bu)-4-OHC6H2]. Addnl., organometallic nucleophiles were shown to add to the nitrogen atom of N-alkyliminoquinones to provide amine products. Finally, iminoquinones were shown to be competent electrophiles for copper-catalyzed hydroamination. After reading the article, we found that the author used 2-Bromopyridin-3-amine(cas: 39856-58-1Product Details of 39856-58-1)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Product Details of 39856-58-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem