Category: 39856-58-1

In 2020,New Journal of Chemistry included an article by Romito, Deborah; Biot, Nicolas; Babudri, Francesco; Bonifazi, Davide. Application of 39856-58-1. The article was titled 《Non-covalent bridging of bithiophenes through chalcogen bonding grips》. The information in the text is summarized as follows:

In this work, chalcogen functionalized dithiophenes, equipped on both extremities with chalcogen-bonding recognition heterocycles, have been prepared following two synthetic pathways. The insertion of the chalcogenazolo[5,4-β]pyridine allows the control of the organization at the solid state. X-Ray diffraction anal. of the single crystals, showed that the Te-doped derivatives give the most persistant assemblies, with the mols. arranging at solid-state in wire-like polymeric structures through Te···N interactions. As expected, the introduction of the Se and Te atoms, dramatically decreases the emission properties, with the Te-bearing congeners being virtually non emissive. In the experiment, the researchers used 2-Bromopyridin-3-amine(cas: 39856-58-1Application of 39856-58-1)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Application of 39856-58-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis of unsymmetrical urea from aryl- or pyridyl carboxamides and aminopyridines using PhI(OAc)2via in situ formation of aryl- or pyridyl isocyanates》 was published in New Journal of Chemistry in 2021. These research results belong to Laha, Joydev K.; Singh, Neha; Hunjan, Mandeep Kaur. COA of Formula: C5H5BrN2 The article mentions the following:

A tandem synthesis of unsym. ureas (N-aryl-N’-pyridylurea and N,N’-bipyridylurea) from aryl- or pyridyl carboxamides and aminopyridines via Hofmann rearrangement has been reported. In particular, benzamides, picolinamide, nicotinamide, and isonicotinamide generate reactive intermediate isocyanates, in situ, in the presence of PhI(OAc)2, which upon further reaction with aminopyridines form urea derivatives As the formation of pyridylisocyanates from their corresponding carboxamides via Hofmann rearrangement remained unexplored previously, attempts have been made to trap the isocyanates. While the three pyridylisocyanates were trapped as their corresponding carbamates, 3-pyridylisocyanate was isolated and characterized. Unlike closely related previous methods reported for urea synthesis, the current method avoids direct use of isocyanates or eliminates the use of toxic phosgene for the in situ generation of isocyanates. In the experimental materials used by the author, we found 2-Bromopyridin-3-amine(cas: 39856-58-1COA of Formula: C5H5BrN2)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.COA of Formula: C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Venkateshwarlu, Rapolu; Nath Singh, Shambhu; Siddaiah, Vidavalur; Ramamohan, Hindupur; Dandela, Rambabu; Pal, Manojit published their research in Tetrahedron Letters on December 26 ,2019. The article was titled 《Ultrasound assisted one-pot synthesis of 1,2-diaryl azaindoles via Pd/C-Cu catalysis: Identification of potential cytotoxic agents》.Related Products of 39856-58-1 The article contains the following contents:

Ultrasound assisted one-pot and direct access to 1,2-diaryl substituted azaindole derivatives I [W = CH, N; X = CH, N; Y = CH, N; Z = CH, N; Ar1 = Ph, 4-ClC6H4, 4-MeC6H4; Ar2 = 4-CNC6H4, 4-MeOC6H4, 4-Me(SO2)C6H4, etc.] was achieved via the sequential N-arylation followed by coupling-cyclization under Pd/C-Cu catalysis. The methodol. involved initial C-N bond forming reaction (step 1) between an appropriate o-bromo substituted amino pyridine and iodoarene followed by C-C and C-N bond formation (step 2) between the resulting N-aryl substituted intermediate and a terminal alkyne in the same pot. A variety of azaindoles were prepared by using this method. These compounds were assessed for their cytotoxic properties against two different metastatic breast cancer cell lines e.g. MDA-MB-231 and MCF-7. Compounds I [W = Y = Z = CH, X = N, Ar1 = 4-MeC6H4, Ar2 = 4-MeOC6H4], I [W = Y = Z = CH, X = N, Ar1 = Ph, Ar2 = 4-MeOC6H4] and I [W = Y = Z = CH, X = N, Ar1 = 4-ClC6H4, Ar2 = 3,5-di-MeOC6H3] showed promising growth inhibition of these cell lines and SIRT1 inhibition in vitro. The results came from multiple reactions, including the reaction of 2-Bromopyridin-3-amine(cas: 39856-58-1Related Products of 39856-58-1)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Related Products of 39856-58-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of C5H5BrN2On March 4, 2020, Biot, Nicolas; Bonifazi, Davide published an article in Chemistry – A European Journal. The article was 《Concurring Chalcogen- and Halogen-Bonding Interactions in Supramolecular Polymers for Crystal Engineering Applications》. The article mentions the following:

The engineering of crystalline mol. solids through the simultaneous combination of distinctive non-covalent interactions is an important field of research, as it could allow chemist to prepare materials depicting multi-responsive properties. It is in this context that, pushed by a will to expand the chem. space of chalcogen-bonding interactions, a concept is put forward for which chalcogen- and halogen-bonding interactions can be used simultaneously to engineer multicomponent co-crystals. Through the rational design of crystallizable mols., chalcogenazolo pyridine scaffold (CGP) modules were prepared that, bearing either a halogen-bond acceptor or donor at the 2-position, can interact with suitable complementary mol. modules undergoing formation of supramol. polymers at the solid state. The recognition reliability of the CGP moiety to form chalcogen-bonded dimers allows the formation of heteromol. supramol. polymers through halogen-bonding interactions, as confirmed by single-crystal X-ray diffraction anal. The results came from multiple reactions, including the reaction of 2-Bromopyridin-3-amine(cas: 39856-58-1Synthetic Route of C5H5BrN2)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Synthetic Route of C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2019,Chemistry – A European Journal included an article by Kader, Thomas; Stoeger, Berthold; Froehlich, Johannes; Kautny, Paul. Related Products of 39856-58-1. The article was titled 《Azaindolo[3,2,1-jk]carbazoles: New Building Blocks for Functional Organic Materials》. The information in the text is summarized as follows:

The preparation and characterization of 12 azaindolo[3,2,1-jk]carbazoles, e.g., I was presented. Ring-closing C-H activation allowed for the convenient preparation of six singly and six doubly nitrogen-substituted indolo[3,2,1-jk]carbazole derivatives in which ten of the materials had not been described in the literature before. The detailed photophys. and electrochem. characterization of the developed materials revealed a significant impact of the incorporation of pyridine-like nitrogen into the fully planar indolo[3,2,1-jk]carbazole backbone. Furthermore, the nitrogen position decisively impacted intermol. hydrogen bonding and thus the solid-state alignment. Ultimately, the versatility of the azaindolo[3,2,1-jk]carbazoles scaffold makes this class of materials an attractive new building block for the design of functional organic materials. In the part of experimental materials, we found many familiar compounds, such as 2-Bromopyridin-3-amine(cas: 39856-58-1Related Products of 39856-58-1)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Related Products of 39856-58-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Discovery of 5-{2-[5-Chloro-2-(5-ethoxyquinoline-8-sulfonamido)phenyl]ethynyl}-4-methoxypyridine-2-carboxylic Acid, a Highly Selective in Vivo Useable Chemical Probe to Dissect MCT4 Biology》 was written by Heinrich, Timo; Sala-Hojman, Ada; Ferretti, Roberta; Petersson, Carl; Minguzzi, Stefano; Gondela, Andrzej; Ramaswamy, Shivapriya; Bartosik, Anna; Czauderna, Frank; Crowley, Lindsey; Wahra, Pamela; Schilke, Heike; Boepple, Pia; Dudek, Lukasz; Les, Marcin; Niedziejko, Paulina; Olech, Kamila; Pawlik, Henryk; Wloszczak, Lukasz; Zuchowicz, Karol; Suarez Alvarez, Jose Ramon; Martyka, Justyna; Sitek, Ewa; Mikulski, Maciej; Szczesniak, Joanna; Jaeckel, Sven; Krier, Mireille; Krol, Marcin; Wegener, Ansgar; Galezowski, Michal; Nowak, Mateusz; Becker, Frank; Herhaus, Christian. Recommanded Product: 39856-58-1 And the article was included in Journal of Medicinal Chemistry on August 26 ,2021. The article conveys some information:

Due to increased lactate production during glucose metabolism, tumor cells heavily rely on efficient lactate transport to avoid intracellular lactate accumulation and acidification. Monocarboxylate transporter 4 (MCT4/SLC16A3) is a lactate transporter that plays a central role in tumor pH modulation. The discovery and optimization of a novel class of MCT4 inhibitors (hit 9a), identified by a cellular screening in MDA-MB-231, is described. Direct target interaction of the optimized compound 18n with the cytosolic domain of MCT4 was shown after solubilization of the GFP-tagged transporter by fluorescence cross-correlation spectroscopy and microscopic studies. In vitro treatment with 18n resulted in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. Moreover, pharmacokinetic properties of 18n allowed assessment of lactate modulation and antitumor activity in a mouse tumor model. Thus, 18n represents a valuable tool for investigating selective MCT4 inhibition and its effect on tumor biol. After reading the article, we found that the author used 2-Bromopyridin-3-amine(cas: 39856-58-1Recommanded Product: 39856-58-1)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Recommanded Product: 39856-58-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Cesium Fluoride and Copper-Catalyzed One-Pot Synthesis of Benzoxazoles via a Site-Selective Amide C-N Bond Cleavage》 was published in Advanced Synthesis & Catalysis in 2019. These research results belong to Luo, Zhongfeng; Wu, Hongxiang; Li, Yue; Chen, Yuwen; Nie, Jingyi; Lu, Siqi; Zhu, Yulin; Zeng, Zhuo. Safety of 2-Bromopyridin-3-amine The article mentions the following:

We report herein a two-step one-pot strategy for the synthesis of benzoxazoles from amides by using cesium fluoride/copper as catalysts. This approach involves the in situ generation of acyl fluorides from the corresponding amides, and the acyl fluorides undergo transamidation and cyclization to give benzoxazoles in good yields. In this work, the amide C-N bonds are activated by CsF to form the acyl fluoride intermediates, which further react with o-bromoanilines to efficiently yield benzoxazoles. Notably, this methodol. demonstrates a broad substrate scope, as primary/secondary benzamides are well tolerated, and this process might facilitate the development of one-pot transformations of amides. In the experimental materials used by the author, we found 2-Bromopyridin-3-amine(cas: 39856-58-1Safety of 2-Bromopyridin-3-amine)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Safety of 2-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C5H5BrN2On May 19, 2022 ,《Base-Mediated Remote Deuteration of N-Heteroarenes – Broad Scope and Mechanism》 appeared in European Journal of Organic Chemistry. The author of the article were Kopf, Sara; Liu, Jiali; Franke, Robert; Jiao, Haijun; Neumann, Helfried; Beller, Matthias. The article conveys some information:

Using KOtBu as base and DMSO-d6 as deuterium source, a general and applicable method was presented for the selective deuteration of a set of nitrogen-containing heterocycles (pyridines, azines and bioactive mols.). Exptl. and DFT mechanistic studies indicated that this reaction proceeded via deprotonation of the substrates by the dimsyl anion. The relative thermodn. stability of the heterocycle anions determines the distribution and degree of deuteration. In the experiment, the researchers used 2-Bromopyridin-3-amine(cas: 39856-58-1Formula: C5H5BrN2)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Formula: C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 2-Bromopyridin-3-amineOn May 3, 2020 ,《Synthesis of [3.4]-Spirooxindoles through Cascade Carbopalladation of Skipped Dienes》 appeared in Advanced Synthesis & Catalysis. The author of the article were Azizollahi, Hamid; Perez-Gomez, Marta; Mehta, Vaibhav P.; Garcia-Lopez, Jose-Antonio. The article conveys some information:

A synthetic route to [3.4]-spirooxindoles based on cascade carbopalladation reactions of 1,4-dienes was described. While carbopalladation of alkenes have been used to access mainly [4.4]- or [4.5]-spirocycles, 4-exo-trig carbopalladation was not been yet applied to the synthesis of relevant [3.4]-spirooxindole scaffolds bearing a cyclobutyl ring. In addition, the cascade reaction generates an exocyclic double bond that can serve as a platform to further diversify the substitution pattern of the spirooxindole nuclei. The experimental part of the paper was very detailed, including the reaction process of 2-Bromopyridin-3-amine(cas: 39856-58-1Name: 2-Bromopyridin-3-amine)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Name: 2-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhu, Heping; Ying, Shilong; Zhou, Bingluo; Liang, Xiao; He, Quan; Song, Ping; Hu, Xinyang; Shi, Keqiang; Xiong, Mingteng; Jin, Hongchuan; Pan, Yuanjiang published an article on February 5 ,2021. The article was titled 《Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities》, and you may find the article in European Journal of Medicinal Chemistry.Application In Synthesis of 2-Bromopyridin-3-amine The information in the text is summarized as follows:

In this study, a series of novel 2-aryl-3-sulfonamido-pyridines had been designed, synthesized, and evaluated for their antiproliferative activities in vitro and in vivo. Among them, compound I exhibited the most potent activity with IC50 values ranging from 0.170 to 1.193μM in a panel of cancer cell lines. Mechanistic studies indicated that compound I bound to the colchicine site of β-tubulin, resulting in colony formation inhibition, G2/M phase cell cycle arrest, cell apoptosis as well as increased the generation of ROS in both RKO and SW620 cells. In addition, compound I showed potent anti-vascular activity in vitro. Furthermore, compound I also exhibited outstanding antitumor activity in SW620 xenograft tumor models without observable toxic effects, which was more potent than that of ABT-751. In conclusion, these findings suggest that compound I may be a promising microtubule destabilizing agent and deserves for further development in cancer therapy. The experimental process involved the reaction of 2-Bromopyridin-3-amine(cas: 39856-58-1Application In Synthesis of 2-Bromopyridin-3-amine)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Application In Synthesis of 2-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem