Category: 39856-58-1

Plamthottam, Sheba’s team published research in JBIC, Journal of Biological Inorganic Chemistry in 2019 | CAS: 39856-58-1

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.HPLC of Formula: 39856-58-1

《Activity and electrochemical properties: iron complexes of the anticancer drug triapine and its analogs》 was written by Plamthottam, Sheba; Sun, Daniel; Van Valkenburgh, Juno; Valenzuela, Jeffrey; Ruehle, Bastian; Steele, Dalton; Poddar, Soumya; Marshalik, Maxim; Hernandez, Selena; Radu, Caius Gabriel; Zink, Jeffrey I.. HPLC of Formula: 39856-58-1 And the article was included in JBIC, Journal of Biological Inorganic Chemistry on August 31 ,2019. The article conveys some information:

Abstract: Triapine (3-AP), is an iron-binding ligand and anticancer drug that is an inhibitor of human ribonucleotide reductase (RNR). Inhibition of RNR by 3-AP results in the depletion of dNTP precursors of DNA, thereby selectively starving fast-replicating cancer cells of nucleotides for survival. The redox-active form of 3-AP directly responsible for inhibition of RNR is the Fe(II)(3-AP)2 complex. In this work, we synthesize 12 analogs of 3-AP, test their inhibition of RNR in vitro, and study the electronic properties of their iron complexes. The reduction and oxidation events of 3-AP iron complexes that are crucial for the inhibition of RNR are modeled with solution studies. We monitor the pH necessary to induce reduction in iron complexes of 3-AP analogs in a reducing environment, as well as the kinetics of oxidation in an oxidizing environment. The oxidation state of the complex is monitored using UV-Vis spectroscopy. Isoquinoline analogs of 3-AP favor the maintenance of the biol. active reduced complex and possess oxidation kinetics that allow redox cycling, consistent with their effective inhibition of RNR seen in our in vitro experiments In contrast, methylation on the thiosemicarbazone secondary amine moiety of 3-AP produces analogs that form iron complexes with much higher redox potentials, that do not redox cycle, and are inactive against RNR in vitro. Graphic abstract: The catalytic subunit of human Ribonucleotide Reductase (RNR), contains a tyrosyl radical in the enzyme active site. Fe(II) complexes of 3-AP and its analogs can quench the radical and, subsequently, inactivate RNR. The potency of RNR inhibitors is highly dependent on the redox properties of the iron complexes, which can be tuned by ligand modifications. Complexes are found to be active within a narrow redox window imposed by the cellular environment.[Figure not available: see fulltext.]. In the experimental materials used by the author, we found 2-Bromopyridin-3-amine(cas: 39856-58-1HPLC of Formula: 39856-58-1)

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.HPLC of Formula: 39856-58-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Qian, Yingjie’s team published research in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2019 | CAS: 39856-58-1

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).HPLC of Formula: 39856-58-1

Qian, Yingjie; So, Jaeil; Lee, Myeong Yeon; Hwang, Sosan; Jin, Myung-Jong; Shim, Sang Eun published an article in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands). The title of the article was 《Synthesis of novel and room temperature-operable palladium complexes on graphene oxide: An efficient recyclable catalyst for Suzuki-Miyaura coupling reactions》.HPLC of Formula: 39856-58-1 The author mentioned the following in the article:

Novel palladium complexes composed of palladium and a conjugated ligand (imine-aldehyde) were immobilized on graphene oxide. The developed catalyst was characterized by XPS, and TEM. The novel catalyst was proven to be highly efficient for the Suzuki-Miyaura coupling reaction of aryl halides (Br, Cl) with arylboronic acids under mild conditions with a low amount of catalyst (0.1 mol%). In particular, excellent yields could be also obtained at room temperature within 1 h for monosubstituted aryl bromide coupling. Furthermore, the novel catalyst could be reused at least ten times without significant loss of its catalytic activities.2-Bromopyridin-3-amine(cas: 39856-58-1HPLC of Formula: 39856-58-1) was used in this study.

2-Bromopyridin-3-amine(cas: 39856-58-1) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).HPLC of Formula: 39856-58-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sources of common compounds: 2-Bromopyridin-3-amine

With the rapid development of chemical substances, we look forward to future research findings about 39856-58-1.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 39856-58-1, name is 2-Bromopyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-Bromopyridin-3-amine

1.22 ml 2-oxo-propionic acid, 0.26 g palladium acetate and 3.20 ml triethylamine were added to a solution of 1.00 g 2-bromo-pyridin-3-yl amine and 1.21 g triphenyl-phosphine in 10 ml N,N-dimethylformamide. The reaction mixture was stirred for 4 hours at 100C. After removal of the solvent under reduced pressure, the residue was purified by column chromatography on silica gel with dichloromethane/ methanol as eluent. Yield: 260 mg MS(ES+): m/e=163. 1H-NMR (400 MHz, DMSO/TMS): delta = 13.30 (s, 1H); 12.00 (s, 1H); 8.45 (d, 1H); 7.82 (d, 1H); 7.25 (dd, 1H); 7.14 (s, 1H)

With the rapid development of chemical substances, we look forward to future research findings about 39856-58-1.

Reference:
Patent; Aventis Pharma Deutschland GmbH; EP1479680; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sources of common compounds: 2-Bromopyridin-3-amine

With the rapid development of chemical substances, we look forward to future research findings about 39856-58-1.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 39856-58-1, name is 2-Bromopyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-Bromopyridin-3-amine

1.22 ml 2-oxo-propionic acid, 0.26 g palladium acetate and 3.20 ml triethylamine were added to a solution of 1.00 g 2-bromo-pyridin-3-yl amine and 1.21 g triphenyl-phosphine in 10 ml N,N-dimethylformamide. The reaction mixture was stirred for 4 hours at 100C. After removal of the solvent under reduced pressure, the residue was purified by column chromatography on silica gel with dichloromethane/ methanol as eluent. Yield: 260 mg MS(ES+): m/e=163. 1H-NMR (400 MHz, DMSO/TMS): delta = 13.30 (s, 1H); 12.00 (s, 1H); 8.45 (d, 1H); 7.82 (d, 1H); 7.25 (dd, 1H); 7.14 (s, 1H)

With the rapid development of chemical substances, we look forward to future research findings about 39856-58-1.

Reference:
Patent; Aventis Pharma Deutschland GmbH; EP1479680; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem