Category: 39856-58-1

Zhu, Tong-Hao published the artcileCo(acac)₂/O₂-Mediated Oxidative Isocyanide Insertion with 2-Aryl Anilines: Efficient Synthesis of 6-Amino Phenanthridine Derivatives, Recommanded Product: 2-Bromopyridin-3-amine, the publication is Organic Letters (2014), 16(4), 1260-1263, database is CAplus and MEDLINE.

A novel and efficient protocol for the creation of 6-amino phenanthridine derivatives, e.g., I, by Co(acac)₂-catalyzed isocyanide insertion with 2-aryl anilines under an O₂ atmosphere via homolytic aromatic substitution (HAS) type C-H functionalization has been developed. This reaction not only proceeds smoothly utilizing O₂ as the oxidant but also provides a new approach to construct phenanthridine derivatives utilizing readily available 2-aryl anilines with isocyanides instead of 2-isocyanobiaryls with different radical precursors.

Organic Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C7H12ClNO, Recommanded Product: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kandasamy, M. published the artcileMolecular structure and vibrational spectra of 3-and 4-amino-2-bromopyridine by density functional methods, Safety of 2-Bromopyridin-3-amine, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2012), 206-216, database is CAplus and MEDLINE.

Exptl. and theor. study on the mol. structure and the vibrational spectra of 3-amino-2-bromopyridine (Compound I) and 4-amino-2-bromopyridine (Compound II) are presented. The vibrational frequencies of these compounds were obtained theor. by DFT/B3LYP employing the 6-311G(2df,2p) basis set for optimized geometries and were compared with FTIR solid phase spectra (FTIR) at 400-4000 cm^-1, FT-Raman spectra at 100-4000 cm^-1 and with solution phase spectra at 400-4000 cm^-1. Complete vibrational assignment, anal. and correlation of the fundamental modes for these compounds were carried based on the potential energy distribution (PED). The vibrational harmonic frequencies were scaled using scale factors, yielding a good agreement between the exptl. recorded and the theor. calculated values. Finally the calculated HOMO and LUMO energies are localized on the entire ring and substituents.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Safety of 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bumagin, N. A. published the artcileAn effective activation of palladium phosphine complexes in aqueous phase reactions of heteroaromatic boronic acids with aryl halides, Formula: C5H5BrN2, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2014), 50(1), 19-25, database is CAplus.

A simple and effective method was developed for the activation of palladium-phosphine complexes in the Suzuki reaction (TON up to 9800, TOF up to 58800 h^-1) by selecting an aqueous reaction medium instead of organic solvents. This method was elaborated for a high yield synthesis of heteroaromatic biaryls with furyl and thienyl groups.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Formula: C5H5BrN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bowers, Simeon published the artcileDesign and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration, Product Details of C5H5BrN2, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(18), 5521-5527, database is CAplus and MEDLINE.

The SAR of a series of brain penetrant, trisubstituted thiophene based JNK inhibitors with improved pharmacokinetic properties is described. These compounds were designed based on information derived from metabolite identification studies which led to compounds such as 42 (I) with lower clearance, greater brain exposure and longer half life compared to earlier analogs.

Bioorganic & Medicinal Chemistry Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Product Details of C5H5BrN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hanan, Emily J. published the artcileDiscovery of Potent and Selective Pyrazolopyrimidine Janus Kinase 2 Inhibitors, Recommanded Product: 2-Bromopyridin-3-amine, the publication is Journal of Medicinal Chemistry (2012), 55(22), 10090-10107, database is CAplus and MEDLINE.

The discovery of somatic Jak2 mutations in patients with chronic myeloproliferative neoplasms has led to significant interest in discovering selective Jak2 inhibitors for use in treating these disorders. A high-throughput screening effort identified the pyrazolo[1,5-a]pyrimidine scaffold as a potent inhibitor of Jak2. Optimization of lead compounds in this chem. series for activity against Jak2, selectivity against other Jak family kinases, and good in vivo pharmacokinetic properties led to the discovery of (I). In a SET2 xenograft model that is dependent on Jak2 for growth, I demonstrated a time-dependent knock-down of pSTAT5, a downstream target of Jak2.

Journal of Medicinal Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Recommanded Product: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Estevez, Veronica published the artcileSynthesis of Pyridopyrimidines by Palladium-Catalyzed Isocyanide Insertion, Recommanded Product: 2-Bromopyridin-3-amine, the publication is ACS Catalysis (2014), 4(1), 40-43, database is CAplus.

A new synthetic approach to 4-aminopyrido-[2,3-d]-pyrimidines and 4-aminopyrido-[3,2-d]-pyrimidines based on palladium-catalyzed reaction of isocyanides with readily available N-(bromopyridyl)amidines is reported. The target heterocycles, e.g., I, were obtained in generally good to excellent yield. For the two regioisomeric pyrimidopyrimidines, the authors compared our approach involving oxidative addition with the analogous C-H activation protocol because both methods have been reported for the synthesis of 4-aminoquinazolines. It was found that the C-H activation protocol does not allow one to obtain the target pyridopyrimidines, but the imidoylative cross-coupling protocol provided a new entry to the synthesis of these medicinally important scaffolds.

ACS Catalysis published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Recommanded Product: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yamada, Yasuyuki published the artcileMetal-Induced Structural Switching of a Folded Quinone-Sandwiched Porphyrin, Category: pyridine-derivatives, the publication is Journal of Inorganic and Organometallic Polymers and Materials (2013), 23(1), 180-185, database is CAplus.

The authors report the synthesis of a novel quinone-sandwiched porphyrin in which two benzoquinones are connected oppositely at the meso positions of a porphyrin through rigid 3-amido 2,2′-bipyridine linkers. ¹H-NMR and single crystal x-ray analyses revealed that the quinone-sandwiched porphyrin has a folded structure in which the porphyrin unit was inserted into the two quinone moieties via π-stacking. Insertion of a Zn(II) ion into the porphyrin center induced a drastic conformational change which is resulted in coordination of the oxygen atoms of both benzoquinone moieties to the Zn-porphyrin to afford a 6-coordinated structure.

Journal of Inorganic and Organometallic Polymers and Materials published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C7H13BrSi, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Plamthottam, Sheba published the artcileActivity and electrochemical properties: iron complexes of the anticancer drug triapine and its analogs, Name: 2-Bromopyridin-3-amine, the publication is JBIC, Journal of Biological Inorganic Chemistry (2019), 24(5), 621-632, database is CAplus and MEDLINE.

Abstract: Triapine (3-AP), is an iron-binding ligand and anticancer drug that is an inhibitor of human ribonucleotide reductase (RNR). Inhibition of RNR by 3-AP results in the depletion of dNTP precursors of DNA, thereby selectively starving fast-replicating cancer cells of nucleotides for survival. The redox-active form of 3-AP directly responsible for inhibition of RNR is the Fe(II)(3-AP)₂ complex. In this work, we synthesize 12 analogs of 3-AP, test their inhibition of RNR in vitro, and study the electronic properties of their iron complexes. The reduction and oxidation events of 3-AP iron complexes that are crucial for the inhibition of RNR are modeled with solution studies. We monitor the pH necessary to induce reduction in iron complexes of 3-AP analogs in a reducing environment, as well as the kinetics of oxidation in an oxidizing environment. The oxidation state of the complex is monitored using UV-Vis spectroscopy. Isoquinoline analogs of 3-AP favor the maintenance of the biol. active reduced complex and possess oxidation kinetics that allow redox cycling, consistent with their effective inhibition of RNR seen in our in vitro experiments In contrast, methylation on the thiosemicarbazone secondary amine moiety of 3-AP produces analogs that form iron complexes with much higher redox potentials, that do not redox cycle, and are inactive against RNR in vitro. Graphic abstract: The catalytic subunit of human Ribonucleotide Reductase (RNR), contains a tyrosyl radical in the enzyme active site. Fe(II) complexes of 3-AP and its analogs can quench the radical and, subsequently, inactivate RNR. The potency of RNR inhibitors is highly dependent on the redox properties of the iron complexes, which can be tuned by ligand modifications. Complexes are found to be active within a narrow redox window imposed by the cellular environment.[Figure not available: see fulltext.].

JBIC, Journal of Biological Inorganic Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Name: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kader, Thomas published the artcileAzaindolo[3,2,1-jk]carbazoles: New Building Blocks for Functional Organic Materials, Application of 2-Bromopyridin-3-amine, the publication is Chemistry – A European Journal (2019), 25(17), 4412-4425, database is CAplus and MEDLINE.

The preparation and characterization of 12 azaindolo[3,2,1-jk]carbazoles, e.g., I was presented. Ring-closing C-H activation allowed for the convenient preparation of six singly and six doubly nitrogen-substituted indolo[3,2,1-jk]carbazole derivatives in which ten of the materials had not been described in the literature before. The detailed photophys. and electrochem. characterization of the developed materials revealed a significant impact of the incorporation of pyridine-like nitrogen into the fully planar indolo[3,2,1-jk]carbazole backbone. Furthermore, the nitrogen position decisively impacted intermol. hydrogen bonding and thus the solid-state alignment. Ultimately, the versatility of the azaindolo[3,2,1-jk]carbazoles scaffold makes this class of materials an attractive new building block for the design of functional organic materials.

Chemistry – A European Journal published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Application of 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Adamek, Rebecca N. published the artcileHydroxypyridinethione Inhibitors of Human Insulin-Degrading Enzyme, Recommanded Product: 2-Bromopyridin-3-amine, the publication is ChemMedChem (2021), 16(11), 1775-1787, database is CAplus and MEDLINE.

Insulin-degrading enzyme (IDE) is a human mononuclear Zn2+-dependent metalloenzyme that is widely regarded as the primary peptidase responsible for insulin degradation Despite its name, IDE is also critically involved in the hydrolysis of several other disparate peptide hormones, including glucagon, amylin, and the amyloid β-protein. As such, the study of IDE inhibition is highly relevant to deciphering the role of IDE in conditions such as type-2 diabetes mellitus and Alzheimer disease. There have been few reported IDE inhibitors, and of these, inhibitors that directly target the active-site Zn2+ ion have yet to be fully explored. In an effort to discover new, zinc-targeting inhibitors of IDE, a library of âˆ?50 metal-binding pharmacophores was screened against IDE, resulting in the identification of 1-hydroxypyridine-2-thione (1,2-HOPTO) as an effective Zn2+-binding scaffold. Screening a focused library of HOPTO compounds identified 3-sulfonamide derivatives of 1,2-HOPTO as inhibitors of IDE (Ki values of âˆ?0μM). Further structure-activity relationship studies yielded several thiophene-sulfonamide HOPTO derivatives with good, broad-spectrum activity against IDE that have the potential to be useful pharmacol. tools for future studies of IDE.

ChemMedChem published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Recommanded Product: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem