Reference of 39890-98-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 39890-98-7, name is 2,6-Dichloro-4-(trifluoromethyl)pyridine, molecular formula is C6H2Cl2F3N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 2,6-dichloro-4-(trifluoromethyl)pyridine (2.0 g) in dry methanol (40 ml) was added a solution of sodium hydroxide (1.85 g) in dry methanol (7ml) and the reaction mixture stirred at 50C under nitrogen for two hours then allowed to cool. The reaction mixture was extracted with pentane (2 x 100 ml), and the extract combined and evaporated to afford the title compound (1.69 g) as a colourless oil. LCMS: Rt 1.75 min, m/z 212/214 [M+H]+. 1H-NMR (400 MHz, CDC13) delta (ppm): 4.00 (s, 3 H) 6.89 (s, 1 H) 7.12 (s, 1 H)
According to the analysis of related databases, 39890-98-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; HALL, Adrian; FARTHING, Christopher Neil; EATHERTON, Andrew John; WO2014/13076; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem