Category: 39891-05-9

Safety of (6-Fluoropyridin-3-yl)methanol. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: (6-Fluoropyridin-3-yl)methanol, is researched, Molecular C6H6FNO, CAS is 39891-05-9, about Efficient Pyridinylmethyl Functionalization: Synthesis of 10,10-Bis[(2-fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone (DMP 543), an Acetylcholine Release Enhancing Agent. Author is Pesti, Jaan A.; Huhn, George F.; Yin, Jianguo; Xing, Yide; Fortunak, Joseph M.; Earl, Richard A..

2-Fluoro-4-methylpyridine is efficiently functionalized by chlorination, hydrolysis and methanesulfonylation into the novel alkylating agent 2-Fluoro-4-methanesulfonylmethylpyridine. This mesylate is used for the bisalkylation of anthrone under carefully defined conditions to prepare the title compound, a cognition enhancer drug candidate. This process proceeds in up to 37% overall yield and is adaptable for large scale synthesis. The chlorination of other methylpyridines was also investigated.

《Efficient Pyridinylmethyl Functionalization: Synthesis of 10,10-Bis[(2-fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone (DMP 543), an Acetylcholine Release Enhancing Agent》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound((6-Fluoropyridin-3-yl)methanol)Safety of (6-Fluoropyridin-3-yl)methanol.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Dimethylpyridin-4-ylamine-catalysed alcoholysis of 2-amino-N,N,N-trimethyl-9H-purine-6-ylammonium chloride: An effective route to O6-substituted guanine derivatives from alcohols with poor nucleophilicity, published in 2002-03-31, which mentions a compound: 39891-05-9, Name is (6-Fluoropyridin-3-yl)methanol, Molecular C6H6FNO, Formula: C6H6FNO.

Dimethylpyridin-4-ylamine (DMAP)-catalyzed reactions of 2-amino-N,N,N-trimethyl-9H-purine-6-ylammonium chloride with fluoropyridine methoxides and various other alkoxides in DMSO at 60 °C gave the corresponding coupling products in moderate to good yields between 20-87%. Under these reaction conditions, fluorinated O6-substituted Guanine derivatives have been synthesized which could not be obtained via known analogous literature procedures. The resp. yields of known O6-substituted guanine derivatives could be significantly improved by using this method. The efficient use of DMAP as an excellent nucleophilic catalyst in the syntheses of O6-substituted Guanine derivatives has thus been demonstrated.

There are many compounds similar to this compound(39891-05-9)Formula: C6H6FNO. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (6-Fluoropyridin-3-yl)methanol, is researched, Molecular C6H6FNO, CAS is 39891-05-9, about Identification and Development of a New Positron Emission Tomography Ligand 4-(2-Fluoro-4-[11C]methoxyphenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide for Imaging Metabotropic Glutamate Receptor Subtype 2 (mGlu2).Safety of (6-Fluoropyridin-3-yl)methanol.

Metabotropic glutamate receptor 2 (mGlu2) is a known target for treating several central nervous system (CNS) disorders. To develop a viable positron emission tomog. (PET) ligand for mGlu2, we identified new candidates 5a-i that are potent neg. allosteric modulators (NAMs) of mGlu2. Among these candidates, 4-(2-fluoro-4-methoxyphenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide (5i, also named as [11C]MG2-1812) exhibited high potency, high subtype selectivity, and favorable lipophilicity. Compound 5i was labeled with positron-emitting carbon-11 (11C) to obtain [11C]5i in high radiochem. yield and high molar activity by O-[11C]methylation of the phenol precursor 12 with [11C]CH3I. In vitro autoradiog. with [11C]5i showed heterogeneous radioactive accumulation in the brain tissue sections, ranked in the order: cortex > striatum > hippocampus > cerebellum ≫ thalamus > pons. PET study of [11C]5i indicated in vivo specific binding of mGlu2 in the rat brain. Based on the [11C]5i scaffold, further optimization for new candidates is underway to identify a more suitable ligand for imaging mGlu2.

In addition to the literature in the link below, there is a lot of literature about this compound((6-Fluoropyridin-3-yl)methanol)Safety of (6-Fluoropyridin-3-yl)methanol, illustrating the importance and wide applicability of this compound(39891-05-9).

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Carlson, Lars A.; Hedbom, Christina; Helgstrand, Erik; Misiorny, Alfons; Sjoberg, Berndt; Stjernstrom, Nils E.; Westin, Gertrud published an article about the compound: (6-Fluoropyridin-3-yl)methanol( cas:39891-05-9,SMILESS:OCC1=CC=C(F)N=C1 ).Application of 39891-05-9. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:39891-05-9) through the article.

The pyridines I (R = CHO, CH2OH, CH2CN, CH2CO2H, CH2OCH2Ph, CH2O2CNHPh CH2O2CCMe2OC6H4Cl-p, etc.; R1 = 5-F, 6-F, 5-Cl, 6-Cl, 5-Br) were prepared Thus I (R = CH2OH, R1 = 5-F) was treated with SOCl2 and the product treated with KCN to give I (R = CH2CN, R1 = 5-F), which was hydrolyzed to give I (R = CH2CO2H, R1 = 5-F). 5-Fluoronicotinic acid and 5-fluoro-3-pyridylmethanol were oxidized with H2O2 to give the pyridine oxides (II, R = CO2H, R = CH2OH, resp.). The N-methylnicotinic acid (III) was also prepared The pharmacol. effects of the compounds on noradrenaline-induced free fatty acid mobilization in dogs was determined and related to nicotinic acid.

I hope my short article helps more people learn about this compound((6-Fluoropyridin-3-yl)methanol)Application of 39891-05-9. Apart from the compound(39891-05-9), you can read my other articles to know other related compounds.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Dimethylpyridin-4-ylamine-catalysed alcoholysis of 2-amino-N,N,N-trimethyl-9H-purine-6-ylammonium chloride: An effective route to O6-substituted guanine derivatives from alcohols with poor nucleophilicity, published in 2002-03-31, which mentions a compound: 39891-05-9, Name is (6-Fluoropyridin-3-yl)methanol, Molecular C6H6FNO, Formula: C6H6FNO.

Dimethylpyridin-4-ylamine (DMAP)-catalyzed reactions of 2-amino-N,N,N-trimethyl-9H-purine-6-ylammonium chloride with fluoropyridine methoxides and various other alkoxides in DMSO at 60 °C gave the corresponding coupling products in moderate to good yields between 20-87%. Under these reaction conditions, fluorinated O6-substituted Guanine derivatives have been synthesized which could not be obtained via known analogous literature procedures. The resp. yields of known O6-substituted guanine derivatives could be significantly improved by using this method. The efficient use of DMAP as an excellent nucleophilic catalyst in the syntheses of O6-substituted Guanine derivatives has thus been demonstrated.

There are many compounds similar to this compound(39891-05-9)Formula: C6H6FNO. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: (6-Fluoropyridin-3-yl)methanol, is researched, Molecular C6H6FNO, CAS is 39891-05-9, about Identification and Development of a New Positron Emission Tomography Ligand 4-(2-Fluoro-4-[11C]methoxyphenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide for Imaging Metabotropic Glutamate Receptor Subtype 2 (mGlu2).Safety of (6-Fluoropyridin-3-yl)methanol.

Metabotropic glutamate receptor 2 (mGlu2) is a known target for treating several central nervous system (CNS) disorders. To develop a viable positron emission tomog. (PET) ligand for mGlu2, we identified new candidates 5a-i that are potent neg. allosteric modulators (NAMs) of mGlu2. Among these candidates, 4-(2-fluoro-4-methoxyphenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide (5i, also named as [11C]MG2-1812) exhibited high potency, high subtype selectivity, and favorable lipophilicity. Compound 5i was labeled with positron-emitting carbon-11 (11C) to obtain [11C]5i in high radiochem. yield and high molar activity by O-[11C]methylation of the phenol precursor 12 with [11C]CH3I. In vitro autoradiog. with [11C]5i showed heterogeneous radioactive accumulation in the brain tissue sections, ranked in the order: cortex > striatum > hippocampus > cerebellum ≫ thalamus > pons. PET study of [11C]5i indicated in vivo specific binding of mGlu2 in the rat brain. Based on the [11C]5i scaffold, further optimization for new candidates is underway to identify a more suitable ligand for imaging mGlu2.

In addition to the literature in the link below, there is a lot of literature about this compound((6-Fluoropyridin-3-yl)methanol)Safety of (6-Fluoropyridin-3-yl)methanol, illustrating the importance and wide applicability of this compound(39891-05-9).

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Carlson, Lars A.; Hedbom, Christina; Helgstrand, Erik; Misiorny, Alfons; Sjoberg, Berndt; Stjernstrom, Nils E.; Westin, Gertrud published an article about the compound: (6-Fluoropyridin-3-yl)methanol( cas:39891-05-9,SMILESS:OCC1=CC=C(F)N=C1 ).Application of 39891-05-9. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:39891-05-9) through the article.

The pyridines I (R = CHO, CH2OH, CH2CN, CH2CO2H, CH2OCH2Ph, CH2O2CNHPh CH2O2CCMe2OC6H4Cl-p, etc.; R1 = 5-F, 6-F, 5-Cl, 6-Cl, 5-Br) were prepared Thus I (R = CH2OH, R1 = 5-F) was treated with SOCl2 and the product treated with KCN to give I (R = CH2CN, R1 = 5-F), which was hydrolyzed to give I (R = CH2CO2H, R1 = 5-F). 5-Fluoronicotinic acid and 5-fluoro-3-pyridylmethanol were oxidized with H2O2 to give the pyridine oxides (II, R = CO2H, R = CH2OH, resp.). The N-methylnicotinic acid (III) was also prepared The pharmacol. effects of the compounds on noradrenaline-induced free fatty acid mobilization in dogs was determined and related to nicotinic acid.

I hope my short article helps more people learn about this compound((6-Fluoropyridin-3-yl)methanol)Application of 39891-05-9. Apart from the compound(39891-05-9), you can read my other articles to know other related compounds.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem