Category: 39891-13-9

Related Products of 39891-13-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 39891-13-9, name is 2-(6-Chloropyridin-3-yl)acetic acid. This compound has unique chemical properties. The synthetic route is as follows.

Intermediate M-1 was synthesized through the esterification of the carboxylic acid moiety of 2-(6-chloropyridin-3-yl)acetic acid, dimethylation of the carbonyl group at the alpha-position, reduction of the ester moiety with LAH, oxidation of the resultant alcohol moiety, reductive amination with methylamine, protection with a Boc group, amination of the 2-chloropyridine moiety in the presence of a Pd catalyst, and deprotection

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 39891-13-9, 2-(6-Chloropyridin-3-yl)acetic acid.

Reference:
Patent; Teijin Pharma Limited; MIZUNO, Tsuyoshi; SHIMADA, Tomohiro; UNOKI, Gen; EBISAWA, Masaru; TAKEUCHI, Susumu; MINAMIZONO, Kunio; SASAKI, Kosuke; YOKOSAKA, Takuya; IGARASHI, Junji; MARUYAMA, Akinobu; TAKAHASHI, Hiroshi; HORIE, Kyohei; SAKAI, Yuri; (447 pag.)EP3305785; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 39891-13-9, 2-(6-Chloropyridin-3-yl)acetic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 39891-13-9, blongs to pyridine-derivatives compound. Quality Control of 2-(6-Chloropyridin-3-yl)acetic acid

To a stirred solution of 329 2-(6-chloropyridin-3-yl)acetic acid (10 g, 58.3 mmol) in 6 DCM (100 mL) and 139 MeOH (50 mL) was added 330 ((trimethylsilyl)methyl)diazene (8.3 mL, 175 mmol) at 0 C. The reaction was stirred at RT for 16 h and then the solvent was concentrated under reduced pressure. The residue was dilute with water (100 mL), extracted with EtOAc (100 mL×3), and the organic layers were collected, washed with brine (50 mL), dried over Na2SO4, filtered, and the filtrate was concentrated in vacuo. The residue was purified by flash silica gel chromatography to afford the 331 title compound as an oil. MS (ESI) m/z: 185.8 [M+H+].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39891-13-9, its application will become more common.

Reference:
Patent; Merck Sharp & Dohme Corp.; Han, Yongxin; Achab, Abdelghani; Deng, Yongqi; Fradera, Xavier; Gibeau, Craig; Hopkins, Brett A.; Li, Derun; Liu, Kun; McGowan, Meredeth A.; Sciammetta, Nunzio; Sloman, David; White, Catherine; Zhang, Hongjun; Zhou, Hua; US2019/144433; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem