Category: 39901-94-5

Name: Picolinoyl chloride hydrochloride. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Picolinoyl chloride hydrochloride, is researched, Molecular C6H5Cl2NO, CAS is 39901-94-5, about Ligand-controlled regiodivergence in nickel-catalyzed hydroarylation and hydroalkenylation of alkenyl carboxylic acids. Author is Li, Zi-Qi; Fu, Yue; Deng, Ruohan; Tran, Van T.; Gao, Yang; Liu, Peng; Engle, Keary M..

A nickel-catalyzed regiodivergent hydroarylation and hydroalkenylation of unactivated alkenyl carboxylic acids is reported, whereby the ligand environment around the metal center dictates the regiochem. outcome. Markovnikov hydrofunctionalization products are obtained under mild ligand-free conditions, with up to 99% yield and >20:1 selectivity. Alternatively, anti-Markovnikov products can be accessed with a novel 4,4-disubstituted Pyrox ligand I in excellent yield and >20:1 selectivity. Both electronic and steric effects on the ligand contribute to the high yield and selectivity. Mechanistic studies suggest a change in the turnover-limiting and selectivity-determining step induced by the optimal ligand. DFT calculations reveal that in the anti-Markovnikov pathway, repulsion between the ligand and the alkyl group is minimized (by virtue of it being 1° vs. 2°) in the rate- and regioselectivity-determining transmetalation transition state.

This compound(Picolinoyl chloride hydrochloride)Name: Picolinoyl chloride hydrochloride was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Picolinoyl chloride hydrochloride, is researched, Molecular C6H5Cl2NO, CAS is 39901-94-5, about Supramolecular wiring of benzo-1,3-chalcogenazoles through programmed chalcogen bonding interactions.Application of 39901-94-5.

The high-yielding synthesis of 2-substituted benzo-1,3-tellurazoles and benzo-1,3-selenazoles through a dehydrative cyclization reaction has been reported, giving access to a large variety of benzo-1,3-chalcogenazoles. Exceptionally, these aromatic heterocycles proved to be very stable and thus very handy to form controlled solid-state organizations in which wire-like polymeric structures are formed through secondary N…Y bonding interactions (SBIs) engaging the chalcogen (Y = Se or Te) and nitrogen atoms. In particular, it has been shown that the recognition properties of the chalcogen center at the solid state could be programmed by selectively barring one of its σ-holes through a combination of electronic and steric effects exerted by the substituent at the 2-position. As predicted by the electrostatic potential surfaces calculated by quantum chem. modeling, the pyridyl groups revealed to be the stronger chalcogen bonding acceptors, and thus the best ligand candidate for programming the mol. organization at the solid state. In contrast, the thiophenyl group is an unsuitable substituent for establishing SBIs in this mol. system as it gives rise to chalcogen-chalcogen repulsion. The weaker chalcogen donor properties of the Se analogs trigger the formation of feeble N…Se contacts, which are manifested in similar solid-state polymers featuring longer nitrogen-chalcogen distances.

《Supramolecular wiring of benzo-1,3-chalcogenazoles through programmed chalcogen bonding interactions》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Picolinoyl chloride hydrochloride)Application of 39901-94-5.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Novel Metal-Linked Face-to-Face Porphyrazine Dimer, published in 2005-11-14, which mentions a compound: 39901-94-5, Name is Picolinoyl chloride hydrochloride, Molecular C6H5Cl2NO, Product Details of 39901-94-5.

We report the synthesis and phys. studies of a novel copper nickel porphyrazine dimer [NiCuL]2 (H4L = I) which has Ni(II) ions incorporated into the porphyrazine cores and is linked by two Cu(II) ions coordinated to bis(picolinamide) chelates attached to the porphyrazine periphery. The crystal structures of the dimer and the precursor metal-free porphyrazine ligand are presented. The dimer consists of parallel, face-to-face porphyrazines with an average separation of 3.30 Å which are linked through the peripheral picolinamide ligands by a pair of peripheral Cu(II) ions. Each Cu(II) is coordinated with distorted square-planar geometry by a picolinamide from each porphyrazine. In this report we focus on the interaction of these two peripheral Cu(II) ions. We discuss the preparation and magnetic properties of the porphyrazine dimer complex with two Cu(II) ions in the peripheral chelate a diamagnetic metal ion Ni(II) in the porphyrazine core. Although the dimer contains two Cu(II) ions (S = 1/2) we could detect no ESR signal which suggests very strong antiferromagnetic exchange between those two Cu(II) ions. Temperature-dependent magnetic susceptibility measurement gives an exchange splitting between the S = 0 ground state and the excited triplet state of Δ = 660 cm-1.

《Novel Metal-Linked Face-to-Face Porphyrazine Dimer》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(Picolinoyl chloride hydrochloride)Product Details of 39901-94-5.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Hoffelner, Michael; Petritsch, Markus; Ahmad, Sarfraz; Seebacher, Werner; Dolensky, Johanna; Hochegger, Patrick; Kaiser, Marcel; Maeser, Pascal; Saf, Robert; Weis, Robert researched the compound: Picolinoyl chloride hydrochloride( cas:39901-94-5 ).Related Products of 39901-94-5.They published the article 《New derivatives of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities》 about this compound( cas:39901-94-5 ) in Monatshefte fuer Chemie. Keywords: azabicyclononane derivative preparation SAR antiplasmodial antitrypanosomal. We’ll tell you more about this compound (cas:39901-94-5).

New derivatives of 3-azabicyclo[3.2.2]nonanes such as I [R = pyridin-2-yl, pyridin-3-yl, pyridin-4-yl] were prepared and characterized using FT-IR spectroscopy, HRMS, and NMR spectroscopy. The new compounds were investigated in vitro for their antiplasmodial activities against sensitive NF54 strain and multiresistant K1 strain of Plasmodium falciparum, and for their antitrypanosomal activity against Trypanosoma brucei rhodesiense. Compound I [R = pyridin-4-yl] possessed high antiplasmodial in vitro activity against both strains of P. falciparum (NF54: IC50 = 0.848 nm; K1: IC50 = 2 nm). The most promising ones were further investigated in a mouse model for their in vivo activity against Plasmodium berghei.

Different reactions of this compound(Picolinoyl chloride hydrochloride)Related Products of 39901-94-5 require different conditions, so the reaction conditions are very important.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C6H5Cl2NO. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Picolinoyl chloride hydrochloride, is researched, Molecular C6H5Cl2NO, CAS is 39901-94-5, about Tridentate Directing Groups Stabilize 6-Membered Palladacycles in Catalytic Alkene Hydrofunctionalization. Author is O’Duill, Miriam L.; Matsuura, Rei; Wang, Yanyan; Turnbull, Joshua L.; Gurak, John A.; Gao, De-Wei; Lu, Gang; Liu, Peng; Engle, Keary M..

Removable tridentate directing groups inspired by pincer ligands have been designed to stabilize otherwise kinetically and thermodynamically disfavored 6-membered alkyl palladacycle intermediates. This family of directing groups enables regioselective remote hydrocarbofunctionalization of several synthetically useful alkene-containing substrate classes, including 4-pentenoic acids, allylic alcs., homoallyl amines, and bis-homoallylamines, under Pd(II) catalysis. In conjunction with previous findings, we demonstrate regiodivergent hydrofunctionalization of 3-butenoic acid derivatives to afford either Markovnikov or anti-Markovnikov addition products depending on directing group choice. Preliminary mechanistic and computational data are presented to support the proposed catalytic cycle.

The article 《Tridentate Directing Groups Stabilize 6-Membered Palladacycles in Catalytic Alkene Hydrofunctionalization》 also mentions many details about this compound(39901-94-5)Formula: C6H5Cl2NO, you can pay attention to it, because details determine success or failure

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Naettinen, Kalle I.; Rissanen, Kari researched the compound: Picolinoyl chloride hydrochloride( cas:39901-94-5 ).Category: pyridine-derivatives.They published the article 《Chloride-hydrogen interactions of picolinic, nicotinic and isonicotinic acid chloride hydrochlorides in the crystalline state》 about this compound( cas:39901-94-5 ) in CrystEngComm. Keywords: picolinic acid chloride hydrochloride crystallog chloride hydrogen interaction; nicotinic acid chloride hydrochloride crystallog chloride hydrogen interaction; isonicotinic acid chloride hydrochloride crystallog chloride hydrogen interaction. We’ll tell you more about this compound (cas:39901-94-5).

The crystal structures of the three isomers of the chem. labile pyridinecarboxylic acid chloride hydrochlorides were analyzed in order to study the weak interactions of the chloride anion with hydrogens. The chloride anions in the crystal structure of 1a have a slightly distorted square-planar interaction sphere with four hydrogens in the equatorial plane (plane of the mol.) with Cl-···H distances varying from 2.041(1)Å [NH+···Cl-] to 2.933(1) Å [CH···Cl-]. Nicotinic and isonicotinic acid chloride hydrochloride 1b and 1c show that chloride anion has a crucial role in the formation of bridged dimeric structures. The crystal lattices of 1b and 1c manifest similar herring-bone packing patterns. The chloride anions of 1b and 1c have slightly deformed planar interaction geometries to five and six hydrogens, resp., with Cl-···H distances varying from 2.334(1) and 2.385(4)Å [NH+···Cl-] to 2.781(3) and 2.833(6)Å [CH···Cl-] in 1b and 1c, resp. The difference in the packing of the isomers was attributed to Cl-···C contacts in 1a and on the other hand to end to-end intermol. interactions of the dimers of 1b and 1c, which could not exist with herring-bone packing of 1a. The moisture sensitive crystals of 1a, 1b, and 1c were obtained by sublimation of the compounds by heating in vacuo.

The article 《Chloride-hydrogen interactions of picolinic, nicotinic and isonicotinic acid chloride hydrochlorides in the crystalline state》 also mentions many details about this compound(39901-94-5)Category: pyridine-derivatives, you can pay attention to it, because details determine success or failure

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Picolinoyl chloride hydrochloride, is researched, Molecular C6H5Cl2NO, CAS is 39901-94-5, about New SIRT2 inhibitors: Histidine-based bleomycin spin-off.Electric Literature of C6H5Cl2NO.

Bleomycin is considered to exert its antitumor activity via DNA cleavage mediated by activated oxygen generated from the iron complex in its chelator moiety. Spin-offs from this moiety, HPH-1Trt and HPH-2Trt, with anti-cancer activities were recently synthesized. In this paper, we developed inhibitors of NAD-dependent deacetylase isoform 2 of Sirtuin protein (SIRT2), based on HPH-1Trt/HPH-2Trt, and aimed to generate new anti-cancer drugs. HPH-1Trt and HPH-2Trt had in vitro anti-SIRT2 inhibitory activity with 50% inhibitory concentration (IC50) values of 5.5 and 8.8 μM, resp. A structural portion of HPH-1Trt/HPH-2Trt, a tritylhistidine derivative TH-1, had stronger activity (IC50 = 1.7 μM), and thus, fourteen derivatives of TH-1 were synthesized. Among them, TH-3 had the strongest activity (IC50 = 1.3 μM). Selective binding of TH-3 in the pocket of SIRT2 protein was confirmed with a mol. docking study. Furthermore, TH-3 strongly lowered viability of the breast cancer cell line MCF7 with an IC50 of 0.71 μM. A structure-activity relationship study using cell lines suggested that the mechanism of TH-3 to suppress MCF7 cells involves not only SIRT2 inhibition, but also another function. This compound may be a new candidate anti-cancer drug.

The article 《New SIRT2 inhibitors: Histidine-based bleomycin spin-off》 also mentions many details about this compound(39901-94-5)Electric Literature of C6H5Cl2NO, you can pay attention to it or contacet with the author([email protected]; [email protected]) to get more information.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of the American Chemical Society called Allene C(sp2)-H Activation and Alkenylation Catalyzed by Palladium, Author is Schreib, Benedikt S.; Son, Mina; Aouane, Francoise A.; Baik, Mu-Hyun; Carreira, Erick M., which mentions a compound: 39901-94-5, SMILESS is O=C(Cl)C1=NC=CC=C1.[H]Cl, Molecular C6H5Cl2NO, Related Products of 39901-94-5.

Herein, a Pd-catalyzed C-H alkenylation of electronically unbiased allenes e.g., N-(6-(triisopropylsilyl)hepta-4,5-dien-1-yl)picolinamide, affording penta-1,2,4-triene products e.g., I in up to 94% yield was reported. A picolinamide directing group enables the formation of putative allenyl-palladacycles, which subsequently participate in a turnover limiting Heck-type reaction with electron-deficient alkene RCH=CH2 (R = methoxycarbonyl, (benzyloxy)carbonyl, [(4-methyl-2-oxo-2H-chromen-7-yl)oxy]carbonyl, etc.) coupling partners. This mechanistic proposal is consistent with exptl. and computational investigations. Addnl., for the first time, the use of picolinamide N,O-acetals as readily removable auxiliaries for C-H activation reactions, allowing the efficient alkenylation of allenyl carbinol derivatives was reported. Successful removal of the directing groups without affecting the reactive penta-1,2,4-triene substructure of the products e.g., I was demonstrated.

Although many compounds look similar to this compound(39901-94-5)Related Products of 39901-94-5, numerous studies have shown that this compound(SMILES:O=C(Cl)C1=NC=CC=C1.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: Picolinoyl chloride hydrochloride. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Picolinoyl chloride hydrochloride, is researched, Molecular C6H5Cl2NO, CAS is 39901-94-5, about Polyisophthalamides with heteroaromatic pendent rings: Synthesis, physical properties, and water uptake. Author is Ferreiro, Juan J.; De La Campa, Jose G.; Lozano, Angel E.; De Abajo, Javier.

A set of novel aromatic polyamides containing pyridine pendent groups was prepared from aromatic diamines and new monomers that are 5-substituted derivatives of isophthalic acid bearing nicotinamide, isonicotinamide, or picolinamide groups. The polymers were obtained in high yield and high mol. weight by the phosphorylation method of polycondensation. They were characterized by spectroscopic and chromatog. methods and several of their properties were investigated. All of the polymers were soluble in polar aprotic solvents and gave films of good mech. properties. Glass transition temperatures were higher than that of the reference polymer, poly(m-phenyleneisophthalamide) (IP-MPD), while the thermal resistance, defined by the initial decomposition temperature observed by thermogravimetry, was in the range 370°-420°, lower by 30°-70° than that of IP-MPD. The presence of a pendent pyridine group and an addnl. amide side group per repeat unit made the polymers essentially amorphous and greatly improved their abilities to absorb water in comparison with nonsubstituted polyamides. Water uptake values up to 15% were observed at 65% relative humidity.

Although many compounds look similar to this compound(39901-94-5)Name: Picolinoyl chloride hydrochloride, numerous studies have shown that this compound(SMILES:O=C(Cl)C1=NC=CC=C1.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Holtrichter-Roessmann, Thorsten; Haeger, Ina; Daniliuc, Constantin-Gabriel; Froehlich, Roland; Bergander, Klaus; Troll, Carsten; Rieger, Bernhard; Rojas, Rene S.; Wuerthwein, Ernst-Ulrich published an article about the compound: Picolinoyl chloride hydrochloride( cas:39901-94-5,SMILESS:O=C(Cl)C1=NC=CC=C1.[H]Cl ).Synthetic Route of C6H5Cl2NO. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:39901-94-5) through the article.

Three novel N-acylamidines 1a-c with varying steric bulk and substitution patterns were synthesized and thoroughly characterized by X-ray diffraction. N-Acylamidines RNHCpy:NCOpy (1a, 1b, py = 2-pyridyl, R = 1-adamantyl, Ph), which contain two addnl. binding sites located at two pyridine substituents, were treated with equimolar amounts of cyclopentadienylzirconium(IV) trichloride at room temperature The X-ray data of the resulting coordination compounds 7a and 7b indicate the formation of five-membered metallacycles with one of the pyridine nitrogen atoms and the carbonyl oxygen atom acting as binding sites. For the complexation of ligand PhCON:CPhNHAr (1c, Ar = 2,6-Me2C6H3) a different route was chosen: 1c was first deprotonated to yield the polymeric potassium compound (8) with a very complex substitution pattern based on O , N, and aromatic interactions with the potassium ions. Transmetalation of 8 with cyclopentadienylzirconium(IV) trichloride gave amidinate complex 9, which is dimeric in the solid state but exists in solution in equilibrium with monomeric species. After addition of methylaluminoxane (MAO), the three novel cyclopentadienylzirconium complexes 7a, 7b, and 9 gave active homogeneous single-site catalysts for the polymerization of ethylene. Of these three systems, 9/MAO turned out to be the most efficient one, showing activities 3-5 times higher than 7a/MAO and 7b/MAO, resp., and producing polymers with a well-defined “”monomodal”” mol. weight distribution. An important feature of these materials is their broader distribution in mol. weight (PDI > 3), which is best seen in the products of reactions at 53°, with a “”monomodal”” main fraction at higher mol. weight and only small fractions of low mol. weight

Although many compounds look similar to this compound(39901-94-5)Synthetic Route of C6H5Cl2NO, numerous studies have shown that this compound(SMILES:O=C(Cl)C1=NC=CC=C1.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem