Category: 39919-70-5

On July 21, 2022, Fasching, Bernhard; Ryckmans, Thomas; Flohr, Alexander; Ritzen, Andreas; Harvey, Freya; McAllister, Laura published a patent.Recommanded Product: 6-(tert-Butyl)pyridin-3-amine The title of the patent was Preparation of isoindolinone compounds as modulators of cereblon. And the patent contained the following:

This invention relates to the title compounds I [X1 = (un)substituted alkyl, cycloalkyl, aryl, etc.; or X1 together with the N atom of the carbamate forms (un)substituted 4-8 membered heterocycloalkyl; X2 = H, (un)substituted cycloalkyl, aryl, etc.; L1 = a covalent bond, alkyl; L2 = a covalent bond, alkyl; L3 = a covalent bond, alkyl, O, etc.] or pharmaceutically acceptable salts or stereoisomers thereof, useful as modulators of cereblon, in particular in the treatment of abnormal cell growth in mammals, especially humans. E.g., a multi-step synthesis of II, starting from Me 5-bromo-2-methylbenzoate, was described. Exemplified compounds I were tested for their ability for cereblon binding (data given for representative compounds I). Pharmaceutical composition comprising compound I was disclosed. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Recommanded Product: 6-(tert-Butyl)pyridin-3-amine

The Article related to isoindolinone dioxopiperidinyl preparation cereblon modulator anticancer, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 6-(tert-Butyl)pyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Van der Does, L.; Den Hertog, H. J. published an article in 1972, the title of the article was Didehydrohetarenes. XXV. Amination of alkyl substituted halopyridines with potassium amide in liquid ammonia.Quality Control of 6-(tert-Butyl)pyridin-3-amine And the article contains the following content:

The action of KNH2 in liquid NH3 on Me substituted 3- and 4-bromo(or chloro)pyridines, of 5-bromo-2-tert-butylpyridine and of 3-bromo(or chloro) and 4-bromo(or chloro)-2,6-dimethylpyridine was studied. The results of the reactions indicate the occurrence of derivatives of 3,4-didehydropyridine as intermediates. An interpretation is given of the influence of the substituent and the hetero atom on the course of the aminations. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Quality Control of 6-(tert-Butyl)pyridin-3-amine

The Article related to hetarene didehydro, amination alkylhalopyridine, pyridine alkylhalo amination, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Quality Control of 6-(tert-Butyl)pyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 24, 2009, Yuan, Chester Chenguang published a patent.Name: 6-(tert-Butyl)pyridin-3-amine The title of the patent was Preparation of substituted arylamine derivatives, particularly 2-aminonicotinamides, as antitumor agents. And the patent contained the following:

The invention is related to the preparation of a compound or a pharmaceutically acceptable derivative thereof, wherein the compound is 3-[(7-isoquinolinyl)amino]-N-[3-methyl-4-(1-methylethyl)phenyl]-3-pyridinecarboxamide are prepared and to its use as an effective agent for treatment of angiogenesis and related diseases such as cancer. Thus, acylation of 7-amino-4,4-dimethyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-Bu ester with 2-chloropyridine-3-carbonyl chloride, followed by amination of the chloride intermediate (no data) with 7-aminoisoquinoline and deprotection gave 2-[(7-isoquinolinyl)amino]-N-(1,2,3,4-tetrahydro-4,4-dimethyl-7-isoquinolinyl)-3-piperidinecarboxamide monohydrochloride. Selected compounds of the invention inhibited VEGF-stimulated HUVEC proliferation at a level below 1 μM. In the tumor model, compounds of the invention are active at doses less than 150 mpk. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Name: 6-(tert-Butyl)pyridin-3-amine

The Article related to arylamine preparation antitumor angiogenesis inhibitor, pyridinecarboxamide amino preparation neoplasm vegf inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Name: 6-(tert-Butyl)pyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 7, 2017, Kato, Taku; Sakamoto, Toshiaki; Niwa, Yasuki; Sawamoto, Daisuke; Otani, Naohito; Kanbe, Misaki published a patent.COA of Formula: C9H14N2 The title of the patent was Preparation of aromatic carboxylic acid amides having TRPM8 blocking effect. And the patent contained the following:

Disclosed are compounds I [ring A = benzene or thiophene; X1 = CR11 or nitrogen atom; R11 = H or (un)substituted alkyl; X2, X3 = independently CH or nitrogen atom; ring C = monocyclic ring; R1 = (un)substituted alkyl, (un)substituted alkanoyl, cyano, etc.; R1 is substituted on the adjacent position to the point of attachment to ring B; R2 = H, (un)substituted alkyl or halo; R3 = cyano, -Ra, -N(Rb)(Rc), etc.; Ra = (un)substituted alkyl, (un)substituted non-aromatic heterocycle-methyl-, (un)substituted alkenyl, etc.; Rb = (un)substituted alkyl, (un)substituted alkenyl, (un)substituted cycloalkyl, etc.; Rc = H, (un)substituted alkyl, (un)substituted alkenyl, etc.; R4 = (un)substituted alkyl, (un)substituted alkanoyl, cyano, etc.; n = 0 or 1; R5 = H, (un)substituted alkyl, hydroxy, etc.; when n is 1, R4 and R5, together with ring C, may combine to form a bicyclic ring; or pharmacol. acceptable salts thereof]. For example, compound II was prepared from 5-bromo-3-fluoropyridine-2-carboxylic acid Et ester via conversion into 3-iodo-5-[2-(trifluoromethyl)phenyl]pyridine-2-carboxylic acid followed by amidation with 5-amino-2-trifluoromethylpyridine and reaction with 5-methyl-2-pyrrolidone. In TRPM8 blocking test, 361-example of I showed IC50 values (nmol/L) ranging from 0.2 to 2760, e.g., IC50 of II was 4 nmol/L. Of note, compounds I are useful for the treatment of chronic pain. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).COA of Formula: C9H14N2

The Article related to aromatic carboxylic acid amide preparation trpm8 blocker, chronic pain treatment aromatic carboxylic acid amide trpm8 blocking, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.COA of Formula: C9H14N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 17, 2016, Kato, Taku; Sakamoto, Toshiaki; Niwa, Yasuki; Sawamoto, Daisuke; Ohtani, Naohito; Kanbe, Misaki published a patent.HPLC of Formula: 39919-70-5 The title of the patent was Preparation of aromatic carboxylic acid amides having TRPM8 blocking effect. And the patent contained the following:

Disclosed are compounds I [ring A = benzene or thiophene; X1 = CR11 or nitrogen atom; R11 = H or (un)substituted alkyl; X2, X3 = independently CH or nitrogen atom; ring C = monocyclic ring; R1 = (un)substituted alkyl, (un)substituted alkanoyl, cyano, etc.; R1 is substituted on the adjacent position to the point of attachment to ring B; R2 = H, (un)substituted alkyl or halo; R3 = cyano, -Ra, -N(Rb)(Rc), etc.; Ra = (un)substituted alkyl, (un)substituted non-aromatic heterocycle-methyl-, (un)substituted alkenyl, etc.; Rb = (un)substituted alkyl, (un)substituted alkenyl, (un)substituted cycloalkyl, etc.; Rc = H, (un)substituted alkyl, (un)substituted alkenyl, etc.; R4 = (un)substituted alkyl, (un)substituted alkanoyl, cyano, etc.; n = 0 or 1; R5 = H, (un)substituted alkyl, hydroxy, etc.; when n is 1, R4 and R5, together with ring C, may combine to form a bicyclic ring; or pharmacol. acceptable salts thereof]. For example, compound II was prepared from 5-bromo-3-fluoropyridine-2-carboxylic acid Et ester via conversion into 3-iodo-5-[2-(trifluoromethyl)phenyl]pyridine-2-carboxylic acid followed by amidation with 5-amino-2-trifluoromethylpyridine and reaction with 5-methyl-2-pyrrolidone. In TRPM8 blocking test, 361-example of I showed IC50 values (nmol/L) ranging from 0.2 to 2760, e.g., IC50 of II was 4 nmol/L. Of note, compounds I are useful for the treatment of chronic pain. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).HPLC of Formula: 39919-70-5

The Article related to aromatic carboxylic acid amide preparation trpm8 blocker, chronic pain treatment aromatic carboxylic acid amide trpm8 blocking, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 39919-70-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 21, 2022, Gavory, Gerald; Ghandi, Mahmoud; Chicas, Agustin; Warmuth, Markus published a patent.HPLC of Formula: 39919-70-5 The title of the patent was Preparation of isoindolinone compounds for treating Myc-driven cancers with GSPT1 degraders. And the patent contained the following:

The present disclosure relates to new methods to predict the responsiveness of cancer patients to GSPT1 neg. modulators and thus determine the of efficacy GSPT1 neg. modulators to treat cancer patients by determining the level of one or more biomarkers in samples of the patients. The present disclosure also relates to applications of these methods, which includes stratifying cancer malignancies, in particular identifying Myc-driven cancers, and thereby devising optimized and personalized treatments for these cancer patients, as well as optimizing the selection of patient populations for resp. clin. trials. The title compounds I [X1 = (un)substituted alkyl, cycloalkyl, aryl, etc.; or X1 together with X4 forms (un)substituted 4-8 membered heterocycloalkyl; X2 = H, cycloalkyl, aryl, etc.; X3 = NH, O; X4 = NH, CH2; X5 = H, alkyl, alkoxy, CN, etc.; L1 and L2 = (independently) a covalent bond, (un)substituted alkylene; L3 = a covalent bond, O, (un)substituted alkylene, etc.] or pharmaceutically acceptable salts or stereoisomers thereof, were prepared E.g., a multi-step synthesis of II, starting from Me 5-bromo-2-methylbenzoate, was described. Exemplified compounds I were tested for their ability for cereblon binding (data given for representative compounds I). The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).HPLC of Formula: 39919-70-5

The Article related to isoindolinone dioxopiperidinyl preparation cereblon modulator anticancer myc driven cancer, gspt1 degrader modulator biomaker isoindolinone dioxopiperidinyl preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 39919-70-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 15, 2014, Cha, Sun Uk; Jung, Gyeong Seok; Park, Seok Bae; Kim, Hui Dae; Lee, Yu Rim; Song, Ju Man; Hwang, Mun Chan published a patent.Formula: C9H14N2 The title of the patent was Asymmetric pyrene derivative comprising heteroaryl amine as electroluminescent dopant for organic light-emitting device. And the patent contained the following:

The present invention relates to an asym. pyrene derivative comprising heteroaryl amine, and an organic light-emitting device comprising the same. The asym. pyrene derivative comprising heteroaryl amine is represented by formula I or II (Py = substituted or unsubstituted pyridinyl; Het1-Het3 = heterogeneous atom selected from oxygen, nitrogen, sulfur and silicon, C2-C50 heteroaryl group; Z = hydrogen, deuterium, C1-C30 alkyl group, C5-C50 aryl group, C2-C30 alkenyl group, C2-C20 alkynyl group, C3-C30 cycloalkyl group, C5-C30 cycloalkenyl group, etc.; m = integer of 1-8 for formula I and 1-9 for formula II, where the substitution is selected from deuterium, cyano group, halogen, hydroxyl group, nitro group, C1-C24 alkyl group, etc.). The organic light-emitting device comprises: a first electrode; a second electrode placed opposite to the first electrode; and an organic layer placed between the first and second electrodes, where the organic layer includes an organic light-emitting compound i.e. asym. pyrene derivative The organic layer is selected from hole injection layer having hole injection function, hole transport layer having hole transport function, functional layer, light-emitting layer, electron transport layer, and electron injection layer. According to the present invention, the asym. pyrene derivative has excellent luminous efficiency and high-color purity, and is utilized in the organic light-emitting device such as flat panel display device, flexible display device, monochromatic or white flexible lighting device, etc. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Formula: C9H14N2

The Article related to asym pyrene heteroaryl amine electroluminescent dopant flat panel display, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Luminescence and other aspects.Formula: C9H14N2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 15, 2014, Cha, Sun Uk; Jung, Gyeong Seok; Park, Seok Bae; Kim, Hui Dae; Lee, Yu Rim; Song, Ju Man; Hwang, Mun Chan published a patent.Safety of 6-(tert-Butyl)pyridin-3-amine The title of the patent was Amine group substituted asymmetric pyrene derivative comprising pyridinyl group as electroluminescent dopant and/or organic semiconductor materials for organic light-emitting device. And the patent contained the following:

The present invention relates to an amine group substituted asym. pyrene derivative, and an organic light-emitting device comprising the same. The amine group substituted asym. pyrene derivative comprising pyridinyl group is represented by formula I (Py1, Py2 = substituted or unsubstituted pyridinyl group; Ar1, Ar2 = substituted or unsubstituted C1-C30 alkyl group, substituted or unsubstituted C3-C30 cycloalkyl group, substituted or unsubstituted C5-C50 aryl group, C2-C50 heteroaryl group having one or more substituted or unsubstituted atoms selected from oxygen, nitrogen, sulfur and silicon; Z = hydrogen, deuterium, substituted or unsubstituted C1-C30 alkyl group, substituted or unsubstituted C5-C50 aryl group, substituted or unsubstituted C2-C30 alkenyl group, substituted or unsubstituted C2-C20 alkynyl group, substituted or unsubstituted C3-C30 cycloalkyl group, substituted or unsubstituted C5-C30 cycloalkenyl group, etc.; and m = integer of 1-8, where the substituted or unsubstituted substitution is selected from deuterium, cyano group, halogen, hydroxyl group, nitro group, C1-C24 alkyl group, etc.). The organic light-emitting device comprises: a first electrode; a second electrode placed opposite to the first electrode; and an organic layer placed between the first and second electrodes, where the organic layer includes an organic light-emitting compound i.e. amine group substituted asym. pyrene derivative The organic layer is selected from hole injection layer having hole injection function, hole transport layer having hole transport function, functional layer, light-emitting layer, electron transport layer, and electron injection layer. According to the present invention, the amine group substituted asym. pyrene derivative has excellent luminous efficiency and high-color purity, and is utilized in the organic light-emitting device for producing full-color display. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Safety of 6-(tert-Butyl)pyridin-3-amine

The Article related to amine group asym pyrene derivative pyridinyl electroluminescent dopant oled, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Luminescence and other aspects.Safety of 6-(tert-Butyl)pyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On April 15, 2021, Flohr, Alexander; Eidam, Olive; Fasching, Bernhard; Meniconi, Mirco; Sadok, Amine; Chopra, Rajesh; Zhuai Wang, Hannah; Caldwell, John Jamieson; Collins, Ian; Ryckmans, Thomas published a patent.Recommanded Product: 39919-70-5 The title of the patent was Isoindolinone compounds as cereblon inhibitors and GSPT1 degraders and their preparation. And the patent contained the following:

Disclosed herein is a compound of formula I or pharmaceutically acceptable salts or stereoisomers thereof. Compounds of formula I wherein X1 is (un)branched C1-6 alkyl, C3-6 cycloalkyl, -C1-6 alkyl-C3-6 cycloalkyl, C6-10 aryl, 5- to 10-membered heteroaryl, etc.; X2 is H, C6-10 aryl, 5- to 10-membered heteroaryl, 5- to 10-membered heteroaryloxy, 4- to 8-membered heterocycloalkyl, etc.; n is 0, 1 and 2; and pharmaceutically acceptable salts, and stereoisomers thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their cereblon inhibitory activity and GSPT1 degradation activity. From the assay, it was determined that compound II exhibited IC50 value of 1037 nM and a DC50 value of > 300 nM. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Recommanded Product: 39919-70-5

The Article related to isoindolinone preparation cereblon inhibitor gspt1 degrader, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 39919-70-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem