Category: 39977-44-1

Reference of 39977-44-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.39977-44-1, name is Methyl 6-(hydroxymethyl)picolinate, molecular formula is C8H9NO3, molecular weight is 167.16, as common compound, the synthetic route is as follows.

Compound 2 (661 mg, 3.95 mmol) and 2-iodoxybenzoic (IBX 2.77 g, 9.89 mmol) were stirred in ethyl acetate (50 mL) at 80 C for 3 h. When the reaction was completed, the solid was removed by filtration. The organic phases were evaporated to dryness to give white powder-like solid 9 (640 mg). yield: 98%. 1H NMR (400 MHz, CDCl3) delta 10.20 (s, 1H), 8.36 (dd, J 7.7, 1.1 Hz, 1H), 8.16 (dd, J 7.7,1.1 Hz, 1H), 8.06 (t, J 7.7 Hz, 1H), 4.07 (s, 3H).

The chemical industry reduces the impact on the environment during synthesis 39977-44-1, I believe this compound will play a more active role in future production and life.

Reference:
Article; Shi, Xiu-Fang; Wang, Ming-Ming; Huang, Shu-chao; Han, Jiang-Xue; Chu, Wen-Chao; Xiao, Chunling; Zhang, En; Qin, Shangshang; European Journal of Medicinal Chemistry; vol. 167; (2019); p. 367 – 376;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 39977-44-1, Methyl 6-(hydroxymethyl)picolinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of Methyl 6-(hydroxymethyl)picolinate, blongs to pyridine-derivatives compound. Application In Synthesis of Methyl 6-(hydroxymethyl)picolinate

EXAMPLE 18 Preparation of 6-formylpyridine-2-carboxylic Acid Methyl Ester (IVo) A solution of 3 g of 6-hydroxymethylpyridine-2-carboxylic acid methyl ester (16.5 mmol) in 70 ml of 1,2-dichloroethane containing 15 g of manganese dioxide (165 mmol) is heated under reflux for 4 hours with removal of the water formed continuously. The solid is removed by filtration on celite and then the dichloromethane is evaporated off. The title product is isolated by chromatography on a silica column (eluent: dichloromethane/ethyl acetate; 70:30). 2.33 g of a yellow oil are recovered. Yield: 79% 1 H NMR (CDCl3) delta: 1.36 (t, 3H); 4.41 (m, 2H); 8.13 (dd, 1H); 8.24 (t, 1H); 8.32 (dd, 1H); 10.02 (s, 1H). IR (film) ?: 1700 cm-1 (C=O).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,39977-44-1, Methyl 6-(hydroxymethyl)picolinate, and friends who are interested can also refer to it.

Reference:
Patent; Pierre Fabre Medicament; US6020345; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem