Category: 3998-90-1

Application of 3998-90-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3998-90-1, name is Methyl 2-chloro-6-picoline-4-carboxylate, molecular formula is C8H8ClNO2, molecular weight is 185.61, as common compound, the synthetic route is as follows.

Methyl 2-chloro-6-methylpyridin-4-carboxylate (15.0 g, 80.8 mmol), 10% palladium carbon powder (50% water containing product) (5.00 g), and triethylamine (22.5 mL, 162 mmol) were stirred in N,N-dimethylformamide (200 mL) under hydrogen atmosphere, at room temperature, for 15 h. The mixture was filtered, and the solvent was removed by evaporation under reduced pressure. The residue was purified by silica gel chromatography (ethyl acetate: methanol= 100:0-50:1) to give the title compound (14.8 g, 61%) as an oil. 1H NMR (CDCl3) d: 2.64 (3H, s), 3.95 (3H, s), 7.64 (1H, dd, J =5.2, 0.8 Hz), 7.72 (1H, s), 8.65 (1H, d, J = 4.7 Hz).

Statistics shows that 3998-90-1 is playing an increasingly important role. we look forward to future research findings about Methyl 2-chloro-6-picoline-4-carboxylate.

Reference:
Article; Kaieda, Akira; Takahashi, Masashi; Takai, Takafumi; Goto, Masayuki; Miyazaki, Takahiro; Hori, Yuri; Unno, Satoko; Kawamoto, Tomohiro; Tanaka, Toshimasa; Itono, Sachiko; Takagi, Terufumi; Hamada, Teruki; Shirasaki, Mikio; Okada, Kengo; Snell, Gyorgy; Bragstad, Ken; Sang, Bi-Ching; Uchikawa, Osamu; Miwatashi, Seiji; Bioorganic and Medicinal Chemistry; vol. 26; 3; (2018); p. 647 – 660;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3998-90-1, name is Methyl 2-chloro-6-picoline-4-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C8H8ClNO2

A mixture of methyl 2-chloro-6-methyl-pyridine-4-carboxylate (1.8 g, 10 mmol) and 10% palladium-on-charcoal catalyst (200 mg) in methanol (100 ml) was stirred under hydrogen at 5 atmospheres pressure. The catalyst was removed by filtration and the volatiles removed from the filtrate by evaporation. The residue was treated with 10% aqueous sodium hydroxide solution and extracted with ether (3*30 ml). The combined extracts were dried (MgSO4) and the solvent removed by evaporation to give methyl 2-methyl-pyridine-4-carboxylate (800 mg, 53%) as an oil.

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Reference:
Patent; Zeneca Limited; Zeneca Pharma S.A.,; US5962458; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem