Category: 40154-84-5

The author of 《Catalytic enantioselective borane reduction of benzyl oximes: preparation of (S)-1-pyridin-3-yl-ethylamine bis hydrochlorideã€?were Huang, Kun; Ortiz-Marciales, Margarita. And the article was published in Organic Syntheses in 2010. Quality Control of (S)-1-(Pyridin-3-yl)ethanamine dihydrochloride The author mentioned the following in the article:

The enantioselective preparation of (S)-1-(pyridin-3-yl)ethylamine bis hydrochloride is achieved by chiral spiroborate ester-catalyzed borane reduction of (E)-1-(pyridin-3-yl)ethanone O-benzyl-oxime in 88% yield, and 94% ee. In the part of experimental materials, we found many familiar compounds, such as (S)-1-(Pyridin-3-yl)ethanamine dihydrochloride(cas: 40154-84-5Quality Control of (S)-1-(Pyridin-3-yl)ethanamine dihydrochloride)

(S)-1-(Pyridin-3-yl)ethanamine dihydrochloride(cas: 40154-84-5) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 â†?R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Quality Control of (S)-1-(Pyridin-3-yl)ethanamine dihydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Optically active amines. XIV. Circular dichroism of 1-(2-, 3-, and 4-pyridyl)ethylamine and some related compounds》 was published in Journal of the American Chemical Society in 1973. These research results belong to Smith, Howard E.; Schaad, L. J.; Banks, R. Bruce; Wiant, Christopher J.; Jordan, Charles F.. Application of 40154-84-5 The article mentions the following:

Resolution with tartaric acid gave (S)-(-)-1-(2-, 3-, and 4-pyridyl)ethylamine and (R)-(+)-1-(3-pyridyl)ethylamine (I). The uv (isotropic absorption) and CD spectra of (S)-(+)-N-salicylidene-1-(2-pyridyl)ethylamine and (S)-(+)-N-(5-bromosalicylidene)-1-(4-pyridyl)ethylamine were examined These are similar to those of (S)-(+)-N-salicylidene-α-phenylethylamine, indicating that the CD spectra of such Schiff base derivatives may also be used for the establishment of the absolute configurations of chiral pyridyl-substituted alkylamines. 1-(4-Pyridyl)ethylamine on storage forms N-[1-(4-pyridyl)ethylidene]-1-(4-pyridyl)ethylamine by light-catalyzed oxidative process. For this reason, the racemic and optically active amines were converted to their resp. dihydrochlorides. The uv spectrum of each amine in 0.1M KOHMeOH shows an absorption maximum near 260 nm flanked by shoulders near 255 and 265 nm. These extrema are assigned to the π → π* (1Lb) transition of the pyridyl chromophore. Corresponding to each of these uv extrema, a pos. maximum is found in the CD spectra of (S)-(-)-1-(2-pyridyl)ethylamine (II) and I. For (S)-(-)-1-(3-pyridyl)ethylamine (III), the corresponding CD maximum are neg. No CD maximum was found in the spectrum of (S)-(-)-1-(4-pyridyl)ethylamine (IV) from 240 to 300 nm. In each CD spectrum there is a maximum near 240 nm, neg. for I, II, and IV and pos. for III. No corresponding absorption maximum near 240 nm was detected in any of the uv spectra. A first-order perturbation treatment of the CD spectra indicates that the 2B2 state at 180 nm makes a significant contribution to the rotational strength of the longer wavelength transitions. The CD maximum at 260 nm is due to the 1B2 ← 1A1 (π → π*) transition; the 240 nm maximum to the elec. dipole forbidden 1A2 ← 1A1 (n → π*) transition; and the rotational strength of the allowed 1B1 ← 1A1 (n → π*) transition near 288 nm is too weak to give an observable CD maximum All CD maximum disappear when the pyridine N lone pair is protonated in strong acid. After reading the article, we found that the author used (S)-1-(Pyridin-3-yl)ethanamine dihydrochloride(cas: 40154-84-5Application of 40154-84-5)

(S)-1-(Pyridin-3-yl)ethanamine dihydrochloride(cas: 40154-84-5) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Application of 40154-84-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem