Related Products of 40673-25-4 , The common heterocyclic compound, 40673-25-4, name is 4-Chloro-2-hydroxypyridine, molecular formula is C5H4ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
4-Chloro-2-hydroxy-pyridine (247 mg, 1.91 mmol), Ag2CO3 (1.58 g, 5.74 mmol) and MeI(0.13 ml, 2.11 mmol) were heated in a sealed tube at 50 0C for 16 hours and then filtered through celite and concentrated at reduced pressure. The residue was purified by FCC (Pentane/Diethyl ether with gradient, 99:1 to 95:5) to provide the title compound as colourless oil (160 mg, 58%).LCMS data: Calculated MH+ (144); Found 100% (MH+) m/z 144, Rt = 1.71 min.NMR data: 1H NMR (500 MHz, CDCl3) delta ppm 8.07 (1 H, d, J=5.5 Hz), 6.89 (1 H, dd, J=5.5,1.5 Hz), 6.77 (1 H, d, J=1.7 Hz), 3.94 (3 H, s).
The synthetic route of 40673-25-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; EVOTEC NEUROSCIENCES GMBH; WO2009/135842; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem