Category: 410092-98-7

In 2011,Advanced Synthesis & Catalysis included an article by Ohara, Mutsuyo; Nakamura, Shuichi; Shibata, Norio. Name: 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine. The article was titled 《Direct Enantioselective Three-Component Kabachnik-Fields Reaction Catalyzed by Chiral Bis(imidazoline)-Zinc(II) Catalysts》. The information in the text is summarized as follows:

A direct three-component reaction of aldehydes, amines and diaryl phosphites was catalyzed by a zinc(II) complex of 1,3-bis(imidazolin-2-yl)pyridine (pybim) giving the corresponding α-aminophosphonates in good yield with good enantioselectivity. The reaction was applied to a wide variety of aromatic aldehydes to give products with excellent yields (up to 99%) and enantiomeric excesses (up to 93% ee). The experimental process involved the reaction of 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7Name: 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine)

2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Name: 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Copper-Catalyzed Enantioselective Three-Component Synthesis of Optically Active Propargylamines from Aldehydes, Amines, and Aliphatic Alkynes》 was published in Chemistry – A European Journal in 2010. These research results belong to Nakamura, Shuichi; Ohara, Mutsuyo; Nakamura, Yuko; Shibata, Norio; Toru, Takeshi. COA of Formula: C35H27N3O2 The article mentions the following:

An enantioselective three-component reaction of aldehydes, amines, and aliphatic alkynes catalyzed by C2-sym. pybim Cu1 catalysts to give propargylamines, e.g., I in good yields and with high enantioselectivity has been developed. This process has many advantages, such as simplified operation and mild reaction conditions. These results open a novel way to synthesize optically active propargylamines. In the experiment, the researchers used many compounds, for example, 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7COA of Formula: C35H27N3O2)

2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. COA of Formula: C35H27N3O2The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Enantioselective Copper Catalyzed Alkyne-Azide Cycloaddition by Dynamic Kinetic Resolution》 was written by Liu, En-Chih; Topczewski, Joseph J.. HPLC of Formula: 410092-98-7 And the article was included in Journal of the American Chemical Society on April 3 ,2019. The article conveys some information:

In the presence of [Cu(OTf)]2·PhMe and a nonracemic bis(chlorophenyl)pyridinebis(oxazoline), allylic azides such as I underwent enantioselective azide-alkyne cycloaddition reactions via dynamic kinetic resolution to yield nonracemic allylic triazoles such as II. A nonracemic propargyl alc. and propargyl-substituted natural products underwent enantioselective azide-alkyne cycloaddition reactions in high diastereoselectivities. The azide reactants are potentially explosive and should be handled with care; reaction mixtures should not be worked up with acid to avoid the formation of hydrazoic acid and their wastes should be kept sep. from other organic wastes. The experimental part of the paper was very detailed, including the reaction process of 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7HPLC of Formula: 410092-98-7)

2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. HPLC of Formula: 410092-98-7 Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Chiral calcium catalysts with neutral coordinative ligands: enantioselective 1,4-addition reactions of 1,3-dicarbonyl compounds to nitroalkenes》 was written by Tsubogo, Tetsu; Yamashita, Yasuhiro; Kobayashi, Shu. Name: 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine And the article was included in Angewandte Chemie, International Edition in 2009. The article conveys some information:

The asym. 1,4-addition reaction of 1,3-dicarbonyl compounds to nitroalkenes was studied. Under catalytic amount of calcium salt in presence of chiral ligands, 2-substituted 1,3-dicarbonyl compounds were obtained in good yields and stereoselectivities. In the part of experimental materials, we found many familiar compounds, such as 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7Name: 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine)

2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. Name: 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine Pyridine has a conjugated system of six π electrons that are delocalized over the ring.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow-Generated Diazo Compounds and Propargylated Amines》 were Poh, Jian-Siang; Makai, Szabolcs; von Keutz, Timo; Tran, Duc N.; Battilocchio, Claudio; Pasau, Patrick; Ley, Steven V.. And the article was published in Angewandte Chemie, International Edition in 2017. Recommanded Product: 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine The author mentioned the following in the article:

The authors report the asym. coupling of flow-generated unstabilized diazo compounds and propargylated amide derivatives, using a new pyridinebis(imidazoline) ligand, a copper catalyst, and base. The reaction proceeds rapidly, generating chiral allenes in 10-20 min with high enantioselectivity (89-98 % de/ee), moderate yields and a wide functional group tolerance. In the experiment, the researchers used many compounds, for example, 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7Recommanded Product: 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine)

2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Recommanded Product: 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Poisson, Thomas; Yamashita, Yasuhiro; Kobayashi, Shu published an article in Journal of the American Chemical Society. The title of the article was 《Catalytic Asymmetric Protonation of Chiral Calcium Enolates via 1,4-Addition of Malonates》.COA of Formula: C35H27N3O2 The author mentioned the following in the article:

Nonracemic imidazolidinones such as I are prepared enantioselectively in 72-90% yields and in 48-96% ee (all but one of the ten substrates in 93-96% ee) by the addition of dibenzyl malonate to α,β-unsaturated acylimidazolidinones such as II in the presence of Py-Box ligands such as III or its enantiomer, calcium ethoxide, phenol IV, and ethanol in cyclopentyl Me ether. I is converted to various nonracemic 1,5-dicarboxylic acid derivatives such as (R)-MeO2CCHMeCH2CH2CO2H without loss of enantiopurity. The reaction is optimized on the metal salt, Py-Box ligand, phenol catalyst, added alc., solvent, and the unsaturated acyl derivative used; based on deuterium labeling studies, a mechanism for the reaction is proposed. After reading the article, we found that the author used 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7COA of Formula: C35H27N3O2)

2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. COA of Formula: C35H27N3O2The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem