Category: 4214-74-8

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4214-74-8, name is 3,5-Dichloropyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C5H4Cl2N2

K: 2-Amino-3,5-dichloropyridine J (10 g, 61.3 mmol) was dissolved in an aqueous HBr solution (100 mL 48% HBr, 200 niL H2O), then cooled to O0C. Br2 (10 mL) was added in one portion, followed by the dropwise addition OfNaNO2 solution (6.35 g, 92.0 mmol, 15 mL H2O). The mixture was stirred at O0C for 30 minutes, then allowed to warm to room temperature before being heated to 7O0C for 30 minutes. The cooled mixture was then neutralised with KOH solution (5.0 M) then extracted with ethyl acetate (3 x 200 mL), dried (MgSO4), filtered and concentrated. The residue was purified by chromatography (1:4 EtOAc, hexane) providing 8.2 g (59%) of K as a yellow crystalline solid. 1H NMR (300 MHz, CDCl3): delta 8.27 (d, J= 2.1 Hz, IH), 7.77 (d, J= 2.1 Hz, IH).

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Reference:
Patent; BIONOMICS LIMITED; WO2008/70908; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 4214-74-8 , The common heterocyclic compound, 4214-74-8, name is 3,5-Dichloropyridin-2-amine, molecular formula is C5H4Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 1: 2-bromo-3,5-dichloropyridine [0239] To a solution of 3,5-dichloropyridin-2-amine (1.0 g, 6.2 mmol) in 40% aqueous HBr (8 mL) was added dropwise bromine (2.8 g, 17 mmol) at -20C. The orange suspension was stirred for 2hrs at -20C, and followed by addition of the aqueous NaN02 (1.1 g, 17 mmol) at -20C. The mixture thus obtained was stirred for an additional 2 hours at ambient temperature. The brown mixture was basified with 30% aqueous NaOH to pH ~12 at 0C. The pale yellow mixture was extracted with ether. The combined organic phases were washed with brine, dried over Na2S04 and concentrated to afford the title compound as yellow solid (730 mg, 52%). 1H NMR (400 MHz, CDC13) delta 8.27 (d, J J= 2.3 Hz, 1H).

The synthetic route of 4214-74-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; RUGEN HOLDINGS (CAYMAN) LIMITED; SHAPIRO, Gideon; (119 pag.)WO2015/187845; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 4214-74-8 ,Some common heterocyclic compound, 4214-74-8, molecular formula is C5H4Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

PREPARATION 4 Preparation of 2-bromo-3,5-dichloropyridine 2-Bromo-3,5-dichloropyridine was prepared from 2-amino-3,5-dichloropyridine according to the method of L. C. Craig, J. Amer. Chem. Soc., 1934, 56, 231 to furnish a pale yellow crystalline solid in 76% yield, m.p. 37-38 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4214-74-8, 3,5-Dichloropyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Pfizer Inc.; US4510148; (1985); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4214-74-8, name is 3,5-Dichloropyridin-2-amine. A new synthetic method of this compound is introduced below., name: 3,5-Dichloropyridin-2-amine

Example 605-Cyano-furan-2-carboxylic acid[4-methyl-5′-(4-methyl-piperazin-l-yl)-3,4,5,6- tetrahydro-2H-[l,3′]hipyridinyl-2 ‘-yl]-amide a) 3,5-dicholoro-2-nitro pyridine; 2-Amino-3,5-dichloropyridine (193 mg, 1.00 mmol) was dissolved in cone H2SO4 (5 mL) and K2S2O8 (1.3 g, 5.0 mmol) was added portionwise. The resulting mixture was stirred at RT overnight and poured onto crushed ice and neutralized with’satd aq NaHCO3. EPO The product was extracted with CH2Cl2 (3×20 mL), dried (Na2SO4) and concentrated in vacuo to obtain the title compound (123 mg, 63.7%). 1H-NMR (CDCl3; 400 MHz): delta 8.40 (d, IH , J= 2.1 Hz), 8.05 (d, IH, J= 2.1 Hz).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4214-74-8, 3,5-Dichloropyridin-2-amine.

Reference:
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2006/47504; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem