Category: 42144-78-5

Pavia, Michael R. published the artcileN,N-Disubstituted 6-alkoxy-2-pyridinamines as anticonvulsant agents, HPLC of Formula: 42144-78-5, the main research area is alkoxypyridinamine preparation anticonvulsant; chloropyridine alkoxylation; alkoxychloropyridine aminolysis piperazine piperidine morpholine; pyridinamine alkoxy preparation anticonvulsant; aminopyridine alkoxy preparation anticonvulsant.

The anticonvulsant effect of a series of title compounds I (R = Me, Et, Me2CH, Me2CHCH2, Me2NCH2CH2, cyclopropylmethyl, cyclohexyl, cyclohexylmethyl; R1 = e.g., piperazino, piperidino, morpholino) is described. The activity/side-effect ratio in this series of compounds was optimized. I (R = Me2CHCH2; R1 = piperazino) (II) showed the most desirable profile, and was selected for a more complete pharmacol. evaluation. Overall, the pharmacol. profile of II is very similar to that of diphenylhydantoin (phenytoin). While II is nearly equipotent to phenytoin, animal studies suggest a fairly short duration of action. In addition, II exhibited some troublesome side effects including central nervous system depression and hypothermia.

Journal of Medicinal Chemistry published new progress about Alkoxylation. 42144-78-5 belongs to class pyridine-derivatives, name is 2-Chloro-6-ethoxypyridine, and the molecular formula is C7H8ClNO, HPLC of Formula: 42144-78-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Furukawa, Naomichi published the artcileSelective ipso-substitution in pyridine ring and its application for the synthesis of macrocycles containing both oxa and thia bridges, Formula: C7H8ClNO, the main research area is macrocycle oxa thio bridge; pyridine sulfinyl sulfonyl ipso substitution; sulfonylpyridine ipso substitution; sulfonylpyridine.

Both the sulfinyl and sulfonyl groups directly bound to 2 or 4 position in pyridine were readily displaced by several nucleophiles such as RO- and RS- (R = alkyl, benzyl). The facility of the leaving groups is RSO2 �RSO > Br �Cl �RS. The ipso-substitution could be applied for the synthesis of new type of 2,6-disubstituted macrocycles I (n = 1, 2, 3) in moderate yields.

Tetrahedron Letters published new progress about macrocycle oxa thio bridge; pyridine sulfinyl sulfonyl ipso substitution; sulfonylpyridine ipso substitution; sulfonylpyridine. 42144-78-5 belongs to class pyridine-derivatives, name is 2-Chloro-6-ethoxypyridine, and the molecular formula is C7H8ClNO, Formula: C7H8ClNO.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Schlosser, Manfred published the artcileThe reactivity of 2-fluoro- and 2-chloropyridines toward sodium ethoxide: Factors governing the rates of nucleophilic (het)aromatic substitutions, Related Products of pyridine-derivatives, the main research area is reactivity fluoropyridine chloropyridine sodium ethoxide nucleophilic aromatic heteroaromatic substitution.

The relative displacement rates of the halide substituent from 2-fluoro- and 2-chloropyridines by EtONa in EtOH at +25° were assessed by competition kinetics. The 2-fluoropyridine reacts 320 times faster than the chloro analog. A CF3 group increases the reactivity more than single halogen atoms do, whatever the element, and the latter are superior to Me3Si groups. Substituents accommodated at the 4-position operate through their inductive effect, whereas at the 3-position, this action may be attenuated by steric hindrance. Almost all 5-substituents enhance the rate of the nucleophilic substitution occurring at the 2-position. The sole exception concerns the F-atom at the 5-position which retards the reaction, presumably by lone-pair/lone-pair repulsion with the neg. charge building up at the central C-atom of the intermediate Meisenheimer complex. The substituent effects are additive. Therefore, by using the increments derived from the present work, the rates of future reactions should be predictable with fair accuracy.

Helvetica Chimica Acta published new progress about Ethoxylation kinetics. 42144-78-5 belongs to class pyridine-derivatives, name is 2-Chloro-6-ethoxypyridine, and the molecular formula is C7H8ClNO, Related Products of pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Schlosser, Manfred published the artcileThe reactivity of 2-fluoro- and 2-chloropyridines toward sodium ethoxide: Factors governing the rates of nucleophilic (het)aromatic substitutions, Related Products of pyridine-derivatives, the main research area is reactivity fluoropyridine chloropyridine sodium ethoxide nucleophilic aromatic heteroaromatic substitution.

The relative displacement rates of the halide substituent from 2-fluoro- and 2-chloropyridines by EtONa in EtOH at +25° were assessed by competition kinetics. The 2-fluoropyridine reacts 320 times faster than the chloro analog. A CF3 group increases the reactivity more than single halogen atoms do, whatever the element, and the latter are superior to Me3Si groups. Substituents accommodated at the 4-position operate through their inductive effect, whereas at the 3-position, this action may be attenuated by steric hindrance. Almost all 5-substituents enhance the rate of the nucleophilic substitution occurring at the 2-position. The sole exception concerns the F-atom at the 5-position which retards the reaction, presumably by lone-pair/lone-pair repulsion with the neg. charge building up at the central C-atom of the intermediate Meisenheimer complex. The substituent effects are additive. Therefore, by using the increments derived from the present work, the rates of future reactions should be predictable with fair accuracy.

Helvetica Chimica Acta published new progress about Ethoxylation kinetics. 42144-78-5 belongs to class pyridine-derivatives, name is 2-Chloro-6-ethoxypyridine, and the molecular formula is C7H8ClNO, Related Products of pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem