Category: 4373-61-9

N-Phenyl indole derivatives as AT₁ antagonists with anti-hypertension activities: Design, synthesis and biological evaluation was written by Zhu, Weibo;Bao, Xiaolu;Ren, He;Da, Yajing;Wu, Dan;Li, Fuming;Yan, Yijia;Wang, Li;Chen, Zhilong. And the article was included in European Journal of Medicinal Chemistry in 2016.HPLC of Formula: 4373-61-9 This article mentions the following:

The design, synthesis, in vitro and in vivo evaluation of 6-substituted benzimidazole with 1, 4-disubstituted or 1, 5-disubstituted indole derivatives as novel angiotensin II receptor antagonists are outlined. Radioligand binding assays showed that several 6-substituted benzimidazole derivatives displayed high affinities binding to the angiotensin II type 1 receptor at the same order of magnitude to telmisartan. The biol. evaluation on spontaneously hypertensive rats showed that 2-[4-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole-1-yl]methyl]-1H-indol-1-yl]benzoic acid, I, could cause significant decrease on MBP in a dose dependent manner. Its maximal response lowered 53 mmHg of MBP at 5 mg/kg and 64 mmHg of MBP at 10 mg/kg after oral administration, and the significant antihypertensive effect lasted beyond 24 h, which was better than both losartan and telmisartan. A study designed to determine acute toxicity showed that I had low acute toxicity with no significant changes in the weight and no obvious untoward reactions. The encouraging results make I an effective and durable anti-hypertension drug candidate and deserve further investigation for therapeutic application. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9HPLC of Formula: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.HPLC of Formula: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The C-H activated controlled mono- and di-olefination of arenes in ionic liquids at room temperature was written by Du, Kaifeng;Yao, Tian. And the article was included in RSC Advances in 2020.Application of 4373-61-9 This article mentions the following:

The controlled mono and di-olefination of arenes was first realized at room temperature via the C-H bond activation in ionic liquids, probably due to the pos. effects of ionic liquids was reported. It was an energy-saving routes in industrial production without the need for heating equipment. Different catalysts were screened, and it was found that [Ru(p-cymene)Cl₂]₂ generated mono-olefinated products predominantly while [Cp*RhCl₂]₂ selectively gave di-olefinated products. These catalysts ([BMIM]NTf₂ and [BMIM]PF₆) as green and recyclable reaction media were highly efficient under mild conditions. This reaction process was avoid any volatile and environmentally toxic organic solvents, and was much safer without the need for pressure-tight equipment. A wide substrate scope with good yields and satisfactory selectivity was achieved. The reactions was scaled up to gram-scale. Furthermore, an expensive rhodium/ruthenium catalytic system was recycled for at least 6 times with consistently high catalytic activity, which was economical and environmental friendly from an industrial point of view. According to the mechanistic study, the C-H bond cleavage was probably achieved via the concerted metalation-deprotonation. This technique was applied in the synthesis of various valuable unsaturated aromatic compounds and showed a great potential for industrial production In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Application of 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application of 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rh(III)-Catalyzed Regioselective Acetylation of sp² C-H Bond Starting from Paraformaldehyde was written by Wan, Ting;Du, Sidong;Pi, Chao;Wang, Yong;Li, Rongbin;Wu, Yangjie;Cui, Xiuling. And the article was included in ChemCatChem in 2019.Related Products of 4373-61-9 This article mentions the following:

Rh(III)-catalyzed acetylation of sp² C-H bonds has been realized using paraformaldehyde as an acetylating reagent. This procedure features simultaneous formation of two C-C bonds, external oxidants free, and water as the sole byproducts, thus offering an environmentally benign acetylation of arenes R¹R² (R¹ = pyridin-2-yl, 4-methylpyridin-2-yl, isoquinolin-1-yl; R² = Ph, 3-bromophenyl, 2,3-dihydro-1,4-benzodioxin-5-yl, etc.). A range of functional groups tolerance was observed In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Related Products of 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Related Products of 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

(Pentamethylcyclopentadienyl)cobalt(III)-Catalyzed Direct Trifluoromethylthiolation of Arenes via C-H Activation was written by Liu, Xu-Ge;Li, Qingjiang;Wang, Honggen. And the article was included in Advanced Synthesis & Catalysis in 2017.Safety of 2-(m-Tolyl)pyridine This article mentions the following:

The direct trifluoromethylthiolation of arenes was realized via (pentamethylcyclopentadienyl)cobalt(III)-catalyzed C(sp²)-H activation and coupling with AgSCF₃ under the assistance of a directing group. The reaction features redox-neutrality, mild conditions, broad substrate scope, and good functional group tolerance. Preliminary mechanistic studies have been conducted. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Safety of 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Facilitating Ir-Catalyzed C-H Alkynylation with Electrochemistry: Anodic Oxidation-Induced Reductive Elimination was written by Ye, Xiaohan;Wang, Chenhuan;Zhang, Shuyao;Wei, Jingwen;Shan, Chuan;Wojtas, Lukasz;Xie, Yan;Shi, Xiaodong. And the article was included in ACS Catalysis in 2020.Synthetic Route of C12H11N This article mentions the following:

An electrochem. approach in promoting directed C-H alkynylation with terminal alkyne via iridium catalysis is reported. This work employed anodic oxidation of Ir(III) intermediate (characterized by X-ray crystallog.) to promote reductive elimination, giving the desired coupling products in good yields (up to 95%) without the addition of any other external oxidants. This transformation is suitable for various directing groups with H₂ as the only byproduct, which warrants a high atom economy and practical oxidative C-C bond formation under mild conditions. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Synthetic Route of C12H11N).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Synthetic Route of C12H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rhodium(III)-catalyzed diverse [4+1] annulation of arenes with 1,3-enynes via sp³/sp² C-H activation and 1,4-rhodium migration was written by Bai, Dachang;Xia, Jintao;Song, Fangfang;Li, Xueyan;Liu, Bingxian;Liu, Lihong;Zheng, Guangfan;Yang, Xifa;Sun, Jiaqiong;Li, Xingwei. And the article was included in Chemical Science in 2019.Application of 4373-61-9 This article mentions the following:

Rhodium(III)-catalyzed sp² and sp³ C-H activation-oxidative annulations between aromatic substrates and 1,3-enynes, where alkenyl-to-allyl 1,4-rhodium(III) migration enabled the generation of electrophilic rhodium(III) π-allyls via remote C-H functionalization are described. Subsequent nucleophilic trapping of these species by various sp²-hybridized N-nucleophiles delivered three classes (external salts, inner salts, and neutral azacycles) of five-membered azacycles bearing a tetrasubstituted saturated carbon center, as a result of [4+1] annulation with the alkyne being a one-carbon synthon. All the reactions proceeded under relatively mild conditions with broad substrate scope, high efficiency, and excellent regioselectivity. The synthetic applications of this protocol have also been demonstrated, and exptl. studies have been performed to support the proposed mechanism. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Application of 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Application of 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Aromatic C-H Methylation and Other Functionalizations via Rh(III)-Catalyzed Migratory Insertion of Bis(phenylsulfonyl)carbene and Subsequent Transformations was written by Chen, Lei;Peng, Rui-jun;Zhang, Xue-jing;Yan, Ming;Chan, Albert S. C.. And the article was included in Journal of Organic Chemistry in 2021.Quality Control of 2-(m-Tolyl)pyridine This article mentions the following:

A Rh(III)-catalyzed migratory insertion of bis(phenylsulfonyl)carbene into aromatic C-H bonds has been developed. A variety of bis(phenylsulfonyl)methyl derivatives e.g., I were prepared with good yields under mild conditions. The methylated products e.g., II were readily obtained after reductive desulfonylation. Furthermore, the diverse transformations of bis(phenylsulfonyl)methyl to other functional groups III (R = trideuteriomethyl, formyl, Et, etc.) were demonstrated. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Quality Control of 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Quality Control of 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Visible light-induced aerobic C-N bond activation: a photocatalytic strategy for the preparation of 2-arylpyridines and 2-arylquinolines was written by Hu, Bei;Li, Yuyuan;Dong, Wuheng;Xie, Xiaomin;Wan, Jun;Zhang, Zhaoguo. And the article was included in RSC Advances in 2016.Category: pyridine-derivatives This article mentions the following:

An efficient method for accessing arylpyridines, e.g., I and arylquinolines, e.g., II via visible light-induced aerobic C-N bond activation is described. The applicability of different kinds of simple ketones such as 1-(2-methoxyphenyl)ethanone, 1-tetralone, 1-(2-pyridinyl)ethanone, etc. easily available amines (such as, diaminopropane, 2-aminobenzylamine), and the use of air as the sole oxidant make this transformation very attractive. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Category: pyridine-derivatives).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A Novel Convenient Synthesis of Pyridinyl and Quinolinyl Triflates and Tosylates via One-Pot Diazotization of Aminopyridines and Aminoquinolines in Solution was written by Kassanova, Assiya Zh.;Krasnokutskaya, Elena A.;Beisembai, Perizat S.;Filimonov, Victor D.. And the article was included in Synthesis in 2016.Quality Control of 2-(m-Tolyl)pyridine This article mentions the following:

The first effective and simple method for the direct one-pot transformation of 2-, 3-, and 4-aminopyridines, 2,6-diaminopyridines, and 2-aminoquinoline into the corresponding pyridinyl and quinolinyl trifluoromethanesulfonates and tosylates in solvents was developed. The procedure involves diazotization of the heterocyclic amines with sodium nitrite in mixed hexane-DMSO or hexane-DMF solutions in the presence of trifluoromethanesulfonic acid or p-toluenesulfonic acid. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Quality Control of 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Quality Control of 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Facile C-H arylation using catalytically active terminal sulfurs of 2 dimensional molybdenum disulfide was written by Hwang, Eunhee;Mi Lee, Sae;Bak, Sora;Min Hwang, Hee;Kim, Hyunjung;Lee, Hyoyoung. And the article was included in Tetrahedron Letters in 2018.Application of 4373-61-9 This article mentions the following:

The first methodol. of C-H arylation of heteroarene via 2D transition metal dichalcogenides that have catalytically active edge functional groups was described. The terminal sulfur groups could effectively catalyze a formation of an azo-linked intermediate with aryl diazonium salts, leading to produce heteroarenes with good yields. This novel methodol. using bulk 2D transition metal dichalcogenides that have catalytically active edge functional groups can apply for various reactions to achieve C-C bond formation in the fields of heterogeneous catalysis that is easily separable, highly reusable, and inexpensive method. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Application of 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application of 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem