Category: 4373-61-9

Water-mediated C-H activation of arenes with secure carbene precursors: the reaction and its application was written by Nie, Ruifang;Lai, Ruizhi;Lv, Songyang;Xu, Yingying;Guo, Li;Wang, Qiantao;Wu, Yong. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.SDS of cas: 4373-61-9 This article mentions the following:

A water-mediated C-H activation using sulfoxonium ylides was reported, providing a general, green and step-economic approach to construct a C-C bond and varieties of useful N-heterocycle scaffolds. Three series of aryl-alkylketones RCOCH²R¹ [R = t-Bu, 1-adamantanyl, Ph; R¹ = 2-(2-pyridyl)phenyl, 2-(2-pyridyl)-3-thienyl, 2-pyrazol-1-ylphenyl, etc.], benzothiazines I [R² = Me, i-Pr, Ph, Bn; R³ = i-Pr, t-Bu, Ph; R⁴ = H, 6-Me, 6-OMe, 6-F, 8-OMe] and isoquinolines II [R⁵ = H, 8-F, 6-Br, etc.; R⁶ = H, Me; R⁷ = 2,6-di-MeOC₆H₃, 2-naphthyl, 2-thienyl, etc.] were synthesized via rhodium-catalyzed coupling of arenes/sulfoximines/benzylamines with sulfoxonium ylides. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9SDS of cas: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. SDS of cas: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

α-Halo carbonyls enable meta selective primary, secondary and tertiary C-H alkylations by ruthenium catalysis was written by Paterson, Andrew J.;Heron, Callum J.;McMullin, Claire L.;Mahon, Mary F.;Press, Neil J.;Frost, Christopher G.. And the article was included in Organic & Biomolecular Chemistry in 2017.Recommanded Product: 2-(m-Tolyl)pyridine This article mentions the following:

A catalytic meta selective C-H alkylation of arenes is described using a wide range of α-halo carbonyls as coupling partners. Previously unreported primary alkylations with high meta selectivity have been enabled by this methodol. whereas using straight chain alkyl halides affords ortho substituted products. Mechanistic anal. reveals an activation pathway whereby cyclometalation with a ruthenium(II) complex activates the substrate mol. and is responsible for the meta selectivity observed A distinct second activation of the coupling partner allows site selective reaction between both components. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Recommanded Product: 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Palladium-Catalyzed Decarbonylative Cross-Coupling of Azinecarboxylates with Arylboronic Acids was written by Muto, Kei;Hatakeyama, Taito;Itami, Kenichiro;Yamaguchi, Junichiro. And the article was included in Organic Letters in 2016.Application In Synthesis of 2-(m-Tolyl)pyridine This article mentions the following:

The first palladium-catalyzed decarbonylative coupling of Ph 2-azinecarboxylates and arylboronic acids is presented. The key for the development of this decarbonylative coupling is the use of Pd/dcype as a catalyst. A wide range of 2-azinecarboxylates can undergo the present coupling reaction to afford 2-arylazines. By combination with previously reported nickel-catalyzed decarbonylative coupling, we achieved a chemoselective sequential decarbonylative coupling of pyridinedicarboxylate to synthesize 2,4-diarylpyridine. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Application In Synthesis of 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Application In Synthesis of 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pd-Catalyzed Directed Thiocyanation Reaction by C-H Bond Activation was written by Gao, Melissa;Chen, Mu-Yi;Pannecoucke, Xavier;Jubault, Philippe;Besset, Tatiana. And the article was included in Chemistry – A European Journal in 2020.Name: 2-(m-Tolyl)pyridine This article mentions the following:

The Pd-catalyzed directed thiocyanation reaction of arenes and heteroarenes by C-H bond activation was achieved. In the presence of an electrophilic SCN source, this original methodol. offered an efficient tool to access a panel of functionalized thiocyanated compounds I (R = H, 2-F, 4-OMe, etc.; DG = pyridin-2-yl, pyrimidin-2-yl, pyrazol-1-yl) (21 examples, up to 78% yield). Post-functionalization reactions further demonstrated the synthetic utility of the approach by converting the SCN-containing mols. into value-added scaffolds. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Name: 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Name: 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

2,2′-Homocoupled Azine N,N’-Dioxides or Azine N-Oxides: CDC- or S_NAr-Controlled Chemoselectivity was written by Jha, Abadh Kishor;Jain, Nidhi. And the article was included in European Journal of Organic Chemistry in 2017.Name: 2-(m-Tolyl)pyridine This article mentions the following:

An unprecedented Cu(OAc)₂– and LiOtBu-mediated homocoupling of azine N-oxides to yield 2,2′-azine N,N’-dioxides is reported. This is the first instance in which copper was used to catalyze the homodimerization reaction, especially of 2-phenylpyridine N-oxides. In the absence of catalytic copper, the reaction follows an alternative pathway, and instead of dioxides it yields 2,2′-azine N-monoxides. This latter protocol works efficiently with a range of N-heterocyclic oxides of pyridine, 2-phenylpyridine, quinoline and N-aryl-1,2,3-triazole. It is scalable, offers high regioselectivity and gives the products in moderate to high yields. The observed chemoselectivity between the copper-assisted and copper-free protocols is routed through oxidative cross-dehydrogenative coupling (CDC) and nucleophilic aromatic substitution of hydrogen (S_NAr) pathways, resp. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Name: 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Name: 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem