Category: 4487-59-6

Reference of 4487-59-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4487-59-6, name is 2-Bromo-5-nitropyridine, molecular formula is C5H3BrN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 2-bromo-5-nitropyridine (12.0 g, 59.1 mmol, CAS No.: 4487-59-6) and copper (I) cyanide (7.94 g, 88.7 mmol) in N,N-dimethylformamide (50 mL) was heated under reflux for 16 hours. After being cooled down to room temperature, the reaction mixture was poured into water and then extracted with ethyl acetate (100 mL x 3). The combined organiclayer was washed with brine, and then dried over sodium sulfate and filtered. The filtrate was concentrated in vacuo to afford 8.0 g of 5-nitropyridine-2-carbonitrile (yield was 90.8%).

According to the analysis of related databases, 4487-59-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; WANG, Lisha; YUN, Hongying; ZHANG, Weixing; ZHENG, Xiufang; WO2015/22301; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 4487-59-6, 2-Bromo-5-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2-Bromo-5-nitropyridine, blongs to pyridine-derivatives compound. name: 2-Bromo-5-nitropyridine

Example 3 5-Nitropyridine-2-carbonitrile, a Compound of Formula 1 in which C Comprises 5-nitropyridin-2-yl and R8 is –CN A mixture comprising 2-bromo-5-nitropyridine (5.6 g, 27.7 mmol), cuprous cyanide (2.5 g, 27.4 mmol) and DMF (5 mL) was heated at 105 C. for 2.5 hours, cooled and diluted with methylene chloride (200 mL). The mixture was stirred 20 minutes, filtered and concentrated under reduced pressure. The residue was dissolved in methylene chloride and the solution was washed sequentially with 2N sodium hydroxide (150 mL), 7M ammonium hydroxide (150 mL) and water (150 mL), dried (MgSO4), filtered and concentrated under reduced pressure to provide 5-nitropyridine-2-carbonitrile (3.14 g, 21 mmol) as a yellow oil. 1 H-NMR (300 Mhz, DMSO-d6): 8.4 (d, 1H), 8.8 (d, 1H), 9.5 (s, 1H); MS (EI); Calculated for C6 H3 N3 O2, 149.1, Found (MH+): 149.

The synthetic route of 4487-59-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Axys Pharmaceuticals, Inc.; US6150379; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4487-59-6, name is 2-Bromo-5-nitropyridine, the common compound, a new synthetic route is introduced below. SDS of cas: 4487-59-6

-Bromo-5-nitropyridine (0.3 g, 1.48 mmol) was treated with piperazine (0.64 g, 7.89 mmol) in tetrahydrofuran (4 mL) and the reaction mixture was stirred for 30 minutes. Subsequently the reaction mixture was poured onto ice-cold water (25 mL) and extracted with ethyl acetate (25 mL). The organic layer was washed with brine and evaporated to furnish the product.

The synthetic route of 4487-59-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ORCHID RESEARCH LABORATORIES LIMITED.; US2007/167413; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 4487-59-6, 2-Bromo-5-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-Bromo-5-nitropyridine, blongs to pyridine-derivatives compound. Recommanded Product: 2-Bromo-5-nitropyridine

To a stirred solution of 2-bromo-5-nitro-pyridine (2.9 g) and N-terbutyloxycarbonyl-piperazine (3.2 g) in DMF (100 mL) was added potassium carbonate (1.98 g). The mixture was heated at 80 C. during 1 hour and then concentrated. The residue was taken in CH2Cl2 and the organic phase was washed with water, dried over Na2SO4, filtered and evaporated under reduced pressure. The titled compound was obtained as a yellow solid (4.4 g). [0253] m.p.: 169 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4487-59-6, 2-Bromo-5-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; Dodic, Nerina; US2004/9988; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4487-59-6, name is 2-Bromo-5-nitropyridine. A new synthetic method of this compound is introduced below., HPLC of Formula: C5H3BrN2O2

Example 84Synthesis of 3-[6-{4-[5-(nitro)pyridin-2-yl]piperazin-l-yl}-5-phenyl-2- (trifluoromethyl)pyrimidin-4-yl]benzenesulfonamide.Step 1;Preparation of l-(5-nitropyridin-2-yl) piperazine. 2-Bromo-5-nitropyridine (0.3g, 1.48mmol) was treated with piperazine (0.64g, 7.89mmol) in tetrahydrofuran (4mL) and the reaction mixture was stirred for 30 minutes. Subsequently the reaction mixture was poured onto ice- cold water (25mL) and extracted with ethyl acetate (25mL). The organic layer was washed with brine and evaporated to furnish the product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4487-59-6, 2-Bromo-5-nitropyridine.

Reference:
Patent; ORCHID RESEARCH LABORATORIES LIMITED; WO2007/83182; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem