Category: 462-08-8

Adding a certain compound to certain chemical reactions, such as: 462-08-8, Pyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: Pyridin-3-amine, blongs to pyridine-derivatives compound. Recommanded Product: Pyridin-3-amine

To a solution of pyridin-3 -amine (2.5 g, 26.3 mmol) in anhydrous tetrahydiOfuran (80 mL) was added 1 M sodium bis(trimethylsilyl)amide in tetrahydrofuran (52.6 mL, 52.6 mmol) in a steady stream. The mixture was stirred for 30 minutes, treated dropwise with a solution of di-feri-butyl dicarbonate (5.92 g, 26.3 mmol) in anhydrous tetrahydrofuran (20 mL), stirred for 3 hours and concentrated. The residue was dissolved in ethyl acetate, washed with saturated aqueous sodium chloride, dried over anhydrous MgSCu, filtered, and concentrated by rotary evaporation. Purification by chromatography on silica eluting with 3%> methanol in dichloromethane afforded an amber semisolid. The material was dissolved in ethyl acetate, treated with decolorizing charcoal and vacuum filtered through diatomaceous earth. Concentration of the filtrate by rotary evaporation afforded the title compound as a light gold solid (4.35 g, 85%). MS (DCI+) m/z 195 (M+H)+.

The synthetic route of 462-08-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABBOTT LABORATORIES; ABBOTT GMBH & CO.KG; MARING, Clarence J.; PRATT, John K.; CARROLL, William A.; LIU, Dachun; BETEBENNER, David A.; HUTCHINSON, Douglas K.; TUFANO, Michael D.; ROCKWAY, Todd W.; SCHOEN, Uwe; PAHL, Axel; WITTE, Adreas; WO2012/87833; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 462-08-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 462-08-8, name is Pyridin-3-amine. A new synthetic method of this compound is introduced below.

To an ice-cooled solution of 3-aminopyridine (6 g, 63.8 mmol) and triethylamine (9.72 ml_, 70.2 mmol) in 124 ml. of dichloromethane under argon, was carefully added pivaloyl chloride (7.92 mL, 64.4 mmol) in 16 mL of dichloromethane. After the addition was completed, the reaction mixture was stirred at 0 0C for 15 minutes and then at room temperature for 18 hours. The mixture was washed with water, 4% aqueous sodium bicarbonate, brine, dried over sodium sulphate and the solvent removed under reduced pressure. The residue was purified by column chromatography on silica gel, using hexane/ethyl acetate (85:15) as eluent, to yield the title compound (8.5 g, 75%) as a white solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,462-08-8, Pyridin-3-amine, and friends who are interested can also refer to it.

Reference:
Patent; LABORATORIOS ALMIRALL, S.A.; WO2008/131922; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 462-08-8, name is Pyridin-3-amine. A new synthetic method of this compound is introduced below., Quality Control of Pyridin-3-amine

3-Aminopyridine (2 g) in tetrahydrofuran (20 mL) at 25 C. was treated with 1M sodium bis(trimethylsilylamide) in tetrahydrofuran (46.7 mL), stirred for 15 minutes, treated with di-tert-butyldicarbonate (5 g) in tetrahydrofuran, stirred for 24 hours, and concentrated. The concentrate was treated with 0.1M hydrochloric acid (40 mL) and ethyl acetate (40 mL), and the organic layer was separated, washed with brine, dried over anhydrous sodium sulfate, flitered, and concentrated. The concentrate was flash chromatographed on silica gel with 60:40 ethyl acetate/hexanes. 1H NMR (300 MHz, DMSO-d6) delta 8.43 (d, 1H), 8.29 (dd, 1H), 7.98 (m, 1H), 6.57 (b, 1H), 1.53 (s, 9H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 462-08-8, Pyridin-3-amine.

Reference:
Patent; Anderson, David D.; Beutel, Bruce A.; Cooper, Curt S.; Gu, Yu-Gui; Hinman, Mira M.; Kalvin, Douglas M.; Keyes, Robert F.; Searle, Xenia B.; Wagner, Rolf; US2005/159423; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 462-08-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 462-08-8, name is Pyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of pyridin-3-ylamine (20 g, 212.49 mmol, CAS RN 462-08-8) in a mixture of THF:Et2O (175 mL; 2.5:1 v/v) was added slowly a solution of pivaloyl chloride (26 mL, 212.5 mmol, CAS RN 3282-30-2) in THF (50 mL) and Et3N (44 mL, 318.7 mmol) at 0 C. and left stirring at that temperature for 1 h. After the completion of reaction, the reaction mixture was filtered, and the filtrate was evaporated in vacuo. The crude filter cake was washed with n-hexane to yield the title compound. Colorless crystalline solid (32 g, 85%). MS (ESI): m/z=179.4 [M+H]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 462-08-8, Pyridin-3-amine.

Reference:
Patent; Bissantz, Caterina; Dehmlow, Henrietta; Erickson, Shawn David; Karnachi, Prabha Saba; Kim, Kyungjin; Martin, Rainer E.; Mattei, Patrizio; Sander, Ulrike Obst; Pietranico-Cole, Sherrie Lynn; Richter, Hans; Ullmer, Christoph; US2012/232051; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

462-08-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 462-08-8, name is Pyridin-3-amine, the common compound, a new synthetic route is introduced below.

Example 28 Manufacturing t-butyl pyridin-3-ylcarbamate Into a solution obtained by dissolving 100.0 g (1.06 mol) of 3-aminopyridine in a mixed solvent of 300 ml of 2-propanol and 100 mL of water, a mixed solution of 266.7 g (1.22 mol) of di-t-butyl dicarbonate and 100 mL of 2-propanol was added dropwise over three hours. The inner temperature of the mixture during the dropwise addition was maintained to be 5 to 20C. After the dropwise addition was finished, the obtained mixture was stirred at room temperature for 3 hours, and the resultant was subjected to a concentration process under reduced pressure. To the concentration residue, 200 mL of water was added. After the resultant was further subjected to a concentration process, 200 mL of water was added to the concentration residue, and the deposited crystals were filtered. The obtained crystals were washed with 200 ml of water to obtain 234.2 g of hydrous crystals of t-butyl pyridin-3-ylcarbamate. The hydrous crystals were analyzed by gas chromatography with a result that the content of t-butyl pyridin-3-ylcarbamate was 79.5 wt%, with a yield of 90.2%.

Statistics shows that 462-08-8 is playing an increasingly important role. we look forward to future research findings about Pyridin-3-amine.

Reference:
Patent; Sumitomo Chemical Company, Limited; EP2269986; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 462-08-8 as follows., 462-08-8

To a flame-dried 500 mL round-bottom flask purged with N2 was added 3- aminopyridine (10.0 g, 105 mmol) and THF (109 mL). NaHMDS (210 mL, 1.0 M solution in THF, 210 mmol) was added dropwise over 1 h and the resulting red solution was stirred for 30 min. Di-tert-butyl dicarbonate (24.3 mL, 105 mmol) was added dropwise over 2 min. After 19 h, the dark red solution was concentrated to 100 mL and H2O (1.0 L) was added. The mixture was extracted with EtOAc (3×500 mL). The combined organic layers were washed with brine, dried (MgSO4) and concentrated to give product (19.9 g, 102 mmol, 97%) as a brown solid: 1H NMR (CDCl3, 400 MHz) 8.46 (d, J = 2.5 Hz, 1 H), 8.31 (dd, J = 4.7, 1.4 Hz, 1 H), 8.00 (d, J = 6.7 Hz, 1 H), 7.26 (dd, J = 8.4, 4.7 Hz, 1 H), 6.65-6.66 (m, 1 H) 1.55 (s, 9 H).

The chemical industry reduces the impact on the environment during synthesis 462-08-8, I believe this compound will play a more active role in future production and life.

Reference:
Patent; UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; HURYN, Donna M.; WIPF, Peter; LAPORTE, Matthew G.; (137 pag.)WO2018/209083; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

462-08-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 462-08-8, name is Pyridin-3-amine, molecular formula is C5H6N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

50.0 g (0.53 mol) of 3-aminopyridine was added to 34.9 g of 35percent hydrochloric acid and stirred to prepare an aqueous hydrochloric acid solution of 3-aminopyridine. In addition, 35.9 g (0.52 mol, 0.98 mol equivalent to 3-aminopyridine) of sodium nitrite was added to 54.0 g of water and stirred to prepare an aqueous solution of sodium nitrite. 131 g of hydrochloric acid was placed in a 500 mL four-necked brown colben and cooled to -20 ¡ã C. An aqueous hydrochloric acid solution of 3-aminopyridine and an aqueous solution of sodium nitrite were simultaneously added dropwise to hydrochloric acid in a temperature range of -20 ¡À 2 ¡ã C. over 2 hours with stirring. After completion of the dropwise addition, the mixture was further stirred for 30 minutes in a temperature range of -20 ¡À 2 ¡ã C. to obtain an aqueous solution of pyridine-3-diazonium salt650 g of dichloromethane was placed in 1000 mL four-necked brown bottle and cooled to 0 ¡ã C., and 119 g (1.86 mol) of sulfur dioxide gas was blown into the solution to dissolve. 0.9 g (0.006 mol) of copper (II) chloride dihydrate was added and cooled to -5 ¡ã C., and an aqueous solution of pyridine-3-diazonium salt was added over a period of 1 hour at a temperature range of -5 ¡À 2 ¡ã C. Was added dropwise. After completion of the dropwise addition, the mixture was further stirred for 1 minute at a temperature range of -5 ¡À 2 ¡ã C. The copper catalyst was removed by filtration while maintaining the temperature of the reaction solution at -5 ¡À 5 ¡ã C., and then the organic layer and the aqueous layer were separated. It was extracted with 195 g of dichloromethane ¡Á 3 times at a temperature of -5 ¡À 5 ¡ã C. and mixed all together to obtain 1353 g of an organic layer. GC analysis of this organic layer revealed that the concentration of pyridine-3-sulfonyl chloride was 3.76percent by mass and the yield was 54.0percent. The obtained organic layer was washed with 50 g of water while maintaining the temperature at 3 ¡À 2 ¡ã C., and then dehydrated using 20 g of magnesium sulfate at room temperature. After removing the magnesium sulfate by filtration, the filtrate was concentrated under reduced pressure (30 to 35 ¡ã C.,> 67 kPa) to remove dichloromethane. Subsequently, distillation under reduced pressure (110 ¡ã C., 1.3 kPa) gave 49.0 g (0.276 mol, yield 52.1percent) of pyridine-3-sulfonyl chloride.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 462-08-8, Pyridin-3-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Tama Chemical Industry Co., Ltd.; Nobushima, Hirofumi; Kobayashi, Hitoshi; (9 pag.)JP2016/175885; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

462-08-8, Adding a certain compound to certain chemical reactions, such as: 462-08-8, Pyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 462-08-8, blongs to pyridine-derivatives compound.

To an ice-cooled solution of 3-aminopyridine (6 g, 63.8 mmol) and triethyl amine (9.72 ml_, 70.2 mmol) in 124 mL of dichloromethane under argon, was carefully added pivaloyl chloride (7.92 mL, 64.4 mmol) in 16 mL of dichloromethane. After the addition was completed, the reaction mixture was stirred at 0 0C for 15 minutes and at room temperature for 18 hours. The mixture was washed with water, aqueous 4% sodium bicarbonate, brine, dried over sodium sulphate and the solvent removed under reduced pressure. The residue was purified by column chromatography on silica flash, using hexane/ethyl acetate (85:15) as eluents, to yield the title compound (8.5 g, 75%) as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,462-08-8, its application will become more common.

Reference:
Patent; LABORATORIOS ALMIRALL, S.A.; WO2007/96072; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

462-08-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 462-08-8, name is Pyridin-3-amine, molecular formula is C5H6N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A round bottom flask was charged with Bu4NBr (2 mmol, 0.64 g), EtOH (8 mL) and 2-methylaniline (2 mmol, 0.21 g) followed by CuBr2 (3 mmol, 0.67 g). The resulted mixture was stirred at 25 ¡ãC. After the completion of the reaction (monitored by TLC), the solvent was evaporated under reduced pressure. To the residue was added ammonium hydroxide (5 mL, 25percent w/v) and water (5 mL) with stirring, and the suspension was extracted with DCM(10 mL¡Á4) The organic phase was washed with saturated brine and dried over anhydrous Na2SO4. The product 2b was obtained using flash chromatograph column eluted with PE : EA (5 : 1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 462-08-8, Pyridin-3-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhao, Hong-Yi; Yang, Xue-Yan; Lei, Hao; Xin, Minhang; Zhang, San-Qi; Synthetic Communications; vol. 49; 11; (2019); p. 1406 – 1415;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The common heterocyclic compound, 462-08-8, name is Pyridin-3-amine, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 462-08-8

In the three bottle,3-aminopyridine (20.0 g, 212.5 mmol),4-Dimethylaminopyridine (4-DMAP) (0.3 g, 2.1 mmol)And pyridine (33.6 g, 425.0 mmol) dissolved in anhydrous dichloromethane (200 mL),Pivaloyl chloride (28.2 g, 233.7 mmol) was slowly added dropwise in an ice bath.0 C reaction 2h.After the reaction was completed, the reaction solution was poured into ice water, quenched with 1N hydrochloric acid, extracted with dichloromethane (250 mL¡Á3), and the organic phase was collected and washed with saturated brine (200 mL¡Á1).The solvent was evaporated under reduced pressure to give 3-pivalamidopyridine (36.2 g).Yield 95.5%.

The synthetic route of 462-08-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guizhou University; Liu Li; Huang Zhuyan; Yue Yi; (8 pag.)CN107382839; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem