462-08-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 462-08-8, name is Pyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows.
Reference Example 69 tert-Butyl N-(3-pyridyl)carbamate Sodium bis(trimethylsilyl)amide (1.0M tetrahydrofuran solution 800 mL, 0.80M) was added to a solution of 3-aminopyridine (34.2 g, 0.36 mmol) in tetrahydrofuran (800 mL), followed by stirring for two hours. A solution of di-tert-butyl dicarbonate in tetrahydrofuran (200 mL) was added thereto and stirred for 30 minutes. Water was added, extracted with ethyl acetate, and the organic layer was washed with 1N hydrochloric acid, water and brine, dried over anhydrous magnesium sulfate and evaporated. The resulting crystals were washed with hexane, to give the title compound (55.0 g) as white crystals. 1H NMR (400 MHz, CDCl3) delta1.52 (s, 9H), 6.85 (br s, 1H), 7.24 (ddd, J=8.4 Hz, 4.8 Hz, 0.8 Hz, 1H), 7.95-8.04 (m, 1H), 8. 28 (dd, J=4.8 Hz, 1.6 Hz, 1H), 8.35 (dd, J=2.8 Hz, 0.8 Hz, 1H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 462-08-8, Pyridin-3-amine.
Reference:
Patent; Hibi, Shigeki; Hoshino, Yorihisa; Yoshiuchi, Tatsuya; Shin, Kogyoku; Kikuchi, Kouichi; Soejima, Motohiro; Tabata, Mutsuko; Takahashi, Yoshinori; Shibata, Hisashi; Hida, Takayuki; Hirakawa, Tetsuya; Ino, Mitsuhiro; US2003/78277; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem