Category: 4783-68-0

Impregnated copper on magnetite as catalyst for the O-arylation of phenols with aryl halides was written by Zhang, Ying-Peng;Shi, Ai-Hong;Yang, Yun-Shang;Li, Chun-Lei. And the article was included in Chinese Chemical Letters in 2014.HPLC of Formula: 4783-68-0 This article mentions the following:

Nanoparticle Fe₃O₄ encapsulated CuO, as a heterogeneous catalyst, is a facile system for the synthesis of diaryl ethers by the cross-coupling reaction of aryl halides with phenols, which avoids expensive ligands and can be recovered from the reaction mixture by using a simple magnet. Moreover, this catalyst can be reused 3 times with high catalytic activity. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0HPLC of Formula: 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. HPLC of Formula: 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nickel-catalyzed reductive amidation of aryl-triazine ethers was written by Heravi, Majid M.;Panahi, Farhad;Iranpoor, Nasser. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Synthetic Route of C11H9NO This article mentions the following:

The reaction of activated phenolic compounds, 2,4,6-triaryloxy-1,3,5-triazine (aryl-triazine ethers), with various isocyanates or carbodiimides in the presence of a nickel pre-catalyst resulted in the synthesis of aryl amides in good to excellent yields. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Synthetic Route of C11H9NO).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Synthetic Route of C11H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ruthenium-Catalyzed meta-C_Ar-H Bond Difluoroalkylation of 2-Phenoxypyridines was written by Jia, Chunqi;Wang, Shichong;Lv, Xulu;Li, Gang;Zhong, Lei;Zou, Lei;Cui, Xiuling. And the article was included in European Journal of Organic Chemistry in 2020.SDS of cas: 4783-68-0 This article mentions the following:

A ruthenium-catalyzed meta-selective C_Ar-H bond difluoroalkylation of 2-phenoxypyridine using 2-bromo-2,2-difluoroacetate has been developed. Mechanistic studies indicated that this difluoroalkylation might involve a radical process. Furthermore, a new method is reported for the synthesis of 2-(meta-difluoroalkylphenoxy)pyridine derivatives, which are present in many pharmaceuticals and other functional compounds In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0SDS of cas: 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.SDS of cas: 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nickel-Catalyzed Suzuki-Miyaura Coupling of Heteroaryl Ethers with Arylboronic Acids was written by Li, Xiao-Jian;Zhang, Jin-Ling;Geng, Yu;Jin, Zhong. And the article was included in Journal of Organic Chemistry in 2013.Quality Control of 2-Phenoxypyridine This article mentions the following:

Nickel-catalyzed Suzuki-Miyaura coupling of heteroaryl ethers with arylboronic acids was described. Selective activation of the phenol C-O bonds was achieved by converting them into the corresponding aryl 2,4-dimethoxy-1,3,5-triazin-6-yl ethers, in which the aryl C-O bond could be selectively cleaved with inexpensive, air-stable NiCl₂(dppf) as a catalyst. Coupling of these readily accessible heteroaryl ethers proved tolerant of extensive functional groups. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Quality Control of 2-Phenoxypyridine).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Quality Control of 2-Phenoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rh(III)-Catalyzed Direct ortho-Chalcogenation of Phenols and Anilines was written by Yang, Shiping;Feng, Boya;Yang, Yudong. And the article was included in Journal of Organic Chemistry in 2017.Formula: C11H9NO This article mentions the following:

Aryl pyridinyl ethers and amines such as I (R = H; X = O, NH) underwent chemoselective and regioselective directed monosulfenylation with disulfides R¹SSR¹ (R¹ = 4-MeC₆H₄, Ph, 4-MeOC₆H₄, 2-MeOC₆H₄, 4-ClC₆H₄, 4-BrC₆H₄, 2-BrC₆H₄, 2,4-Cl₂C₆H₃, 2-naphthyl, PhCH₂) and di-Me disulfide in the presence of (Cp^*RhCl₂)₂ and AgOTf mediated by Ag₂CO₃ under air to yield pyridinyloxy- and pyridinylamino-substituted aryl thioethers such as I (R = R¹S; R¹ = 4-MeC₆H₄, Ph, 4-MeOC₆H₄, 2-MeOC₆H₄, 4-ClC₆H₄, 4-BrC₆H₄, 2-BrC₆H₄, 2,4-Cl₂C₆H₃, 2-naphthyl, PhCH₂, Me; X = O, NH) in 42-99% yields. A diaryl selenide was prepared using di-Ph diselenide,. The pyridinyl moiety was cleavage with Me triflate and either sodium methoxy or hydrazine hydrate to yield phenols and aryl amines. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Formula: C11H9NO).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Formula: C11H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rationalizations among heterocyclic partition coefficients. Part 2: The azines was written by Lewis, Susan J.;Mirrlees, Margaret S.;Taylor, Peter J.. And the article was included in Quantitative Structure-Activity Relationships in 1983.Recommanded Product: 4783-68-0 This article mentions the following:

π-Values (partition substituent constants) of 246 azines are given and discussed in terms of Δπ, the difference in π-value from that expected for C₆H₆. It is shown that Δπ is close to zero for alkyl and most halogen groups, but for polar substituents capable of H bonding it may be as high as φ1.6. Except for peri-positions, these Δπ-values may be correlated by a set of equations specific for different types of substituent position and containing terms which sep. parameterize proton-donor and -acceptor ability. The rationale behind this treatment is justified in terms of the nature of the octanol-H₂O partitioning process and the manner in which electronic effects are expected to operate, in this context and that of the individual mol. Other topics discussed include: reasons for deviations among “irregular” substituents; the special problems of peri-positions; multisubstitution; and some consequences of this anal. for other types of compound In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Recommanded Product: 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Recommanded Product: 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Diazotization and diazo reactions of 2-aminopyridine was written by Chichibabin, A. E.. And the article was included in J. Russ. Phys.-Chem. Soc. in 1920.Synthetic Route of C11H9NO This article mentions the following:

Attempts made to introduce the C₅H₅N nucleus into organic compounds by the Grignard reaction on 2-bromo- and 2-iodopyridine failed; the preparation of these substances from Na 2-pyridineisodiazoxide (C. A. 10, 2898) has been improved and is described. Successful results are, however, obtained by the interaction of the latter substance with phenol. After removing phenol, etc., 3 substances are obtained, one of which may be readily separated owing to its insolubility in alkali hydroxides. This consists of 2-phenoxypyridine, b. 277-.5°, m. 46-8°, possessing an odor reminiscent of Ph₂O; the orange chloroplatinate, m. 175-7°, and the picrate were also prepared The 2 compounds soluble in alkali are isomeric pyridylphenols, and may be separated by crystallization from C₆H₆. The less soluble compound seps. in white leaflets or thick, lustrous, hexagonal plates containing a mol. of C₆H₆ of crystallization; after removing the latter it m. 159-60° and is readily soluble both in dilute acids and alkalies, being precipitated from the latter by CO₂. It is probably p-2-pyridylphenol. The HCl salt, m. 215-8°; the chloroplatinate, orange-yellow, m. 210-1.5° (decomposition), while the sparingly soluble picrate, m. 202-3°. The 2nd, more soluble pyridylphenol is probably o-2-pyridylphenol, and is obtained in large, greenish yellow prisms, m. 56°; it is less soluble in alc. than the preceding compound and its phenolic properties are less marked; the yellow color may perhaps be due to a quinonoid structure. The HCl salt is obtained in a hydrated form, colorless prisms, m. 56°, which lose water in a desiccator, the anhydrous substance m. 167-70°. The chloroplatinate, softens at 227-8°. The picrate, yellow, m. 174°. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Synthetic Route of C11H9NO).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Synthetic Route of C11H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Palladium-Catalyzed Decarboxylative Coupling of α- Oxocarboxylic Acids with C(sp²)-H of 2-Aryloxypyridines was written by Yao, Jinzhong;Feng, Ruokun;Wu, Zaihong;Liu, Zhanxiang;Zhang, Yuhong. And the article was included in Advanced Synthesis & Catalysis in 2013.Product Details of 4783-68-0 This article mentions the following:

An efficient palladium-catalyzed decarboxylative ortho-acylation of 2-aryloxypyridines with α-oxocarboxylic acids is described. In this new transformation, the aromatic C(sp²)-H bond was successfully acylated to give diverse aromatic ketones regioselectively in moderate to good yields. The pyridine group can be removed easily after the acylation to give the corresponding 2-hydroxy aromatic ketones. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Product Details of 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Product Details of 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Scalable Rhodium(III)-Catalyzed Aryl C-H Phosphorylation Enabled by Anodic Oxidation Induced Reductive Elimination was written by Wu, Zheng-Jian;Su, Feng;Lin, Weidong;Song, Jinshuai;Wen, Ting-Bin;Zhang, Hui-Jun;Xu, Hai-Chao. And the article was included in Angewandte Chemie, International Edition in 2019.HPLC of Formula: 4783-68-0 This article mentions the following:

Transition metal catalyzed C-H phosphorylation remains an unsolved challenge. Reported methods are generally limited in scope and require stoichiometric silver salts as oxidants. Reported here is an electrochem. driven Rh^III-catalyzed aryl C-H phosphorylation reaction that proceeds through H₂ evolution, obviating the need for stoichiometric metal oxidants. The method is compatible with a variety of aryl C-H and P-H coupling partners and particularly useful for synthesizing triarylphosphine oxides from diarylphosphine oxides, which are often difficult coupling partners for transition metal catalyzed C-H phosphorylation reactions. Exptl. results suggest that the mechanism responsible for the C-P bond formation involves an oxidation-induced reductive elimination process. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0HPLC of Formula: 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.HPLC of Formula: 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ruthenium-Catalyzed ortho/meta-Selective Dual C-H Bonds Functionalizations of Arenes was written by Li, Gang;Zhu, Biao;Ma, Xingxing;Jia, Chunqi;Lv, Xulu;Wang, Junjie;Zhao, Feng;Lv, Yunhe;Yang, Suling. And the article was included in Organic Letters in 2017.Product Details of 4783-68-0 This article mentions the following:

The first example of transition-metal-catalyzed ortho/meta-selective dual C-H functionalizations of arenes in one reaction is described. In this transformation, ortho-C-H chlorination and meta-C-H sulfonation of 2-phenoxypyri(mi)dines were achieved simultaneously under catalysis by [Ru(p-cymene)Cl₂]₂. The other reactant, namely, an arylsulfonyl chloride, played the role of both a sulfonation and chlorination reagent. More importantly, the arylsulfonyl chloride was also an oxidant in the process. Mechanistic studies indicated that six-membered ruthenacycles were the key intermediate in the reaction. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Product Details of 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Product Details of 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem