Category: 483324-01-2

Adding a certain compound to certain chemical reactions, such as: 483324-01-2, 2-Chloro-4-(pyridin-3-yl)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C9H6ClN3, blongs to pyridine-derivatives compound. Formula: C9H6ClN3

Preparation of 4-pyridin-3-yl-pyrimidin-2-ylamine lll-b In a sealed tube, a solution of lll-a (1 .18 g, 6.16 mmol) in 30percent NH4OH (12 mL) was heated at deltaOmicron ‘ for 16h. After cooling, the precipitate was isolated by filtration, washed with water and dried under vacuum to give the title compound lll-b as a beige solid (925 mg, 87 percent). H NMR (400 MHz, DMSO-d6) delta 9.23 (d, J = 2.1 Hz, 1 H), 8.69 (dd, J = 4.7, 1 .3 Hz, 1 H), 8.43 – 8.38 (m, 1 H), 8.36 (d, J = 5.1 Hz, 1 H), 7.53 (dd, J = 8.0, 4.8 Hz, 1 H), 7.21 (d, J = 5.1 Hz, 1 H), 6.76 (s, 2H).

The synthetic route of 483324-01-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AB SCIENCE; MOUSSY, Alain; BENJAHAD, Abdellah; SCHALON, Claire; PEZ, Didier; CHEVENIER, Emmanuel; SANDRINELLI, Franck; MARTIN, Jason; PICOUL, Willy; WO2014/202763; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 483324-01-2 , The common heterocyclic compound, 483324-01-2, name is 2-Chloro-4-(pyridin-3-yl)pyrimidine, molecular formula is C9H6ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A 250 ml reactor, equipped with a mechanical stirrer and a reflux condenser, was charged with 2-chloro-4-(3-pyridyl)-pyrimidine (0.5 g, 2.6 mmol), 2-amino-4-nitrotoluene (0.5 g, 3.2 mmol), n-butanol (15 ml) and concentrated HCl (5 drops) and the mixture was refluxed for 38 hours. Then, the mixture was cooled, and 6 N NaOH was added to pH 8. The solvent was evaporated under reduced pressure and water (20 ml) was added to the residue, followed by extraction with dichloromethane (2×20 ml). The combined organic phase was concentrated to dryness to give the crude N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-pyrimidine-amine, which was purified by column chromatography to yield a product having 80% purity. The residue was re-slurried twice in methanol (2×2 ml) and in water (3 ml) and dried under reduced pressure

The synthetic route of 483324-01-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Anli, Huang; Xing, Liu; Zelikovitch, Lior; Kaspi, Joseph; US2006/149061; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem