Category: 490-11-9

Reference of 490-11-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 490-11-9, name is Pyridine-3,4-dicarboxylicacid, molecular formula is C7H5NO4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

10265] WXO18-1 (40.00 g, 239.35 mmol, 1.00 eq) was dissolved in anhydrous methanol (1.00 L), then concentrated sulfuric acid (11.98 g, 119.67 mmol, 6.51 mE, 98% purity, 0.50 eq) was added at 85 C. The mixture was stirred under nitrogen condition for 40 h. After reaction, the reaction liquid was concentrated under vacuum, then the concentrated solution was slowly added to saturated sodium bicarbonate solution (1,500 mE). The resulting mixture was stirred until there was no bubble generated, and extracted with ethyl acetate (1,000 mLx3). The organic phase was washed with saturated sodium chloride solution (800 mLx3), dried with anhydrous sodium sulfate and filtered. The filtrate was dried by rotary evaporation to obtain the brown oily compound WXO18-2. ?H NMR (400 MHz, CDC13) oe ppm: 9.06 (s, 1H), 8.82 (d, J4.90 Hz, 1H), 7.49 (d, J5.02 Hz, 1H), 3.94 (m, 6H).

According to the analysis of related databases, 490-11-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SHENZHEN SALUBRIS PHARM CO LTD.; Wu, Chengde; Yan, Jie; Xu, Wenjie; Yu, Tao; Li, Ning; Chen, Shuhui; US2018/305346; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 490-11-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 490-11-9, name is Pyridine-3,4-dicarboxylicacid. A new synthetic method of this compound is introduced below.

Pyridine-3,4-dicarboxylic acid 42.1 (20 g, 121 mmol) was dissolved in methanol (400 ml)then concentrated sulfuric acid (12.9 ml, 242 mmol) was added and the mixture was stirredat reflux for 3 days. The volatiles were removed and the liquid poured carefully into saturatedsodium carbonate. The pH was adjusted to 7 with sodium carbonate then extracted threetimes with ethyl acetate. The organic layer was dried over magnesium sulfate, filtered andevaporated to provide compound 42.2 (15.3 g, 65%) as an oil. 1H NMR (CDCI3, 300 MHz)O 3.95 (5, 6H), 7.50 (d, 1 H), 8.83 (d, 1 H), 9.06 (5, 1H). UPLC (CSH 2-50%) 0.60(196 [M+H]).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,490-11-9, Pyridine-3,4-dicarboxylicacid, and friends who are interested can also refer to it.

Reference:
Patent; THE UNIVERSITY OF SHEFFIELD; RICHARDS, Gareth; SKERRY, Timothy, M.; HARRITY, Joseph, P.A.; ZIRIMWABAGABO, Jean-Olivier; TOZER, Matthew, J.; GIBSON, Karl, Richard; PORTER, Roderick, Alan; BLANEY, Paul, Matthew; GLOSSOP, Paul, Alan; (369 pag.)WO2018/211275; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 490-11-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 490-11-9, name is Pyridine-3,4-dicarboxylicacid. A new synthetic method of this compound is introduced below.

Pyridine-3,4-dicarboxylic acid 42.1 (20 g, 121 mmol) was dissolved in methanol (400 ml)then concentrated sulfuric acid (12.9 ml, 242 mmol) was added and the mixture was stirredat reflux for 3 days. The volatiles were removed and the liquid poured carefully into saturatedsodium carbonate. The pH was adjusted to 7 with sodium carbonate then extracted threetimes with ethyl acetate. The organic layer was dried over magnesium sulfate, filtered andevaporated to provide compound 42.2 (15.3 g, 65%) as an oil. 1H NMR (CDCI3, 300 MHz)O 3.95 (5, 6H), 7.50 (d, 1 H), 8.83 (d, 1 H), 9.06 (5, 1H). UPLC (CSH 2-50%) 0.60(196 [M+H]).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,490-11-9, Pyridine-3,4-dicarboxylicacid, and friends who are interested can also refer to it.

Reference:
Patent; THE UNIVERSITY OF SHEFFIELD; RICHARDS, Gareth; SKERRY, Timothy, M.; HARRITY, Joseph, P.A.; ZIRIMWABAGABO, Jean-Olivier; TOZER, Matthew, J.; GIBSON, Karl, Richard; PORTER, Roderick, Alan; BLANEY, Paul, Matthew; GLOSSOP, Paul, Alan; (369 pag.)WO2018/211275; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 490-11-9 ,Some common heterocyclic compound, 490-11-9, molecular formula is C7H5NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of pyridine-3,4-dicarboxylic acid (10.00 g, 60.00 mmol, 1 eq) and a catalytic amount of DMAP (50 mg) in 300 mL of anhydrous MeOH was added dropwise SOCl2 (21.4 mL, 300.00 mmol, 5 eq) at 0 C. The reaction mixture was heated to reflux for 48 h, cooled to room temperature and concentrated in vacuo. The crude product was dissolved in CH2Cl2 (200 mL), and the solution was washed with saturated K2CO3 aqueous solution and water (50 mL), dried over anhydrous Na2SO4 and concentrated in vacuo to afford the title compound as pale yellow oil (8.00 g, 68.00%). The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 196.05 (M+1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 490-11-9, Pyridine-3,4-dicarboxylicacid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; Zhang, Jiancun; Zhang, Yingjun; Zhang, Weihong; Liu, Bing; Zhang, Jiquan; Liu, Jinlei; Zhang, Lu; US2014/228361; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 490-11-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.490-11-9, name is Pyridine-3,4-dicarboxylicacid, molecular formula is C7H5NO4, molecular weight is 167.12, as common compound, the synthetic route is as follows.

Pyridine-3,4-dicarboxylic acid (40g, 0.24mmol) was added to SOCl2 (400mL) and heated to reflux for 80 deg C fo 3h. the solvent was distilled off under reduced pressure, at 0 added dropwise to methanol (200 mL), and stirred for half an hour at room temperature, the solvent was distilled off under reduced pressure, the solid was dissolved with ethyl acetate (a 500 mL), washed twice with saturated NaHCO3 solution, the organic phase was dried over anhydrous sodium sulfate, filtered, and concentrated to give the title compound (41g, yield 87.8 %)

Statistics shows that 490-11-9 is playing an increasingly important role. we look forward to future research findings about Pyridine-3,4-dicarboxylicacid.

Reference:
Patent; Shandong Xuan Bamboo Pharmaceutical Technology Co., Ltd.; Wu, Yong qian; (49 pag.)CN105461714; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 490-11-9, name is Pyridine-3,4-dicarboxylicacid, the common compound, a new synthetic route is introduced below. COA of Formula: C7H5NO4

To a solution of pyridine-3,4-dicarboxylic acid (7.00 g, 41.9 mmol) and4-dimethylaminopyridine (80 mg, 0.65 mmol) in methanol (230 mL) was added thionylchloride (24.9 g, 210 mmol) at 0 C. The mixture was stirred at 0 C for 30 minutes.Reaction temperature was then raised up to reflux with constant stirring overnight.Having cooled down to room temperature, the reaction mixture was concentrated under reduced pressure to give a residue, which was re-dissolved in water (200 mL). The prepared solution was adjusted to pH 89 with saturated sodium bicarbonate aqueous solution at 0C. Then the aqueous was extracted with ethyl acetate (150 mL) for three times. The combined organic layers were washed with brine (200 mL), dried over Na2 SO4() and filtered. The filtrate was concentrated under reduced pressure to give the title compound (5.26 g, 64 % yield) as yellow oil. LC-MS (ESI): RT = 1.27 mm, mass calcd. for C9H9N04 195.1, mlz found 196.4 [M+H]. ?H NIVIR (400 1VIHz, DMSO-d6)9.02 (d, J 0.8 Hz, 1H), 8.91 (d, J 5.2 Hz, 1H), 7.70 (d, J= 5.2, 0.8 Hz, 1H), 3.87 (s,6H).

The synthetic route of 490-11-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; JOHNSON & JOHNSON (CHINA) INVESTMENT LTD.; WAN, Zhao-Kui; JIANG, Yimin; DAI, Xuedong; LIU, Qian; CHEUNG, Wing Shun; DENG, Gang; FU, Liqiang; (547 pag.)WO2019/1420; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 490-11-9, name is Pyridine-3,4-dicarboxylicacid, the common compound, a new synthetic route is introduced below. category: pyridine-derivatives

To a mixture of pyridine-3,4-dicarboxylic acid (10.00 g, 60.00 mmol, 1 eq) and a catalytic amount of DMAP (50 mg) in 300 mL of anhydrous MeOH was added dropwise SOCl2 (21.4 mL, 300.00 mmol, 5 eq) at 0C. The reaction mixture was heated to reflux for 48 h, cooled to room temperature and concentrated in vacuo. The crude product was dissolved in CH2C12 (200 mL), and the solution was washed with saturated K2C03 aqueous solution and water (50 mL), dried over anhydrous Na2S04 and concentrated in vacuo to afford the title compound as pale yellow oil (8.00 g, 68.00 %). The compound was characterized by the following spectroscopic data: MS (ESI, pos. ion) m/z: 196.05 (M+1).

The synthetic route of 490-11-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Jiancun; ZHANG, Yingjun; ZHANG, Weihong; LIU, Bing; ZHANG, Jiquan; LIU, Jinlei; ZHANG, Lu; WO2013/71697; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem