Category: 4926-28-7

4926-28-7 , The common heterocyclic compound, 4926-28-7, name is 2-Bromo-4-methylpyridine, molecular formula is C6H6BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 2-bromo-4-methylpyridine (1 g, 5.81mmol), NBS (1.1 g, 6.39 mmol) and a catalytic amount of AIBN (100 mg) in CCL (10 mL) was stirred at 80 C overnight. The resulting mixture was concentrated under reduced pressure and the residue was purified by column chromatography on silica gel (eluent: PE/EtOAc = 200/1) to give the desired product (500 mg).

According to the analysis of related databases, 4926-28-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; CIANCHETTA, Giovanni; LIU, Tao; PADYANA, Anil, Kumar; SUI, Zhihua; CAI, Zhenwei; CUI, Dawei; JI, Jingjing; (294 pag.)WO2019/35863; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

4926-28-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4926-28-7, name is 2-Bromo-4-methylpyridine, molecular formula is C6H6BrN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 20; Synthesis of 2-bromoisonicotinic acid; [0119] 2-Bromo-4-methylpyridine (10 g, 0.058 moles) and potassium permanganate (18.3 g, 0.115 moles) was combined in water (500 ml). The mixture was refluxed for five hours, filtered through celite and reduced in volume to-400 ml. The dark brown solution was acidified with hydrochloric acid (10%) to pH-3. The resulting white precipitate was filtered and rinsed with ethyl ether. 2-Bromoisonicotinic acid was isolated in 34 % yield. 1H NMR (DMSO-d6) 7.8 (1H, d), 7.85 (1H, s), 8.5 (1H, d).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4926-28-7, 2-Bromo-4-methylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DOV PHARMACEUTICAL, INC.; WO2005/84439; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

4926-28-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4926-28-7, name is 2-Bromo-4-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

To 1.84 g ( 1 1.6 mmol) of KMn04 in 10 mL of H20 was added 0.65 mL (5.8 mmol) of 2-bromo-4-methylpyridine via syringe. The solution was refluxed for 1 hr, after which 1.25 equivalents ( 1.15 g; 7.25 mmol) of KMn04 was added. After an additional 2 hr reflux, 1.25 equivalents of KMn04 was added and stirred overnight to produce a dark solution containing a black suspension. After filtration through celite, the clear aqueous layer was washed with 3 x 20 mL of ethyl acetate. The aqueous layer was brought to a pH of 4 using 1M HC1 to precipitate out 237 mg of a white solid (yield = 20.3%). ESI-MS: m/z, 199.7 (calcd for M+ 199.9) NMR (DMSO-d6): delta 7.84 (dd, 1H, J = 5 Hz, l = lHz), 7.96 (s, 1H), 8.59 (d, 1H, J = 5 Hz), 14.02 (vbr, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4926-28-7, 2-Bromo-4-methylpyridine.

Reference:
Patent; BERLINGUETTE, Curtis P.; KOIVISTO, Bryan; ROBSON, Kiyoshi; WO2011/32269; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem