Category: 500-22-1

An article A Simple, Mild and General Oxidation of Alcohols to Aldehydes or Ketones by SO2F2/K2CO3 Using DMSO as Solvent and Oxidant WOS:000471326000006 published article about SULFOXIDE-CARBODIIMIDE REACTIONS; DIMETHYL-SULFOXIDE; SWERN OXIDATION; TRIFLUOROACETIC-ANHYDRIDE; CATALYTIC-OXIDATION; AEROBIC OXIDATION; SELECTIVE METHOD; PHENOLS; DIMETHYLSULFOXIDE; CONVERSION in [Zha, Gao-Feng; Fang, Wan-Yin; Leng, Jing; Qin, Hua-Li] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, 205 Luoshi Rd, Wuhan 430070, Hubei, Peoples R China in 2019.0, Cited 67.0. Category: pyridine-derivatives. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A practical, general and mild oxidation of primary and secondary alcohols to carbonyl compounds proceeds in yields of up to 99% using SO2F2 as electrophile in DMSO as both the oxidant and the solvent at ambient temperature. No moisture- and oxygen-free conditions are required. Stoichiometric amount of inexpensive K2CO3, which generates easy to separate by-products, is used as the base. Thus, 5-gram scale runs proceeded in nearly quantitative yields by a simple filtration as the work-up. The use of a polar solvent such as DMSO, which usually promotes competing Pummerer rearrangement, is also noteworthy. This protocol is compatible with a variety of common N-, O-, and S-functional groups on (hetero)arene, alkene and alkyne substrates (68 examples). The protocol was applied (99% yield) to a formal synthesis of the important cholesterol-lowering drug Rosuvastatin.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Zha, GF; Fang, WY; Leng, J; Qin, HL or concate me.. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Metal-free nitrogen -doped carbon nanosheets: a catalyst for the direct synthesis of imines under mild conditions WOS:000468627300030 published article about ORDERED MESOPOROUS CARBON; ONE-POT; TANDEM SYNTHESIS; OXIDATIVE SYNTHESIS; METHANOL OXIDATION; ORGANIC FRAMEWORK; AEROBIC OXIDATION; EFFICIENT; AMINES; NANOPARTICLES in [Wang, Kaizhi; Jiang, Pengbo; Yang, Ming; Ma, Ping; Qin, Jiaheng; Huang, Xiaokang; Ma, Lei; Li, Rong] Lanzhou Univ, SKLAOC, Lanzhou 730000, Gansu, Peoples R China; [Wang, Kaizhi; Jiang, Pengbo; Yang, Ming; Ma, Ping; Qin, Jiaheng; Huang, Xiaokang; Ma, Lei; Li, Rong] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China in 2019, Cited 77. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Computed Properties of C6H5NO

Herein, a highly stable, porous, multifunctional and metal-free catalyst was developed, which exhibited significant catalytic performance in the oxidation of amines and transfer hydrogenation of nitriles under mild conditions; this could be attributed to the presence of numerous active sites and their outstanding BET surface area. The obtained results showed that most of the yields of imines exceeded 90%, and the cycling performance of the catalyst could be at least seven runs without any decay in the reaction activity, which could be comparable to those of metal catalysts. Subsequently, a kinetic study has demonstrated that the apparent activation energy for the direct synthesis of imines from amines is 67.39 kJ mol(-1), which has been performed to testify that the catalytic performances are rational. Via catalyst characterizations and experimental data, graphitic-N has been proven to be the active site of the catalyst. Hence, this study is beneficial to comprehend the mechanism of action of a metal-free N-doped carbon catalyst in the formation of imines.

Computed Properties of C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Wang, KZ; Jiang, PB; Yang, M; Ma, P; Qin, JH; Huang, XK; Ma, L; Li, R or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Synthesis, Biological Evaluation and Molecular Docking Studies of Novel Coumarinylthiazolyl Iminothiazolidinone Hybrids as Potent Urease Inhibitors WOS:000532796500003 published article about COUMARIN DERIVATIVES; DESIGN in [Shams-Ul Mahmood; Saeed, Aamer] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan; [Nazir, Yasir; Ashraf, Zaman] Allama Iqbal Open Univ, Dept Chem, Islamabad 44000, Pakistan; [Abbas, Qamar] Univ Sindh, Dept Physiol, Jamshoro, Pakistan in 2020.0, Cited 26.0. Safety of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

The present paper is designed to explore the potential of an important class of heterocycles coumarinylthiazolyl iminothiazolidinone to inhibit jack bean urease. The final products 6a-j were prepared by condensation of substituted aldehydes with intermediate 5 in sodium methoxide/methanol mixture. The synthesized compounds were characterized by their FTIR, H-1, C-13 NMR and mass spectral data. The synthesized coumarinylthiazolyl iminothiazolidinone hybrids 6 a-j were evaluated for their potential to inhibit urease activity. All the synthesized derivatives showed remarkable inhibitory activity with IC50 ranging 8 to 34 nM, while IC50 of standard thiourea is 18.5 nM. The compound 5-(2,4-Dichlorobenzylidene)-2-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl imino) thiazolidin-4-one 6 h bearing 2,4-di-chloro substituted phenyl ring exhibited excellent activity with IC50 value 8 nM. In silico molecular docking studies was performed against urease enzyme PDBID 4H9 M and predicted possible binding modes in catalytic site for these active compounds. The thiazole nitrogen in compound 6 h formed a strong hydrogen bonding interaction with side chain Gln635 having distance 2.01 angstrom and rest part of this inhibitor is present close to Val640. The most potent derivative 6 h have highest binding affinity with binding energy -6.178 kcal/mol. It is concluded based upon our results that 6 a and 6 h are most promising compounds from this series and provide a basis for rationale design of most potent urease inhibitors.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Shams-Ul Mahmood; Nazir, Y; Saeed, A; Abbas, Q; Ashraf, Z or concate me.. Safety of 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Silver-Promoted Direct Phosphorylation of Bulky C(sp(2))-H Bond to Build Fully Substituted beta-Phosphonodehydroamino Acids WOS:000563755700039 published article about POLO-BOX DOMAIN; ALPHA-AMINO; PD(II)-CATALYZED PHOSPHORYLATION; DEHYDROAMINO ACIDS; MICHAEL ADDITION; C BOND; ROUTE; ACCESS; DEHYDROTRYPTOPHAN; PHOSPHONATION in [Cao, Hao-Qiang; Liu, Hao-Nan; Liu, Zhe-Yuan; Qiao, Baokun; Zhang, Fa-Guang; Ma, Jun-An] Tianjin Univ, Dept Chem, Tianjin Key Lab Mol Optoelect Sci, Frontiers Sci Ctr Synthet Biol,Minist Educ, Tianjin 350072, Peoples R China; [Cao, Hao-Qiang; Liu, Hao-Nan; Liu, Zhe-Yuan; Qiao, Baokun; Zhang, Fa-Guang; Ma, Jun-An] Tianjin Univ, Tianjin Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 350072, Peoples R China; [Cao, Hao-Qiang; Liu, Hao-Nan; Liu, Zhe-Yuan; Qiao, Baokun; Zhang, Fa-Guang; Ma, Jun-An] Tianjin Univ, Joint Sch Natl Univ Singapore & Tianjin Univ, Int Campus, Fuzhou 350207, Peoples R China in 2020.0, Cited 55.0. Quality Control of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A general and practical cross-dehydrogenative coupling protocol between readily available trisubstituted alpha,beta-dehydro alpha-amino carboxylic esters and H-phosphites is described. This C(sp(2))-H phosphorylation reaction proceeds with absolute Z-selectivity promoted by silver salt in a radical relay manner. The bulky tetrasubstituted beta-phosphonodehydroamino acids were obtained in grams and added new modules to the toolkit for peptide modifications.

Quality Control of 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Cao, HQ; Liu, HN; Liu, ZY; Qiao, BK; Zhang, FG; Ma, JA or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Name: 3-Pyridinecarboxaldehyde. I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Synthesis and evaluation of the performance of a small molecule library based on diverse tropane-related scaffolds published in 2020.0, Reprint Addresses Nelson, A; Marsden, SP (corresponding author), Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

A unified synthetic approach was developed that enabled the synthesis of diverse tropane-related scaffolds. The key intermediates that were exploited were cycloadducts formed by reaction between 3-hydroxy-pyridinium salts and vinyl sulfones or sulfonamides. The diverse tropane-related scaffolds were formed by addition of substituents to, cyclisation reactions of, and fusion of additional ring(s) to the key bicyclic intermediates. A set of 53 screening compounds was designed, synthesised and evaluated in order to determine the biological relevance of the scaffolds accessible using the synthetic approach. Two inhibitors of Hedgehog signalling, and four compounds with weak activity against the parasite P. falciparum, were discovered. Three of the active compounds may be considered to be indotropane or pyrrotropane pseudo natural products in which a tropane is fused with a fragment from another natural product class. It was concluded that the unified synthetic approach had yielded diverse scaffolds suitable for the design of performance-diverse screening libraries.

Name: 3-Pyridinecarboxaldehyde. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Lowe, RA; Taylor, D; Chibale, K; Nelson, A; Marsden, SP or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 ADV SYNTH CATAL published article about SULFOXIDE-CARBODIIMIDE REACTIONS; DIMETHYL-SULFOXIDE; SWERN OXIDATION; TRIFLUOROACETIC-ANHYDRIDE; CATALYTIC-OXIDATION; AEROBIC OXIDATION; SELECTIVE METHOD; PHENOLS; DIMETHYLSULFOXIDE; CONVERSION in [Zha, Gao-Feng; Fang, Wan-Yin; Leng, Jing; Qin, Hua-Li] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, 205 Luoshi Rd, Wuhan 430070, Hubei, Peoples R China in 2019.0, Cited 67.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Product Details of 500-22-1

A practical, general and mild oxidation of primary and secondary alcohols to carbonyl compounds proceeds in yields of up to 99% using SO2F2 as electrophile in DMSO as both the oxidant and the solvent at ambient temperature. No moisture- and oxygen-free conditions are required. Stoichiometric amount of inexpensive K2CO3, which generates easy to separate by-products, is used as the base. Thus, 5-gram scale runs proceeded in nearly quantitative yields by a simple filtration as the work-up. The use of a polar solvent such as DMSO, which usually promotes competing Pummerer rearrangement, is also noteworthy. This protocol is compatible with a variety of common N-, O-, and S-functional groups on (hetero)arene, alkene and alkyne substrates (68 examples). The protocol was applied (99% yield) to a formal synthesis of the important cholesterol-lowering drug Rosuvastatin.

Product Details of 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Zha, GF; Fang, WY; Leng, J; Qin, HL or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 BIOORGAN MED CHEM published article about GABA UPTAKE INHIBITORS; HIGH-AFFINITY; BRAIN; PHARMACOLOGY; MECHANISMS; NNC-711; MARKER; LIVER in [Kern, Felix; Wanner, Klaus T.] Ludwig Maximilians Univ Munchen, Ctr Drug Res, Dept Pharm, Butenandtstr 7, D-81377 Munich, Germany; [Kern, Felix] Wielandstr 13, D-65187 Wiesbaden, Germany in 2019.0, Cited 41.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. SDS of cas: 500-22-1

Generation and screening of oxime libraries by competitive MS Binding Assays represents a powerful tool for the identification of new compounds, with affinity to mGAT1, the most abundant plasma membrane bound GABA transporter in the CNS. By screening a guvacine derived oxime library, new potent inhibitors of mGAT1 had been revealed. In the present study, oxime libraries generated by reaction of a large excess of a rac-nipecotic acid derivative displaying a hydroxylamine functionality in which various aldehydes under suitable conditions, were examined for new potent inhibitors of mGAT1. The pK(i) values obtained of the best hits were compared with those of related compounds displaying a guvacine instead of a nipecotic acid subunit as hydrophilic moiety. Amongst the new compounds one of the most affine ligands of mGAT1 known so far (pK(i)= 8.55 +/- 0.04) was found.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Kern, F; Wanner, KT or concate me.. SDS of cas: 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about TRANSITION-STATE ANALOG; CRYSTAL-STRUCTURE; HYDROXY COMPOUNDS; DERIVATIVES; PYRROLIDINE; BINDING; PHOSPHORYLATION; ENANTIOMERS; MECHANISM; ALCOHOLS, Saw an article supported by the Royal SocietyRoyal Society of LondonEuropean Commission; EPSRCUK Research & Innovation (UKRI)Engineering & Physical Sciences Research Council (EPSRC) [EP/I000992/1]; University of Surrey, U.K.; Sultanate of Oman; Erasmus+ scheme. Formula: C6H5NO. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Claret, EM; Al Yahyaei, B; Chu, SY; Elliott, RM; Imperato, M; Lopez, A; Meira, LB; Howlin, BJ; Whelligan, DK. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

The DNA repair enzyme AAG has been shown in mice to promote tissue necrosis in response to ischaemic reperfusion or treatment with alkylating agents. A chemical probe inhibitor is required for investigations of the biological mechanism causing this phenomenon and as a lead for drugs that are potentially protective against tissue damage from organ failure and transplantation, and alkylative chemotherapy. Herein, we describe the rationale behind the choice of arylmethylpyrrolidines as appropriate aza-nucleoside mimics for an inhibitor followed by their synthesis and the first use of a microplate-based assay for quantification of their inhibition of AAG. We finally report the discovery of an imidazol-4-ylmethylpyrrolidine as a fragment-sized, weak inhibitor of AAG.

Formula: C6H5NO. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Claret, EM; Al Yahyaei, B; Chu, SY; Elliott, RM; Imperato, M; Lopez, A; Meira, LB; Howlin, BJ; Whelligan, DK or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Application of 500-22-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 500-22-1 as follows.

General procedure: In a round-bottomed flask equipped with a condenser and a magnetic stirrer, a mixture of aldehyde (1 mmol), 1,2-phenylenediamine (1 mmol) and Cu(II)-TDnSiO2 (10 mg, containing 0.0034 mmol Cu(II)) in EtOAc (2 mL) was stirred at 50 C. The progress of the reaction was monitored by TLC (eluent: n-hexane/EtOAc, 2:1). After completion of the reaction, the mixture was cooled to room temperature and EtOAc/EtOH (3:2, 15 mL) was added. The catalyst was separated by filtration and washed with EtOAc (10 mL). The filtrate was evaporated and the crude product was purified by recrystallization from EtOAc or EtOH to afford the pure product

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,500-22-1, its application will become more common.

Reference:
Article; Nasr-Esfahani, Mahboobeh; Mohammadpoor-Baltork, Iraj; Khosropour, Ahmad Reza; Moghadam, Majid; Mirkhani, Valiollah; Tangestaninejad, Shahram; Journal of Molecular Catalysis A: Chemical; vol. 379; (2013); p. 243 – 254;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 500-22-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 500-22-1, Name is 3-Pyridinecarboxaldehyde, SMILES is O=CC1=CC=CN=C1, belongs to pyridine-derivatives compound. In a article, author is Gaire, Sanjay, introduce new discover of the category.

1,3-Bis(pyridineylidene)isoindoline: an isoindoline chelate with a stretched electronic structure

A bridging carbon analog of the well-studied bis(pyridyl)iminoisoindoline (BPI) can be produced via a one step reaction between diiminoisoindoline and pyridine-2-acetonitrile. The resultant bis(pyridineylidene)isoindoline (BPYI) is structurally analogous to BPI and can readily form metal complexes. However, it exhibits a markedly different electronic structure with intense absorption bands in the visible region of the spectrum.

Reference of 500-22-1, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 500-22-1.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem