Category: 500-22-1

Wang, ZZ; Song, T; Yang, Y in [Wang, Zhaozhan; Song, Tao; Yang, Yong] Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Key CAS Lab Biobased Mat, Qingdao 266101, Shandong, Peoples R China published Additive- and Oxidant-Free Expedient Synthesis of Benzimidazoles Catalyzed by Cobalt Nanocomposites on N-Doped Carbon in 2019.0, Cited 47.0. Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

A one-pot direct synthesis of a wide range of biologically active benzimidazoles through coupling of phenylenediamines and aldehydes catalyzed by a highly recyclable nonnoble cobalt nanocomposite was developed. A broad set of benzimidazoles can be efficiently synthesized in high yields and with good functional-group tolerance under additive- and oxidant-free mild conditions. The catalyst can be easily recycled for successive uses, and the process permits gram-scale syntheses of benzimidazoles.

Welcome to talk about 500-22-1, If you have any questions, you can contact Wang, ZZ; Song, T; Yang, Y or send Email.. Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Sapijanskaite-Banevic, B; Sovkovaja, B; Vaickelioniene, R; Siugzdaite, J; Mickeviciute, E in [Sapijanskaite-Banevic, Birute; Sovkovaja, Bozena; Vaickelioniene, Rita] Kaunas Univ Technol, Dept Organ Chem, Radvilenu Rd 19, LT-50254 Kaunas, Lithuania; [Siugzdaite, Jurate] Lithuanian Univ Hlth Sci, Dept Vet Pathobiol, Vet Acad, Tilzes Str 18, LT-47181 Kaunas, Lithuania; [Mickeviciute, Egle] Kaunas Univ Technol, Dept Informat Syst, Studentu Str 50, LT-51368 Kaunas, Lithuania published Synthesis, Characterization and Bioassay of Novel Substituted 1-(3-(1,3-Thiazol-2-yl)phenyl)-5-oxopyrrolidines in 2020.0, Cited 52.0. Computed Properties of C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Thiazole derivatives attract the attention of scientists both in the field of organic synthesis and bioactivity research due to their high biological activity. In the present study, thiazole ring was obtained by the interaction of 1-(4-(bromoacetyl)phenyl)-5-oxopyrrolidine-3-carboxylic acid with thiocarbamide or benzenecarbothioamide, as well as tioureido acid. A series of substituted 1-(3-(1,3-thiazol-2-yl)phenyl)-5-oxopyrrolidines with pyrrolidinone, thiazole, pyrrole, 1,2,4-triazole, oxadiazole and benzimidazole heterocyclic fragments were synthesized and their antibacterial properties were evaluated against Gram-positive strains of Staphylococcus aureus, Bacillus cereus, Listeria monocytogenes and Gram-negative Pseudomonas aeruginosa, Escherichia coli and Salmonella enterica enteritidis. The vast majority of compounds exhibited between twofold and 16-fold increased antibacterial effect against the test-cultures when compared with Oxytetracycline.

Computed Properties of C6H5NO. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Catalyst-Free Synthesis of Chromane-Type N,O-Acetals via Intramolecular Addition of Phenols to Enamines WOS:000583039100009 published article about ORTHO-QUINONE METHIDES; ANTITUMOR AGENTS; DERIVATIVES; PRECURSORS; NUCLEOPHILES; ALKYLATION; ANALOGS in [Osyanin, Vitaly A.; Osipov, Dmitry V.; Melnikova, Irina V.; Korzhenko, Kirill S.; Semenova, Irina A.; Klimochkin, Yuri N.] Samara State Tech Univ, Dept Organ Chem, Fac Chem Technol, 244 Molodogvardeyskaya St, Samara 443100, Russia in 2020.0, Cited 54.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Quality Control of 3-Pyridinecarboxaldehyde

A new strategy to 2-aminochromanes through catalyst-free cascade reaction of 3-trifluoroacetyl-4H-chromenes and 4H-chromene-3-carbaldehydes with cyclic secondary amines is presented. The reaction proceeds through subsequent 1,4- and 1,2-additions of amine, bimolecular elimination of trifluoroacetamide or formamide, and 6-exotrig cyclization. The latter stage is a very rare example of addition of phenols to enamines. The obtained semicyclic N,O-acetals were applied as useful precursors for the synthesis of other chromanes.

Quality Control of 3-Pyridinecarboxaldehyde. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer WOS:000526982300002 published article about IN-VITRO; AGENT; MECHANISM; INSIGHTS in [Ding, Zhongpeng; Li, Feifei; Zhong, Changjiang; Liu, Yuqian; Zhao, Jianchun; Li, Wenbao] Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Peoples R China; [Li, Wenbao] Qingdao Natl Lab Marine Sci & Technol, Innovat Ctr Marine Drug Screening & Evaluat, Qingdao 266071, Peoples R China; [Li, Feng] Weifang Univ Sci & Technol, Shandong Peninsula Engn Res Ctr Comprehens Brine, Weifang 262700, Shandong, Peoples R China; [Wang, Shixiao; Zhao, Jianchun; Li, Wenbao] Marine Biomed Res Inst Qingdao, Qingdao 266071, Peoples R China in 2020.0, Cited 24.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Recommanded Product: 3-Pyridinecarboxaldehyde

Plinabulin, a synthetic analog of the marine natural product diketopiperazine phenylahistin, displayed depolymerization effects on microtubules and targeted the colchicine site, which has been moved into phase III clinical trials for the treatment of non-small cell lung cancer (NSCLC) and the prevention of chemotherapy-induced neutropenia (CIN). To develop more potent anti-microtubule and cytotoxic derivatives, the co-crystal complexes of plinabulin derivatives were summarized and analyzed. We performed further modifications of the tert-butyl moiety or C-ring of imidazole-type derivatives to build a library of molecules through the introduction of different groups for novel skeletons. Our structure-activity relationship study indicated that compounds 17o (IC50 = 14.0 nM, NCI-H460) and 17p (IC50 = 2.9 nM, NCI-H460) with furan groups exhibited potent cytotoxic activities at the nanomolar level against various human cancer cell lines. In particular, the 5-methyl or methoxymethyl substituent of furan group could replace the alkyl group of imidazole at the 5-position to maintain cytotoxic activity, contradicting previous reports that the tert-butyl moiety at the 5-position of imidazole was essential for the activity of such compounds. Immunofluorescence assay indicated that compounds 17o and 17p could efficiently inhibit microtubule polymerization. Overall, the novel furan-diketopiperazine-type derivatives could be considered as a potential scaffold for the development of anti-cancer drugs.

Welcome to talk about 500-22-1, If you have any questions, you can contact Ding, ZP; Li, FF; Zhong, CJ; Li, F; Liu, YQ; Wang, SX; Zhao, JC; Li, WB or send Email.. Recommanded Product: 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Degrasyn exhibits antibiotic activity against multi-resistant Staphylococcus aureus by modifying several essential cysteines WOS:000519216400022 published article about ACID SYNTHESIS; INHIBITORS in [Lee, Kyu Myung; Le, Philipp; Sieber, Stephan A.] Tech Univ Munich, Ctr Integrated Prot Sci, Dept Chem, Garching, Germany; [Lee, Kyu Myung; Le, Philipp; Sieber, Stephan A.] Tech Univ Munich, Chair Organ Chem 2, Garching, Germany; [Hacker, Stephan M.] Tech Univ Munich, Dept Chem, Garching, Germany in 2020.0, Cited 24.0. HPLC of Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

Degrasyn inhibits deubiquitination enzymes and has anti-cancer activity. We here show that it also exhibits antimicrobial activity against multi-resistant Staphylococcus aureus. Structure activity relationship studies demonstrate an important role of the electrophilic alpha-cyanoacrylamide moiety as a Michael acceptor. A suite of chemical proteomic techniques unraveled binding of this moiety to various cysteine residues of essential proteins in a reversibly covalent manner.

Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.. HPLC of Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Product Details of 500-22-1. I found the field of Chemistry very interesting. Saw the article Synthesis and Biological Evaluation of Heterocyclic Substituted Bis(indolyl)methanes published in 2020.0, Reprint Addresses Mao, ZW (corresponding author), Yunnan Univ Chinese Med, Coll Pharmaceut Sci, Kunming 650500, Yunnan, Peoples R China.; Wan, CP (corresponding author), Yunnan Univ Chinese Med, 1 Affiliated Hosp, Cent Lab, Kunming 650021, Yunnan, Peoples R China.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

Background: Bis(indolyl)methane derivatives are widely found in nature with a broad range of biological and pharmacological activities. The development of techniques for the synthesis and functionalization of bis(indolyl)methanes have attracted more and more attention in recent years. Objective: To study the synthesis and biological activity of heterocyclic substituted bis(indolyl)methanes. Materials and Methods: A series of heterocyclic substituted bis(indolyl)methanes (3a-3p) have been prepared by condensation reaction of indole and heterocyclic aldehydes catalyzed by boron trifluoride etherate with high yields. Preliminary in vitro anti-inflammatory in lipopolysaccharide (LIPS)-stimulated RAW-264.7 macrophages and cytotoxic activity against human tumor cell lines (A549, Hela and SGC7901) by MTT assay were tested. Results: The result indicated that heterocyclic substituted bis(indolyl)methanes showed good anti-inflammatory and selective cytotoxic activity. Especially, compounds 3o, 3p and 3q displayed similar inhibitory effect on the generation of NO to positive control dexamethasone, and compound 3q displayed similar selective cytotoxic activity to 5-FU. Conclusion: Heterocyclic substituted bis(indolyl)methanes may be used as potential anti-inflammatory and anticancer leads.

Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.. Product Details of 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Chemistry very interesting. Saw the article Highly efficient one-pot synthesis of alpha-aminophosphonates using nanoporous AlSBA-15 catalyst in a three-component system published in 2020.0. Name: 3-Pyridinecarboxaldehyde, Reprint Addresses Govindasamy, C (corresponding author), VIT Univ, Sch Adv Sci, Div Chem, Chennai 600127, Tamil Nadu, India.; Govindasamy, C (corresponding author), Imam Abdulrahman Bin Faisal Univ, IRMC, Dammam 31441, Saudi Arabia.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

Nanoporous AlSBA-15 catalysts with different nSi/nAl ratios (41, 129, and 210) were synthesized using a hydrothermal method. These catalysts were characterized by XRD, N-2 sorption, TPD-NH3, FT-IR, SEM and TEM. XRD analyses of AlSBA-15 catalysts confirmed the presence of well-ordered crystalline structure with p6mm symmetry. The specific surface area and specific pore volume of the AlSBA-15 catalysts are in the range of 480 to 757 m(2)/g and 0.65 to 0.95 cm(3)/g, respectively. The catalytic performance of nanoporous AlSBA-15 catalysts are used as an outstanding catalytic system for one-pot synthesis of alpha-aminophosphonates via Kabachnik-Fields reaction in a three-component system using amines (primary/secondary), carbonyl compounds (aldehydes/ketones) and diethyl phosphite. The major advantages of the present contributions are excellent yields, short reaction time, simple experimental technique, high chemo-selectivity, catalyst recyclability, easy work-up procedure and green approach. Three-component synthesis of alpha-aminophosphonates follows first imine formation from amine and aldehyde/ketone followed by phosphate addition. The experimental findings suggest that the nanoporous AlSBA-15 catalysts can be recycled and reused up to six cycles without any loss in the catalytic performance.

Name: 3-Pyridinecarboxaldehyde. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Cao, HQ; Liu, HN; Liu, ZY; Qiao, BK; Zhang, FG; Ma, JA in AMER CHEMICAL SOC published article about POLO-BOX DOMAIN; ALPHA-AMINO; PD(II)-CATALYZED PHOSPHORYLATION; DEHYDROAMINO ACIDS; MICHAEL ADDITION; C BOND; ROUTE; ACCESS; DEHYDROTRYPTOPHAN; PHOSPHONATION in [Cao, Hao-Qiang; Liu, Hao-Nan; Liu, Zhe-Yuan; Qiao, Baokun; Zhang, Fa-Guang; Ma, Jun-An] Tianjin Univ, Dept Chem, Tianjin Key Lab Mol Optoelect Sci, Frontiers Sci Ctr Synthet Biol,Minist Educ, Tianjin 350072, Peoples R China; [Cao, Hao-Qiang; Liu, Hao-Nan; Liu, Zhe-Yuan; Qiao, Baokun; Zhang, Fa-Guang; Ma, Jun-An] Tianjin Univ, Tianjin Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 350072, Peoples R China; [Cao, Hao-Qiang; Liu, Hao-Nan; Liu, Zhe-Yuan; Qiao, Baokun; Zhang, Fa-Guang; Ma, Jun-An] Tianjin Univ, Joint Sch Natl Univ Singapore & Tianjin Univ, Int Campus, Fuzhou 350207, Peoples R China in 2020.0, Cited 55.0. Product Details of 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A general and practical cross-dehydrogenative coupling protocol between readily available trisubstituted alpha,beta-dehydro alpha-amino carboxylic esters and H-phosphites is described. This C(sp(2))-H phosphorylation reaction proceeds with absolute Z-selectivity promoted by silver salt in a radical relay manner. The bulky tetrasubstituted beta-phosphonodehydroamino acids were obtained in grams and added new modules to the toolkit for peptide modifications.

Welcome to talk about 500-22-1, If you have any questions, you can contact Cao, HQ; Liu, HN; Liu, ZY; Qiao, BK; Zhang, FG; Ma, JA or send Email.. Product Details of 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Design, synthesis, antiviral bioactivities and interaction mechanisms of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold WOS:000462706900001 published article about BIOLOGICAL EVALUATION; 1,4-PENTADIEN-3-ONE DERIVATIVES; VIRUS; CURCUMIN; BEARING; 3D-QSAR in [Chen, Lijuan; Wang, Xiaobin; Tang, Xu; Xia, Rongjiao; Guo, Tao; Zhang, Cheng; Li, Xiangyang; Xue, Wei] Guizhou Univ, Minist Educ, Key Lab Green Pesticide & Agr Bioengn, State Key Lab Breeding Base Green Pesticide & Agr, Guiyang 550025, Guizhou, Peoples R China; [Wang, Xiaobin] Nanjing Agr Univ, Coll Sci, Nanjing 210095, Jiangsu, Peoples R China in 2019.0, Cited 39.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Application In Synthesis of 3-Pyridinecarboxaldehyde

Background: penta-1,4-diene-3-one oxime ether and quinazolin-4(3H)-one derivatives possess favorable agricultural activities. Aiming to discover novel molecules with highly-efficient agricultural activities, a series of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold were synthesized and evaluated for their antiviral activities. Result: Antiviral bioassays indicated that some title compounds exhibited significant antiviral activity against tobacco mosaic virus (TMV). In particular, compounds 8c, 8j and 8k possessed appreciable curative activities against TMV in vivo, with half-maximal effective concentration (EC50) values of 138.5, 132.9 and 125.6 mu g/mL, respectively, which are better than that of ningnanmycin (207.3 mu g/mL). Furthermore, the microscale thermophoresis experiments (MST) on the interaction of compound 8k with TMV coat protein (TMV CP) showed 8k bound to TMV CP with a dissociation constant of 0.97 mmol/L. Docking studies provided further insights into the interaction of 8k with the Arg90 of TMV CP. Conclusions: Sixteen penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold were designed, synthesized, and their antiviral activities against TMV were evaluated. Antiviral bioassays indicated that some target compounds exhibited remarkable antiviral activities against TMV. Furthermore, through the MST and docking studies, we can speculate that 8k inhibited the virulence of TMV by binding Arg90 in TMV CP. These results indicated that this kind of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold could be further studied as potential alternative templates in the search for novel antiviral agents.

Welcome to talk about 500-22-1, If you have any questions, you can contact Chen, LJ; Wang, XB; Tang, X; Xia, RJ; Guo, T; Zhang, C; Li, XY; Xue, W or send Email.. Application In Synthesis of 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

SDS of cas: 500-22-1. Riaz, S; Iqbal, M; Ullah, R; Zahra, R; Chotana, GA; Faisal, A; Saleem, RSZ in [Riaz, Sharon; Chotana, Ghayoor Abbas; Saleem, Rahman Shah Zaib] Lahore Univ Management Sci, Syed Babar Ali Sch Sci & Engn, Dept Chem & Chem Engn, Lahore 54792, Pakistan; [Iqbal, Maheen; Ullah, Rahim; Zahra, Rida; Faisal, Amir] Lahore Univ Management Sci, Syed Babar Ali Sch Sci & Engn, Dept Biol, Lahore 54792, Pakistan published Synthesis and evaluation of novel alpha-substituted chalcones with potent anti-cancer activities and ability to overcome multidrug resistance in 2019.0, Cited 45.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

A series of forty a-substituted chalcones were synthesized and screened for their antiproliferative activities against HCT116 (colorectal) and HCC1954 (breast) cancer cell lines. Compounds 5a and 5e were found to be the most potent compounds with GI(50) values of 0.63 mu M and 0.725 mu M in HCC1954 cell line and 0.69 mu M and 1.59 mu M in HCT116 cell line, respectively. Both compounds induced a G2/M cell cycle arrest and caused apoptotic cell death in HCT116 cells as shown by the induction of PARP cleavage. The compounds also stabilized p53 in a dose-dependent manner in HCT116 cells following 24-hour treatment. Furthermore, both 5a and 5e were able to overcome multidrug resistance in two MDR-1 overexpressing multidrug resistant cell lines.

SDS of cas: 500-22-1. Welcome to talk about 500-22-1, If you have any questions, you can contact Riaz, S; Iqbal, M; Ullah, R; Zahra, R; Chotana, GA; Faisal, A; Saleem, RSZ or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem