Category: 500-22-1

Safety of 3-Pyridinecarboxaldehyde. Cebeci, YU; Bayrak, H; Sirin, Y in [Cebeci, Yildiz Uygun; Sirin, Yakup] Karadeniz Tech Univ, Dept Chem, TR-61080 Trabzon, Turkey; [Bayrak, Hacer] Karadeniz Tech Univ, Dept Chem & Chem Proc Technol, TR-61080 Trabzon, Turkey published Synthesis of novel Schiff bases and azol-beta-lactam derivatives starting from morpholine and thiomorpholine and investigation of their antitubercular, antiurease activity, acethylcolinesterase inhibition effect and antioxidant capacity in 2019, Cited 30. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

In this study, new Schiff bases and beta-lactam derivatives containing morpholine and thio morpholine nuclei were synthesized. Antimicrobial, antioxidant, antimicrobial and antioxidant properties of all synthesized compounds were investigated and highly effective products were obtained. In this context, new effective structures were introduced to the literature.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Safety of 3-Pyridinecarboxaldehyde. In 2020.0 BIOORGAN MED CHEM published article about IN-VITRO; AGENT; MECHANISM; INSIGHTS in [Ding, Zhongpeng; Li, Feifei; Zhong, Changjiang; Liu, Yuqian; Zhao, Jianchun; Li, Wenbao] Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Peoples R China; [Li, Wenbao] Qingdao Natl Lab Marine Sci & Technol, Innovat Ctr Marine Drug Screening & Evaluat, Qingdao 266071, Peoples R China; [Li, Feng] Weifang Univ Sci & Technol, Shandong Peninsula Engn Res Ctr Comprehens Brine, Weifang 262700, Shandong, Peoples R China; [Wang, Shixiao; Zhao, Jianchun; Li, Wenbao] Marine Biomed Res Inst Qingdao, Qingdao 266071, Peoples R China in 2020.0, Cited 24.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Plinabulin, a synthetic analog of the marine natural product diketopiperazine phenylahistin, displayed depolymerization effects on microtubules and targeted the colchicine site, which has been moved into phase III clinical trials for the treatment of non-small cell lung cancer (NSCLC) and the prevention of chemotherapy-induced neutropenia (CIN). To develop more potent anti-microtubule and cytotoxic derivatives, the co-crystal complexes of plinabulin derivatives were summarized and analyzed. We performed further modifications of the tert-butyl moiety or C-ring of imidazole-type derivatives to build a library of molecules through the introduction of different groups for novel skeletons. Our structure-activity relationship study indicated that compounds 17o (IC50 = 14.0 nM, NCI-H460) and 17p (IC50 = 2.9 nM, NCI-H460) with furan groups exhibited potent cytotoxic activities at the nanomolar level against various human cancer cell lines. In particular, the 5-methyl or methoxymethyl substituent of furan group could replace the alkyl group of imidazole at the 5-position to maintain cytotoxic activity, contradicting previous reports that the tert-butyl moiety at the 5-position of imidazole was essential for the activity of such compounds. Immunofluorescence assay indicated that compounds 17o and 17p could efficiently inhibit microtubule polymerization. Overall, the novel furan-diketopiperazine-type derivatives could be considered as a potential scaffold for the development of anti-cancer drugs.

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Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Khazaee, A; Jahanshahi, R; Sobhani, S; Skibsted, J; Sansano, JM in [Khazaee, Asma; Jahanshahi, Roya; Sobhani, Sara] Univ Bidand, Coll Sci, Dept Chem, Birjand, Iran; [Skibsted, Jorgen] Aarhus Univ, Dept Chem, Tangelandsgade 140, DK-8000 Aarhus C, Denmark; [Skibsted, Jorgen] Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, Tangelandsgade 140, DK-8000 Aarhus C, Denmark; [Miguel Sansano, Jose] Univ Alicante, Ctr Innovac Quim Avanzada ORFEO CINQA, Fac Ciencias, Dept Quim Organ, Apdo 99, Alicante 03080, Spain; [Miguel Sansano, Jose] Univ Alicante, Inst Sintesis Organ ISO, Apdo 99, Alicante 03080, Spain published Immobilized piperazine on the surface of graphene oxide as a heterogeneous bifunctional acid-base catalyst for the multicomponent synthesis of 2-amino-3-cyano-4H-chromenes in 2020.0, Cited 103.0. Safety of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

Immobilized piperazine on the surface of graphene oxide (piperazine-GO) is synthesized and characterized by different methods such as FT-IR, solid-state(29)Si{H-1} and(13)C{H-1} CP/MAS NMR, elemental analysis, TGA, TEM, FE-SEM, XPS, and TPD. Subsequently, it is used as a heterogeneous bifunctional acid-base catalyst for the efficient multicomponent reaction of malononitrile, different active compounds containing enolizable C-H bonds and various aryl/alkyl aldehydes in aqueous ethanol. A wide variety of 2-amino-3-cyano-4H-chromenes are synthesized in the presence of this heterogeneous catalyst in good to high yields and with short reaction times. The catalyst is easily separated and reused for at least six times without significant loss of activity. The acidic nature of GO improves the catalytic activity of the supported piperazine and also provides heterogeneity to the catalyst. Use of aqueous ethanol as a green solvent, high turnover numbers (TON), facile catalyst recovery and reuse, simple work-up and generality of the method make this protocol an environmentally benign procedure for the synthesis of the title heterocycles.

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Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 BIOORGAN MED CHEM published article about GABA UPTAKE INHIBITORS; HIGH-AFFINITY; BRAIN; PHARMACOLOGY; MECHANISMS; NNC-711; MARKER; LIVER in [Kern, Felix; Wanner, Klaus T.] Ludwig Maximilians Univ Munchen, Ctr Drug Res, Dept Pharm, Butenandtstr 7, D-81377 Munich, Germany; [Kern, Felix] Wielandstr 13, D-65187 Wiesbaden, Germany in 2019.0, Cited 41.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Category: pyridine-derivatives

Generation and screening of oxime libraries by competitive MS Binding Assays represents a powerful tool for the identification of new compounds, with affinity to mGAT1, the most abundant plasma membrane bound GABA transporter in the CNS. By screening a guvacine derived oxime library, new potent inhibitors of mGAT1 had been revealed. In the present study, oxime libraries generated by reaction of a large excess of a rac-nipecotic acid derivative displaying a hydroxylamine functionality in which various aldehydes under suitable conditions, were examined for new potent inhibitors of mGAT1. The pK(i) values obtained of the best hits were compared with those of related compounds displaying a guvacine instead of a nipecotic acid subunit as hydrophilic moiety. Amongst the new compounds one of the most affine ligands of mGAT1 known so far (pK(i)= 8.55 +/- 0.04) was found.

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Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Zhou, BW; Yuan, Y; Jin, HW; Liu, YK in [Zhou, Bingwei; Yuan, Yuan; Jin, Hongwei; Liu, Yunkui] Zhejiang Univ Technol, Coll Chem Engn, State Key Lab Breeding Base Green Chem Synth Tech, Hangzhou 310014, Zhejiang, Peoples R China published I2O5-Mediated Iodocyclization Cascade of N-(1-Arylallyl)pyridine-2-amines with Concomitant C=C Bond Cleavage: A Synthesis of 3-Iodoimidazo[1,2-a]pyridines in 2019.0, Cited 89.0. Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

A facile method for the synthesis of 3-iodoimidazo[1,2-a]pyridines has been successfully developed involving an I2O5-mediated iodocyclization cascade of N-(1-arylallyl)pyridin-2-amines with concomitant C=C bond cleavage. Preliminary mechanistic studies reveal that this protocol might undergo an oxidative cyclization/decarboxylation/iodination sequence in which I2O5 is used as both an oxidant and an iodine source. The present protocol has advantages of wide substrate scope, simple operation, and metal-free conditions.

Formula: C6H5NO. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

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Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Imidazo[1,2-a]pyridine A(3)-Coupling Catalyzed by a Cu/SiO2 Material WOS:000482836400005 published article about ONE-POT SYNTHESIS; 3-COMPONENT COUPLING REACTION; MULTICOMPONENT SYNTHESIS; COPPER; ALKYNE; 2-AMINOPYRIDINES; CYCLOADDITION; CYCLIZATION; PALLADIUM; ALDEHYDES in [de Salles, Helena D.; Benvenutti, Edilson, V; Schneider, Paulo H.] Univ Fed Rio Grande do Sul, Inst Quim, Av Bento Goncalves 9500, BR-91501970 Porto Alegre, RS, Brazil; [da Silva, Tiago L.] Univ Fed Rio de Janeiro, Inst Quim, Av Athos da Silveira Ramos 149,Bloco A, BR-21941909 Rio de Janeiro, RJ, Brazil; [Radatz, Catia S.] Univ Fed Pelotas UFPeI, CCQFA, BR-96010900 Pelotas, RS, Brazil; [Affeldt, Ricardo F.] Univ Fed Santa Catarina, Ctr Ciencias Fis & Matemat, Dept Quim, BR-88040970 Florianopolis, SC, Brazil in 2019.0, Cited 60.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Product Details of 500-22-1

In this work, we report the preparation of a copper-silica material (Cu/SiO2) by a sol-gel methodology and its characterization concerning composition and textural properties. The Cu/SiO2 material was successfully applied as a Lewis acid heterogeneous catalyst for the A(3)-coupling from 2-aminopyridine, aldehydes and alkynes to imidazo[1,2-a]pyridines (45-82%). which are relevant pharmacological scaffolds. The synthesis shows a number of advantages, such as easy separation from the reaction media and the minimal formation of metal aqueous wastes. Investigation of the mechanism supports the involvement of the formation of reaction intermediates inside the pores of the mesoporous material prior to 5-exo-dig cyclization.

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Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Palladium-Catalyzed Decarboxylative Generation and Propargylation of 2-Azaallyl Anions WOS:000475459200017 published article about SUPER-ELECTRON-DONORS; COUPLING REACTION; DOUBLE-BLIND; REGIOSELECTIVITY; VIRIDENOMYCIN; DERIVATIVES; CARBONATES in [Tang, Shaojian; Wei, Wenjing; Yin, Dan; Poznik, Michal; Chruma, Jason J.] Sichuan Univ, Key Lab Green Chem & Technol, Coll Chem, Chengdu 610064, Sichuan, Peoples R China; [Tang, Shaojian; Wei, Wenjing; Yin, Dan; Poznik, Michal; Chruma, Jason J.] Sichuan Univ, Sino British Mat Res Inst, Coll Phys Sci & Technol, Chengdu 610064, Sichuan, Peoples R China in 2019.0, Cited 43.0. Name: 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A palladium-catalyzed decarboxylative propargylation (DcPg) of propargyl 2,2-diphenylglycinate imines was developed. In this process, the nature of the propargyl ester and aryl imine components, as well as the catalyst system and solvent, had a significant impact on the ratio of desired propargylated products vs. allene and/or diene side products that arise via different modes of C-C bond formation. The resulting propargylated products can be transformed readily into useful (Z)-homoallylic amines. Moreover, the regioisomeric diene products could be converted to pharmaceutically-relevant diarylmethyl imines via a two-step Diels-Alder/oxidation process.

Name: 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact Tang, SJ; Wei, WJ; Yin, D; Poznik, MC; Chruma, AO or send Email.

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Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article 1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors WOS:000526403900042 published article about SUBSTITUTED SACCHARIN DERIVATIVES; SECONDARY SULFONAMIDES; IN-VITRO; CANCER; ISOFORM; SCAFFOLD; POTENT; MODEL in [D’Ascenzio, Melissa; Secci, Daniela; Guglielmi, Paolo; Pierini, Marco] Sapienza Univ Rome, Dipartimento Chim & Tecnol Farmaco, I-00185 Rome, Italy; [Carradori, Simone; Zara, Susi] G dAnnunzio Univ Chieti Pescara, Dept Pharm, Via Vestini 31, I-66100 Chieti, Italy; [Cirilli, Roberto] Ist Super Sanita, Ctr Nazl Controllo & Valutaz Farm, I-00161 Rome, Italy; [Poli, Giulio; Tuccinardi, Tiziano] Univ Pisa, Dept Pharm, I-56126 Pisa, Italy; [Angeli, Andrea; Supuran, Claudiu T.] Univ Florence, Neurofarba Dept, Sect Pharmaceut & Nutraceut Sci, I-50019 Florence, Italy; [Angeli, Andrea] Petru Poni Inst Macromol Chem, Ctr Adv Res Bionanoconjugates, Iasi 700487, Romania; [Angeli, Andrea] Petru Poni Inst Macromol Chem, Biopolymers Dept, Iasi 700487, Romania in 2020.0, Cited 44.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Recommanded Product: 3-Pyridinecarboxaldehyde

Two series of saccharin/isoxazole and saccharin/isoxazoline hybrids were synthesized by 1,3-dipolar cycloaddition. The new compounds showed to be endowed with potent and selective inhibitory activity against the cancer-related human carbonic anhydrase (hCA) IX and XII isoforms in the nanomolar range, while no affinity was encountered for off-targets, such as hCA I and II. Successive enantioseparation on a milligram scale of the most representative compounds led to the discovery that (S)-isomers were more potent than their corresponding (R)-enantiomers. Lastly, molecular modeling studies were conducted to define those structural requirements that were responsible for the discrimination among selected human isoforms of carbonic anhydrases. Two nanomolar hCA IX and XII inhibitors were also screened for their selective toxicity against non tumoral primary cells (fibroblasts) and against a breast adenocarcinoma cell line (MCF7) in hypoxic environment. The efficacious combination of these compounds with doxorubicin on MCF7 cells was demonstrated after 72 h of treatment.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article A novel cluster of C-5-curcuminoids: design, synthesis, in vitro antiproliferative activity and DNA binding of bis(arylidene)-4-cyclanone derivatives based on 4-hydroxycyclohexanone scaffold WOS:000481805000030 published article about CIRCULAR-DICHROISM; CURCUMIN; ANTITUMOR; TOXICITY; ANALOGS; 3,5-BIS(ARYLIDENE)-4-PIPERIDONES; CYTOTOXICITY; APOPTOSIS; DELIVERY; CELLS in [Huber, Imre; Perjesi, Pal] Univ Pecs, Dept Pharmaceut Chem, H-7624 Pecs, Hungary; [Zupko, Istvan; Gyovai, Andras] Univ Szeged, Dept Pharmacodynam & Biopharm, H-6720 Szeged, Hungary; [Horvath, Peter; Kiss, Eszter] Semmelweis Univ, Dept Pharmaceut Chem, H-1092 Budapest, Hungary; [Gulyas-Fekete, Gergely; Schmidt, Janos] Univ Pecs, Dept Biochem & Med Chem, H-7624 Pecs, Hungary in 2019.0, Cited 50.0. Quality Control of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A new series (6) of C-5-curcuminoid derivatives (2E,6E-2,6-dibenzylidene-4-hydroxycyclohexanones) is described here with their evaluation for in vitro antiproliferative activities. Evaluation of 31 compounds against human A2780 (ovarian), C33A (cervix) and MDA-MB-231 (breast) cancer cell lines was performed to obtain structure activity relation data. The best performer was (2E,6E)-2,6-bis(3 ‘-nitrobenzylidene)-4-hydroxycyclohexanone (6h) with IC50 values of 0.68 mu M (A2780), 0.69 mu M (C33A) and 0.92 mu M (MDA-MB-231) compared to cisplatin with 1.30 mu M, 3.69 mu M and 19.13 mu M, respectively. According to calculated physicochemical properties some members in series 6, namely (2E,6E)-2,6-bis[(4 ‘-pyridinyl)methylene]-4-hydroxycyclohexanone (6p) [IC50 = 0.76 mu M (A2780), 2.69 mu M (C33A), 1.28 mu M (MDA-MB-231)] seem to have improved bioavailability compared to curcumin. Selected members of series 6 were involved in circular dichroism spectroscopic measurements in order to determine their interaction with natural DNA. Based on these data, we conclude that these derivatives do not bind to DNA in vitro. A proposal is summarized based on mass spectrometric assessment for fingerprint analysis in biological research of such C-5-curcuminoids.

Quality Control of 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact Huber, I; Zupko, I; Gyovai, A; Horvath, P; Kiss, E; Gulyas-Fekete, G; Schmidt, J; Perjesi, P or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2020.0 SYNTHESIS-STUTTGART published article about ORTHO-QUINONE METHIDES; ANTITUMOR AGENTS; DERIVATIVES; PRECURSORS; NUCLEOPHILES; ALKYLATION; ANALOGS in [Osyanin, Vitaly A.; Osipov, Dmitry V.; Melnikova, Irina V.; Korzhenko, Kirill S.; Semenova, Irina A.; Klimochkin, Yuri N.] Samara State Tech Univ, Dept Organ Chem, Fac Chem Technol, 244 Molodogvardeyskaya St, Samara 443100, Russia in 2020.0, Cited 54.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Recommanded Product: 3-Pyridinecarboxaldehyde

A new strategy to 2-aminochromanes through catalyst-free cascade reaction of 3-trifluoroacetyl-4H-chromenes and 4H-chromene-3-carbaldehydes with cyclic secondary amines is presented. The reaction proceeds through subsequent 1,4- and 1,2-additions of amine, bimolecular elimination of trifluoroacetamide or formamide, and 6-exotrig cyclization. The latter stage is a very rare example of addition of phenols to enamines. The obtained semicyclic N,O-acetals were applied as useful precursors for the synthesis of other chromanes.

Recommanded Product: 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact Osyanin, VA; Osipov, DV; Melnikova, IV; Korzhenko, KS; Semenova, IA; Klimochkin, YN or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem