Category: 503000-87-1

Electric Literature of 503000-87-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 503000-87-1, name is 2-Chloro-6-methoxynicotinic acid, molecular formula is C7H6ClNO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Into a 50-mL round-bottom flask was placed 2-chloro-6-methoxypyridine-3-carboxylic acid (900 mg, 4.80 mmol), dichloromethane (10 mL), Nu,Nu-dimethylformamide (~15 muL) and thionyl chloride (2 mL, 24.0 mmol). The resulting solution was stirred for 2.5 hr at 40 C in an oil bath. The resulting mixture was concentrated under vacuum. This was followed by the addition of methanol (10 mL) dropwise with stirring at 0 C. The resulting solution was stirred for 1 hr at room temperature and the resulting mixture was concentrated under vacuum. The residue was purified on a silica gel column with ethyl acetate/petroleum ether (1/19). This resulted in 720 mg (74%) of methyl 2-chloro-6-methoxypyridine-3-carboxylate as a colorless oil.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 503000-87-1, 2-Chloro-6-methoxynicotinic acid.

Reference:
Patent; INCEPTION 1, INC.; JACINTHO, Jason, Duarte; CLARK, Ryan, Christopher; SHENG, Tao; OBALLA, Renata, Marcella; STOCK, Nicholas, Simon; ROPPE, Jeffrey, Roger; (161 pag.)WO2017/192304; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 503000-87-1 ,Some common heterocyclic compound, 503000-87-1, molecular formula is C7H6ClNO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The intermediate 2-chloro-6-methoxynicotinic acid (3.0 g, 16.00 mmol, 1.0 eq),Potassium carbonate (2.48g,17.94 mmol, 1.1 eq) and methyl iodide (3.07 g, 21.6 mmol, 1.4 eq)Add to DMF solution (35mL), heat to 50 CReaction for 12 hours. The reaction was completely detected by LC-MS and was cooled to room temperature.The reaction solution was directly concentrated under reduced pressure.The crude product was purified by silica gel column chromatography (100-200 mesh silica gel)The product was obtained as a white solid (1.5 g, yield: 47%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,503000-87-1, its application will become more common.

Reference:
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; (67 pag.)CN109810041; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem