Category: 504-29-0

Synthetic Route of 504-29-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 504-29-0, name is Pyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

Preparation 47 pyridine-2-amino-5-sulphonic Acid 2-Aminopyridine (80 g, 0.85 mol) was added portionwise over 30 minutes to oleum (320 g) and the resulting solution heated at 140 C. for 4 hours.. On cooling, the reaction was poured onto ice (200 g) and the mixture stirred in an ice/salt bath for a further 2 hours.. The resulting suspension was filtered, the solid washed with ice water (200 ml) and cold IMS (200 ml) and dried under suction to afford the title compound as a solid, (111.3 g). LRMS: m/z 175 (M+1)+.

According to the analysis of related databases, 504-29-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Pfizer Inc.; US6407114; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 504-29-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 504-29-0, name is Pyridin-2-amine, molecular formula is C5H6N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-Aminopyridine (3.1g, 33mmol) and triethylamine(6.9mL, 49mmol) was dissolved in dichloromethane (40mL), 2,2-dimethylpropionyl chloride (4.5mL, 36mmol) was added on an ice bath, and the solution was stirred for 2 hours at the same temperature. Water was added thereto for extraction, the organic layer was sequentially washed with an aqueous solution of saturated sodium bicarbonate and brine, then, dried over anhydrous magnesium sulfate. The solvent was evaporated in vacuo, and the title compound (6.0g, 34mmol, 102%) was obtained as a white solid. 1H-NMR Spectrum (CDCl3) delta(ppm) :1.27 (9H, s), 7.03 (1H, ddd, J=1.1, 4.9, 7.3Hz), 7.68-7.72 (1 H, m), 8.02 (1 H, s), 8.23-8.27 (2H, m).

According to the analysis of related databases, 504-29-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Eisai Co., Ltd.; EP1669348; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 504-29-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 504-29-0, name is Pyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

Manufacturing Example 1-2-1 2,2-Dimethyl-N-pyridin-2-yl-propionamide To a methylene chloride solution (500 mL) of 2-aminopyridine (50.0 g, 531 mmol) were added triethylamine (81.4 mL, 584 mmol) and pivaloyl chloride (71.9 mL, 584 mmol) at 0 C., which was stirred for 4 hours and 30 minutes at room temperature. The reaction solution was partitioned into water and methylene chloride. The organic layer was washed with water and saturated brine and dried over anhydrous magnesium sulfate, and the solvent was evaporated under a reduced pressure. Potassium carbonate (73.4 g, 531 mmol) was added to 300 mL of thus obtained residue methanol solution at 0 C., which was stirred at room temperature for 90 minutes. This reaction solution was partitioned into water and ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate, the solvent was evaporated under a reduced pressure. Heptane (300 mL) was added to the residue, the precipitated solids were collected by filtering, which gave the titled compound (80.2 g, 85%). The filtrate was then concentrated under a reduced pressure, and the residue was purified by silica gel column chromatography (heptane:ethyl acetate=2:1), which gave the titled compound (12.2 g, 13%). 1H-NMR spectrum (DMSO-d6) delta (ppm): 1.22 (9H, s), 7.06-7.09 (1H, m), 7.72-7.77 (1H, m), 8.01-8.03 (1H, m), 8.29-8.31 (1H, m), 9.71 (1H, s).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 504-29-0, Pyridin-2-amine.

Reference:
Patent; MATSUKURA, Masayuki; US2010/331282; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 504-29-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 504-29-0, name is Pyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

Manufacturing Example 1-2-1: 2,2-Dimethyl-N-pyridin-2-yl-propionamide To a methylene chloride (500 mL) solution of 2-aminopyridine (50 g) were added triethylamine (81 mL) and pivaloyl chloride (72 mL) at 0C, which was stirred for 4 hours and 30 minutes at room temperature. Water was added to the reaction solution, and then extraction was performed with methylene chloride. The organic layer was washed with water and saturated brine, and dried over anhydrous magnesium sulfate and filtered, and then the filtrate was concentrated under a reduced pressure. Potassium carbonate (73 g) was added at 0C to a methanol (300 mL) solution of the residue thus obtained, which was stirred for 90 minutes at room temperature. Water was added to the reaction solution, and then extraction was performed with ethyl acetate. The organic layer was washed with saturated brine, then dried over anhydrous magnesium sulfate, and filtered, after which the filtrate was concentrated under a reduced pressure. Heptane (300 mL) was added to the residue, and the precipitated solids were filtered off to obtain the titled compound (80 g). The filtrate was then further concentrated under a reduced pressure, and the residue was purified by silica gel column chromatography (heptane:ethyl acetate = 2:1) to obtain the titled compound (12 g). 1H-NMR spectrum (DMSO-d6) delta (ppm): 1.22 (9H, s), 7.06-7.09 (1H, m), 7.72-7.77 (1 H, m), 8.01-8.03 (1 H, m), 8.29-8.31 (1 H, m), 9.71 (1 H, s).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 504-29-0, Pyridin-2-amine.

Reference:
Patent; Eisai R&D Management Co., Ltd.; EP2065377; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 504-29-0, Adding some certain compound to certain chemical reactions, such as: 504-29-0, name is Pyridin-2-amine,molecular formula is C5H6N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 504-29-0.

2-Aminopyridine (4.7 g,50 mmol) was dissolved in a mixture of water (6 mL),glacial acetic acid (120 mL), and concentrated sulfuricacid (1 mL) preliminarily cooled to room temperature. Upon mixing, iodine (6 g, 23.6 mmol) and NaIO4(1.6 g, 7.5 mmol) were added. The mixture was kept at80C for 4 h, then 200 mL of 10% sodium thiosulfate solution was added and extracted with ethyl acetate(3 ¡Á 150 mL). The organic phase was washed with10% sodium hydroxide solution (3 ¡Á 60 mL) and brine(2 ¡Á 50 mL), dried over anhydrous Na2SO4, evaporated,and purified by flash chromatography (chloroform-ethanol, 50 : 1). Violet powder (10.3 g, 94%);1H NMR: 8.04 (d, J2 2.1, 1H), 7.58 (dd, J2 8.6, 2.2,1H), 6.35 (d, J2 8.6, 1H), 6.10 (br, 2H).

According to the analysis of related databases, 504-29-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Baleeva, N. S.; Baranov, M. S.; Smirnov, A. Yu.; Zaitseva, E. R.; Zaitseva, S. O.; Russian Journal of Bioorganic Chemistry; vol. 46; 1; (2020); p. 120 – 123; Bioorg. Khim.; vol. 46; 1; (2020); p. 120 – 123,4;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

504-29-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 504-29-0, name is Pyridin-2-amine. A new synthetic method of this compound is introduced below.

a Pyridine-2-amino-5-sulphonic Acid 2-Aminopyridine (80 g, 0.85 mol) was added portionwise over 30 minutes to oleum (320 g) and the resulting solution heated at 140 C. for 4 hours. On cooling, the reaction was poured onto ice (200 g) and the mixture stirred in an ice/salt bath for a further 2 hours. The resulting suspension was filtered, the solid washed with ice water (200 ml) and cold IMS (200 ml) and dried under suction to afford the title compound as a solid, 111.3 g; LRMS: m/z 175 (M+1)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,504-29-0, Pyridin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; Grossman, Eric B.; Koppiker, Nandan P.; Leichter, Steven B.; US2003/162782; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

504-29-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 504-29-0, name is Pyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

S1. Dichloromethane (900 g) was added to a 2 L three-neck bottle at room temperature. 2-Aminopyridine (135 g, 1.0 eq), triethylamine (174 g, 1.2 eq), Cool down to 10-20 C, add pivaloyl chloride (189 g, 1.1 eq), After the addition is completed, the system is warmed to 20-25 C, and the reaction is 2-3 h; After the reaction was completed, water was added to the reaction system, and after stirring for 0.5 h, the organic phase was separated. The aqueous phase was extracted with dichloromethane (500 g). Add petroleum ether (800g) directly at 0 C, stir for 2 h, suction filtration, 2-Pentylaminopyridine was obtained in a yield of 83%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 504-29-0, Pyridin-2-amine.

Reference:
Patent; Aisite (Chengdu) Bio-pharmaceutical Co., Ltd.; Luo Jianye; Li Hongqiang; Guo Peng; (10 pag.)CN108675954; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

504-29-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 504-29-0, name is Pyridin-2-amine, the common compound, a new synthetic route is introduced below.

General procedure: To a solution of aniline (1 mmol) in THF (10 mL) were added triethylamine (2 mmol) and pivaloyl chloride (1.2 mmol) at 0 C under inert atmosphere. After stirring for 12 h at room temperature, the triethylammonium chloride was removed by filtration and the filtrate was evaporated under reduced pressure to afford crude product which was washed with heptane to afford pure N-pivaloyl anilines.

Statistics shows that 504-29-0 is playing an increasingly important role. we look forward to future research findings about Pyridin-2-amine.

Reference:
Article; Kathiravan, Subban; Nicholls, Ian A.; Tetrahedron Letters; vol. 58; 1; (2017); p. 1 – 4;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some common heterocyclic compound, 504-29-0, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.504-29-0

To a solution of 2-aminopyridine (50.0 g, 531 mmol) in methylene chloride (500 mL) were added triethylamine (81.4 mL, 584 mmol) and pivaloyl chloride (71.9 mL, 584 mmol) at 0 C., which was stirred for 4 hours and 30 minutes at room temperature. The reaction solution was partitioned into water and methylene chloride. The organic layer was washed with water and saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under a reduced pressure. To a solution of the resulting residue in methanol (300 mL) was added potassium carbonate (73.4 g, 531 mmol) at 0 C., which was stirred for 90 minutes at room temperature. The reaction solution was partitioned into water and ethyl acetate at room temperature. The organic layer was washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate, and the solvent was evaporated under a reduced pressure. Heptane (300 mL) was added to the residue, and the precipitated solids were filtered to obtain the title compound (80.2 g, 85%). The filtrate was then concentrated under a reduced pressure, and the residue was purified by silica gel column chromatography (heptane:ethyl acetate=2:1) to obtain the title compound (12.2 g, 13%). 1H-NMR Spectrum (DMSO-d6) delta (ppm): 1.22 (9H, s), 7.06-7.09 (1H, m), 7.72-7.77 (1H, m), 8.01-8.03 (1H, m), 8.29-8.31 (1H, m), 9.71 (1H, s).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 504-29-0.

Reference:
Patent; Eisai R&D Management Co., Ltd.; US2007/105904; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

504-29-0 , The common heterocyclic compound, 504-29-0, name is Pyridin-2-amine, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Manufacturing Example 39-1-1 2,2-Dimethyl-N-pyridin-2-yl-propionamide; To a solution of 2-aminopyridine (50.0 g, 531 mmol) in methylene chloride (500 mL) were added triethylamine (81.4 mL, 584 mmol) and pivaloyl chloride (71.9 mL, 584 mmol) at 0 C., which was stirred for 4 hours and 30 minutes at room temperature. The reaction solution was partitioned into water and methylene chloride. The organic layer was washed with water and saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under a reduced pressure. To a solution of the resulting residue in methanol (300 mL) was added potassium carbonate (73.4 g, 531 mmol) at 0 C., which was stirred for 90 minutes at room temperature. The reaction solution was partitioned into water and ethyl acetate at room temperature. The organic layer was washed with saturated aqueous sodium chloride and dried over anhydrous magnesium sulfate, and the solvent was evaporated under a reduced pressure. Heptane (300 mL) was added to the residue, and the precipitated solids were filtered to obtain the title compound (80.2 g, 85%). The filtrate was then concentrated under a reduced pressure, and the residue was purified by silica gel column chromatography (heptane:ethyl acetate=2:1) to obtain the title compound (12.2 g, 13%).1H-NMR Spectrum (DMSO-d6) delta (ppm): 1.22 (9H, s), 7.06-7.09 (1H, m), 7.72-7.77 (1H, m), 8.01-8.03 (1H, m), 8.29-8.31 (1H, m), 9.71 (1H, s).

According to the analysis of related databases, 504-29-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Tanaka, Keigo; Yamamoto, Eiichi; Watanabe, Naoaki; US2009/82403; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem