504-29-0 , The common heterocyclic compound, 504-29-0, name is Pyridin-2-amine, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
75.2 g (0.80 mol) Of 2-aminopyridine was dissolved in 88.0 g (0.88 mol) of ethyl acrylate and 20 mL of acetic acid. The mixture was heated to 80C and stirred for 24 hours at the same temperature. -Solvent was removed under vacuum, and the title compound was isolated by vacuum distillation to obtain 77.0 g of ethyl 3-(2- pyridylamino)propionate as a white solid.Yield: 77.Og (49.67%); Purity by HPLC: 98.5%.
According to the analysis of related databases, 504-29-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MEGAFINE PHARMA (P) LTD.; MATHAD, Vijayavitthal Thippannachar; SOLANKI, Pavankumar Vrajlal; UPPELLI, Sekhar Babu; SARODE, Ganesh Gitaram; WO2015/128875; (2015); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem