Category: 50501-38-7

Synthetic Route of 50501-38-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 50501-38-7, name is 6-(Hydroxymethyl)picolinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

The product of the previous step and N,N’-dicyclohexylcarbodiimide (19.3 g, 93.0 mmol) were added to a mixture of DMSO (22 ml) anhydrous H3PO4 (1.4 g) and the reaction was left to stir 1.5 hours. The reaction was filtered and washed with diethyl ether (2 x 30 ml) and water (2 x 30 ml). The reaction layers was separated and the organic layer was washed with saturated brine (2 x 30 ml), dried with MgS04, filtered and evaporated to yield (iib) as a yellow solid which was taken towards the next step without purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 50501-38-7, 6-(Hydroxymethyl)picolinonitrile.

Reference:
Patent; KUDOS PHARMACEUTICALS LIMITED; WO2006/21801; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 50501-38-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 50501-38-7, name is 6-(Hydroxymethyl)picolinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

The product of the previous step and N,N’-dicyclohexylcarbodiimide (19.3 g, 93.0 mmol) were added to a mixture of DMSO (22 ml) anhydrous H3PO4 (1.4 g) and the reaction was left to stir 1.5 hours. The reaction was filtered and washed with diethyl ether (2 x 30 ml) and water (2 x 30 ml). The reaction layers was separated and the organic layer was washed with saturated brine (2 x 30 ml), dried with MgS04, filtered and evaporated to yield (iib) as a yellow solid which was taken towards the next step without purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 50501-38-7, 6-(Hydroxymethyl)picolinonitrile.

Reference:
Patent; KUDOS PHARMACEUTICALS LIMITED; WO2006/21801; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 50501-38-7, Adding some certain compound to certain chemical reactions, such as: 50501-38-7, name is 6-(Hydroxymethyl)picolinonitrile,molecular formula is C7H6N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 50501-38-7.

P4: For alternative syntheses, see [36?38]. The reaction was performed under nitrogen. SeO2 (386 mg, 3.48 mmol) and P3 (933 mg, 6.96 mmol) were stirred in dioxane (30 mL; neither dried nor degassed) at 110°C (bath temperature) for 24 h to give a dark yellow solution and black precipitate of selenium. The mixture was filtered through Celite to remove selenium. Celite was washed with CH2Cl2. Purification by chromatography (10 g of silica; CH2Cl2)gave pale yellow eluate of the product. White solid: 692 mg(5.24 mmol; 75percent; C7H4N2O; MW 132.12).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 50501-38-7, 6-(Hydroxymethyl)picolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Shavaleev, Nail M.; Eliseeva, Svetlana V.; Inorganica Chimica Acta; vol. 427; (2015); p. 81 – 86;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 50501-38-7 , The common heterocyclic compound, 50501-38-7, name is 6-(Hydroxymethyl)picolinonitrile, molecular formula is C7H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Hydroxy-methylpyridine 3b, 7, or 13, 1.9 mmol, was dissolved in 25 mL of 1,2-dichloroethane, 1.65 g (19 mmol) of activated manganese dioxide was added, and the mix-ture was stirred for 6 h at 50°C. The precipitate was filtered off, the filtrate was evaporated under reduced pressure, and the residue was used in the next step without additional purification.

The synthetic route of 50501-38-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Krinochkin; Kopchuk; Chepchugov; Kovalev; Zyryanov; Rusinov; Chupakhin; Russian Journal of Organic Chemistry; vol. 53; 7; (2017); p. 963 – 970; Zh. Org. Khim.; vol. 53; 7; (2017); p. 951 – 958,8;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem