Category: 50816-19-8

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 50816-19-8, is researched, SMILESS is OCCCCCCCCBr, Molecular C8H17BrOJournal, Article, Research Support, Non-U.S. Gov’t, Journal of the American Chemical Society called Buckyball-Based Spherical Display of Crown Ethers for De Novo Custom Design of Ion Transport Selectivity, Author is Li, Ning; Chen, Feng; Shen, Jie; Zhang, Hao; Wang, Tianxiang; Ye, Ruijuan; Li, Tianhu; Loh, Teck Peng; Yang, Yi Yan; Zeng, Huaqiang, the main research direction is Spherical Display Crown Ethers Ion Transport Selectivity.Reference of 8-Bromooctan-1-ol.

Searching for membrane-active synthetic analogs that are structurally simple yet functionally comparable to natural channel proteins has been of central research interest in the past four decades, yet custom design of the ion transport selectivity still remains a grand challenge. Here we report on a suite of buckyball-based mol. balls (MBs), enabling transmembrane ion transport selectivity to be custom designable. The modularly tunable MBm-Cn (m = 4-7; n = 6-12) structures consist of a C60-fullerene core, flexible alkyl linkers Cn (i.e., C6 for n-C6H12 group), and peripherally aligned benzo-3m-crown-m ethers (i.e., m = 4 for benzo-12-crown-4) as ion-transporting units. Screening a matrix of 16 such MBs, combinatorially derived from four different crown units and four different Cn linkers, intriguingly revealed that their transport selectivity well resembles the intrinsic ion binding affinity of the resp. benzo-crown units present, making custom design of the transport selectivity possible. Specifically, MB4s, containing benzo-12-crown-4 units, all are Li+-selective in transmembrane ion transport, with the most active MB4-C10 exhibiting an EC50(Li+) value of 0.13μM (corresponding to 0.13 mol % of the lipid present) while excluding all other monovalent alkali-metal ions. Likewise, the most Na+ selective MB5-C8 and K+ selective MB6-C8 demonstrate high Na+/K+ and K+/Na+ selectivity values of 13.7 and 7.8, resp. For selectivity to Rb+ and Cs+ ions, the most active MB7-C8 displays exceptionally high transport efficiencies, with an EC50(Rb+) value of 105 nM (0.11 mol %) and an EC50(Cs+) value of 77 nM (0.079 mol %).

This compound(8-Bromooctan-1-ol)Reference of 8-Bromooctan-1-ol was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 50816-19-8. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 8-Bromooctan-1-ol, is researched, Molecular C8H17BrO, CAS is 50816-19-8, about The Properties and Role of O-Acyl-ω-hydroxy Fatty Acids and Type I-St and Type II Diesters in the Tear Film Lipid Layer Revealed by a Combined Chemistry and Biophysics Approach. Author is Viitaja, Tuomo; Raitanen, Jan-Erik; Moilanen, Jukka; Paananen, Riku O.; Ekholm, Filip S..

The tear film lipid layer (TFLL) that covers the ocular surface contains several unique lipid classes, including O-acyl-ω-hydroxy fatty acids, type I-St diesters, and type II diesters. While the TFLL represents a unique biol. barrier that plays a central role in stabilizing the entire tear film, little is known about the properties and roles of individual lipid species. This is because their isolation from tear samples in sufficient quantities is a tedious task. To provide access to these species in their pure form, and to shed light on their properties, we here report a general strategy for the synthesis and structural characterization of these lipid classes. In addition, we study the organization and behavior of the lipids at the air-tear interface. Through these studies, new insights on the relationship between structural features, such as number of double bonds and the chain length, and film properties, such as spreading and evaporation resistance, were uncovered.

《The Properties and Role of O-Acyl-ω-hydroxy Fatty Acids and Type I-St and Type II Diesters in the Tear Film Lipid Layer Revealed by a Combined Chemistry and Biophysics Approach》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(8-Bromooctan-1-ol)SDS of cas: 50816-19-8.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 8-Bromooctan-1-ol, is researched, Molecular C8H17BrO, CAS is 50816-19-8, about Design and synthesis of α-naphthoflavone chimera derivatives able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation, the main research direction is alpha naphthoflavone conjugates CYP1B1 degradation drug resistance prostate cancer; CYP1B1; Click reaction; PROTACs; Reversal of drug resistance; α-Naphthoflavone-based conjugates.Computed Properties of C8H17BrO.

Extrahepatic cytochrome P 450 1B1 (CYP1B1), which is highly expressed in various tumors, is an attractive and potential target for cancer prevention, therapy, and reversal of drug resistance. CYP1B1 inhibition is the current predominant therapeutic paradigm to treating CYP1B1-mediated malignancy, but therapeutic effect has little success. Herein, we reported CYP1B1 degradation in place of CYP1B1 inhibition for reversing drug resistance toward docetaxel in CYP1B1-overexpressing prostate cancer cell line DU145 using a PROTAC strategy. Replacing chlorine atom of a CYP1B1 selective inhibitor we found previously with ethynyl, we got the resulting α-naphthoflavone derivative 5 which kept strong inhibition against CYP1B1 (IC50 = 0.4±0.2 nM) and high selectivity. Coupling of 5 with thalidomide derivatives of varying chain lengths afforded conjugates 6A-6D via click reaction. In vitro cell-based assay indicated that 6C was more effective in eliminating drug resistance of CYP1B1-overexpressed DU145 cells compared with other analogs. Western blotting anal. showed CYP1B1 degradation was one main reason for the reversal of drug resistance to docetaxel and the effect was obtained in a concentration-dependent manner. This work is the first attempt to overcome CYP1B1-mediated drug resistance via CYP1B1 degradation instead of CYP1B1 inhibition, which could provide a new direction toward eliminating drug resistance.

《Design and synthesis of α-naphthoflavone chimera derivatives able to eliminate cytochrome P450 (CYP)1B1-mediated drug resistance via targeted CYP1B1 degradation》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(8-Bromooctan-1-ol)Computed Properties of C8H17BrO.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Xue, Dongxiang; Xu, Tiandan; Wang, Huixia; Wu, Meng; Yuan, Ya; Wang, Wei; Tan, Qiwen; Zhao, Fei; Zhou, Fang; Hu, Tao; Jiang, Zhongxing; Liu, Zhi-Jie; Zhao, Suwen; Liu, Dongsheng; Wuethrich, Kurt; Tao, Houchao researched the compound: 8-Bromooctan-1-ol( cas:50816-19-8 ).Category: pyridine-derivatives.They published the article 《Disulfide-Containing Detergents (DCDs) for the Structural Biology of Membrane Proteins》 about this compound( cas:50816-19-8 ) in Chemistry – A European Journal. Keywords: disulfide containing detergent structural biol membrane protein NMR; NMR spectroscopy; detergents; disulfides; membrane proteins; micelle size. We’ll tell you more about this compound (cas:50816-19-8).

Disulfide-containing detergents (DCDs) are introduced, which contain a disulfide bond in the hydrophobic tail. DCDs form smaller micelles than corresponding detergents with linear hydrocarbon chains, while providing good solubilization and reconstitution of membrane proteins. The use of this new class of detergents in structural biol. is illustrated with solution NMR spectra of the human G protein-coupled receptor A2AAR, which is an α-helical protein, and the β-barrel protein OmpX from E. coli.

Different reactions of this compound(8-Bromooctan-1-ol)Category: pyridine-derivatives require different conditions, so the reaction conditions are very important.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Base- and Catalyst-Induced Orthogonal Site Selectivities in Acylation of Amphiphilic Diols, published in 2020-05-15, which mentions a compound: 50816-19-8, Name is 8-Bromooctan-1-ol, Molecular C8H17BrO, Formula: C8H17BrO.

Seeking to selectively functionalize natural and synthetic amphiphiles, we explored acylation of model amphiphilic diols. The use of a nucleophilic catalyst enabled a remarkable shift of the site selectivity from the polar site, preferred in background noncatalyzed or base-promoted reactions, to the apolar site. This tendency was significantly enhanced for organocatalysts comprising an imidazole active site surrounded by long/branched tails. An explanation of these orthogonal modes of selectivity is supported by competitive experiments with monoalc. substrates.

Different reactions of this compound(8-Bromooctan-1-ol)Formula: C8H17BrO require different conditions, so the reaction conditions are very important.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 8-Bromooctan-1-ol, is researched, Molecular C8H17BrO, CAS is 50816-19-8, about Identification of TRAMs as sphingolipid-binding proteins using a photoactivatable and clickable short-chain ceramide analog.Recommanded Product: 50816-19-8.

Ceramide is a lipid mol. that regulates diverse physiol. and pathol. reactions in part through inverting the topol. of certain transmembrane proteins. This topol. inversion is achieved through regulated alternative translocation (RAT), which reverses the direction by which membrane proteins are translocated across the endoplasmic reticulum during translation. However, owing to tech. challenges in studying protein-ceramide interaction, it remains unclear how ceramide levels are sensed in cells to trigger RAT. Here, we report the synthesis of pac-C7-Cer, a photoactivatable and clickable short-chain ceramide analog that can be used as a probe to study protein-ceramide interactions. We demonstrate that translocating chain-associated membrane protein 2 (TRAM2), a protein known to control RAT of transmembrane 4 L6 subfamily member 20, and TRAM1, a homolog of TRAM2, interacted with mols. derived from pac-C7-Cer. This interaction was competed by naturally existing long-chain ceramide mols. We showed that binding of ceramide and its analogs to TRAM2 correlated with their ability to induce RAT of transmembrane 4 L6 subfamily member 20. In addition to probing ceramide-TRAM interactions, we provide evidence that pac-C7-cer could be used for proteome-wide identification of ceramide-binding proteins. Our study provides mechanistic insights into RAT by identifying TRAMs as potential ceramide-binding proteins and establishes pac-C7-Cer as a valuable tool for future study of ceramide-protein interactions.

Different reactions of this compound(8-Bromooctan-1-ol)Recommanded Product: 50816-19-8 require different conditions, so the reaction conditions are very important.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 50816-19-8. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 8-Bromooctan-1-ol, is researched, Molecular C8H17BrO, CAS is 50816-19-8, about Significantly Enhanced Thermotropic Liquid Crystalline Columnar Mesophases in Stereoregular Polymethylenes with Discotic Triphenylene Side Groups. Author is Li, Xiao; Mu, Bin; Chen, Changlong; Chen, Jian; Liu, Jiang; Liu, Feng; Chen, Dongzhong.

Side-chain discotic liquid crystalline polymers (SDLCPs) with discotic (disclike) mesogens (discogens) attached as side groups through flexible spacers constitute a class of fascinating organic polymer semiconducting materials. While so far almost all reported SDLCPs belong to conventional C2 polymers based on polymerization of vinyl monomers, limiting their structure diversities, substitution d., and efficiency promotion. In this article we present the synthesis of a series of syndiotactic polymethylene SDLCPs of Pm(TPn) with discotic triphenylene (TP) side groups of variant peripheral alkoxy substituents (n = 6, 4, 10) and different length alkyl spacers (m = 3, 4, 6, 8, 10, 12) through an indirect two-step rhodium-complex-catalyzed C1 carbene polymerization pathway. The thermal properties and ordered organization structures of the precursor polymers and polymethylene SDLCPs have been systematically investigated with differential scanning calorimetry (DSC) and polarized optical microscopy (POM), especially through synchrotron radiation variable-temperature small/wide-angle X-ray scattering (SAXS/WAXS) analyses. All of the series C1-type syndiotactic polymethylenes with high densely substituted TP side groups exhibit various hierarchical ordered columnar mesophases comparable to that of the typical side-chain C2 polymers of well-defined polyacrylates with TP discogens. Moreover, they possess a remarkably broadened temperature range of columnar structures persistent to very high temperatures in virtue of the stiff helical polymethylene backbone. This work provides a feasible route to prepare the C1-type SDLCPs with high densely substituted functional side groups and may offer an in-depth understanding for the hierarchical organization of ordered columnar structures with significantly increased thermal stability.

Different reactions of this compound(8-Bromooctan-1-ol)SDS of cas: 50816-19-8 require different conditions, so the reaction conditions are very important.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C8H17BrO. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 8-Bromooctan-1-ol, is researched, Molecular C8H17BrO, CAS is 50816-19-8, about Modulation of the Hydrophilicity on Asymmetric Side Chains of Isoindigo-Based Polymers for Improving Carrier Mobility-Stretchability Properties. Author is Yen, Hao-Chi; Lin, Yan-Cheng; Chen, Wen-Chang.

To realize high-performance and intrinsically stretchable materials for field-effect transistor (FET) devices, a plethora of approaches about structure design were explored. Herein, we report a new approach to control the carrier mobility-stretchability properties of the polymers by tuning the hydrophilicity and asym. side-chain combination. A series of isoindigo-bithiophene (II2T)-based semiconducting polymers with three kinds of side chains including carbosilane side chain, semifluorinated side chain, and oligoether side chain were synthesized for investigating the structure-mobility and structure-stretchability relationships. The mol. stacking pattern and orientation of the derived polymers could be controlled by altering the hydrophilicity and asym. side-chain combination. The side chains of carbosilane and oligoether and a semifluorinated side chain could provide an order edge-on stacking, conformability and backbone aggregation, and an irregular solid-state aggregation, resp. Among them, P(Si-O) with oligoether and a carbosilane side chain exhibited an enhanced μh of 0.56 cm2 V-1 s-1, edge-on stacking, and aggregation behavior owing to the favorable intermol. interaction between the oligoether side chain and the asym. side chain to mitigate the steric hindrance. Also, P(Si-O) possessed a remarkable stretchability of (92%,⊥, 82%,‖) orthogonal μh retention under 100% strain and almost unchanged μh was observed after 1000 stretching-releasing cycles at 60% strain. The exptl. results suggested that the combination and hydrophilicity of side chain played a pivotal role in developing semiconducting polymers with a high performance and an intrinsic stretchability.

The article 《Modulation of the Hydrophilicity on Asymmetric Side Chains of Isoindigo-Based Polymers for Improving Carrier Mobility-Stretchability Properties》 also mentions many details about this compound(50816-19-8)Formula: C8H17BrO, you can pay attention to it, because details determine success or failure

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called The synthesis and application of novel benzodithiophene based reactive mesogens with negative wavelength dispersion birefringence, published in 2021, which mentions a compound: 50816-19-8, mainly applied to benzodithiophene mesogen preparation neg wavelength dispersion birefringence, Product Details of 50816-19-8.

In this work, the synthesis of a novel series of reactive mesogen materials designed to exhibit neg. wavelength dispersion birefringence is reported. This series of photopolymerizable materials based on a benzodithiophene core exhibiting either an ‘X’-shaped or ‘T’-shaped geometry were synthesized. Their neg. wavelength dispersion birefringence properties were investigated in aligned films prepared from photo-polymerized reactive mesogen host mixtures The nature of the substituents on the BDT core was found to have a significant impact on performance, and materials with an X-shaped geometry were found to exhibit much higher performance than those with a T-shape.

The article 《The synthesis and application of novel benzodithiophene based reactive mesogens with negative wavelength dispersion birefringence》 also mentions many details about this compound(50816-19-8)Product Details of 50816-19-8, you can pay attention to it, because details determine success or failure

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 8-Bromooctan-1-ol(SMILESS: OCCCCCCCCBr,cas:50816-19-8) is researched.Application of 1194-22-5. The article 《A new synthesis of the sex pheromone of the indian meal moth Plodia Interpunctella hb.(Lepidoptera, Pyralidae)》 in relation to this compound, is published in Revista de Chimie (Bucharest, Romania). Let’s take a look at the latest research on this compound (cas:50816-19-8).

New synthesis of (9Z,12E)-9,12-tetradecadien-1-yl acetate, the sex pheromone of the indian meal moth Plodia interpunctella (Lepidoptera, Pyralidae), were developed. The synthesis was based on a C8+C2=C10 and C10+C4=C14 coupling scheme. The route involves, as the key step, the use of the mercury derivative of the terminal-alkyneω-functionalised as intermediate.The first coupling reaction took place between 1-tertbutoxy-8-bromo-octane and lithium acetylide-ethylendiamine complex obtaining 1-tert-butoxy-dec-9-yne, which is transformed in di[tert-butoxy-dec-9-yne]mercury.In the second coupling reaction, the mercury derivative was directly lithiated and then alkylated with (E)-1-bromo-2-butene obtaining 1-tert-butoxy-(9- yne,12E)-9,12-tetradecaenyne. After stereoselective reduction in the presence of NiP-2 catalyst and acetylation gave (9Z,12E)-9,12-tetradecadien-1-yl acetate with 82% isomeric purity.

Different reactions of this compound(8-Bromooctan-1-ol)HPLC of Formula: 50816-19-8 require different conditions, so the reaction conditions are very important.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem