Category: 50816-19-8

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Main-chain liquid crystalline polymers bearing periodically grafted folding elements, published in 2021, which mentions a compound: 50816-19-8, Name is 8-Bromooctan-1-ol, Molecular C8H17BrO, Electric Literature of C8H17BrO.

A series of main-chain liquid crystalline polymers (MCLCPs) carrying a biphenyl mesogen and a flexible alkylene spacer in the backbone was prepared; a unique feature of these polymers is that they have a non-mesogenic pendant segment, namely, an alkyl, PEG or fluoroalkyl segment, which is periodically located along the backbone. Due to the presence of these periodic substituents, the chain folds in a zigzag fashion, permitting the collocation of the mesogenic biphenyl units within one layer and the pendant segments in alternate layers of a lamellar morphol. generated by these polymers. Most of the polymers were found to exhibit a stable smectic mesophase upon melting that appears to retain the folded chain conformation, which becomes disordered only after the isotropization transition. From the variation of the interlamellar spacing, estimated from SAXS studies, as a function of the pendant alkyl segment length, it was evident that the pendant segments adopted an extended all-trans conformation and these were fully interdigitated. Furthermore, by comparing the d-spacing of a sample that had longer alkylene backbone segments (C10 instead of C6), we were able to show that the linear variation remains valid for an increase in both the length of the pendant alkyl chain as well as that of the backbone alkylene segment. This observation serves as further evidence for the zigzag folded chain conformation adopted by this class of periodically substituted MCLCPs. Furthermore, the study also reveals the role of aromatic mesogens in enhancing the propensity to adopt this conformation and attain lamellar morphologies, wherein the dimensions are regulated by only the grafting d. and the grafted segment length and not by the mol. weight of the polymer.

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Pyridine – Wikipedia,
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Synthetic Route of C8H17BrO. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 8-Bromooctan-1-ol, is researched, Molecular C8H17BrO, CAS is 50816-19-8, about Synthesis of N-Aryl- and N-alkyl-Substituted Imidazolium Silver Complexes: Cytotoxic Screening by Using Human Cell Lines Modelling Acute Myeloid Leukaemia. Author is Alme, Eirin; Toernroos, Karl Wilhelm; Gjertsen, Bjoern Tore; Bjoersvik, Hans-Rene.

A series of N-aryl- and N-alkyl substituted imidazoles has been synthesized and complexed with Ag+ to obtain silver-NHC complexes of the form [Ag(NHC)2]X. These silver-NHC complexes were tested in vitro against the human cell lines HL-60 and MOLM-13, which both model acute myeloid leukemia (AML). A substantial difference in cytotoxicity was revealed varying in the range 13-4 μM and 22-9 μM for HL-60 and MOLM-13, resp. Furthermore, this study revealed that when an alkyl group is installed on the imidazole scaffold, its position substantially influences the cytotoxicity of the corresponding silver NHC complex.

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Pyridine – Wikipedia,
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Category: pyridine-derivatives. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 8-Bromooctan-1-ol, is researched, Molecular C8H17BrO, CAS is 50816-19-8, about Synthesis and glycosidase inhibition of N-substituted derivatives of 1,4-dideoxy-1,4-imino-D-mannitol (DIM). Author is Yang, Lin-Feng; Shimadate, Yuna; Kato, Atsushi; Li, Yi-Xian; Jia, Yue-Mei; Fleet, George W. J.; Yu, Chu-Yi.

N-Substituted derivatives of 1,4-dideoxy-1,4-imino-D-mannitol (DIM), the pyrrolidine core of swainsonine, have been synthesized efficiently and stereoselectively from D-mannose with 2,3:5,6-di-O-isopropylidene DIM I as a key intermediate. These N-substituted derivatives include N-alkylated, N-alkenylated, N-hydroxyalkylated and N-aralkylated DIMs with the carbon number of the alkyl chain ranging from one to nine. The obtained 33 N-substituted DIM derivatives were assayed against various glycosidases, which allowed a systematic evaluation of their glycosidase inhibition profiles. Though N-substitution of DIM decreased their α-mannosidase inhibitory activities, some of the derivatives showed significant inhibition of other glycosidases.

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Electric Literature of C8H17BrO. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 8-Bromooctan-1-ol, is researched, Molecular C8H17BrO, CAS is 50816-19-8, about Supramolecular phenoxy-alkyl maleate-based hydrogels and their enzyme/pH-responsive curcumin release.

Low-mol.-weight gelators that self-assemble via non-covalent interactions have been attracting significant attention due to their good biocompatibility, low toxicity, inherent biodegradability as well as their convenience of design. Enzymically digestible and pH-sensitive hydrogels play an important role in controlled drug delivery applications. In the present study, we synthesized four simple phenoxy alkyl maleate amphiphiles with various hydrophobic chain lengths (C6-C12). The gelation ability of four amphiphiles was examined in a phosphate buffer solution; among them, the maleates with C10 and C12 chain lengths exhibited gelation ability at the min. gelation concentrations (MGC) of 1.6 and 1.3% w/v, resp. These hydrogelators have shown strong three-dimensional crosslinked networks that can capture water mols. The obtained supramol. hydrogels were thoroughly characterized using differential scanning calorimetry (DSC), SEM, d. functional theory (DFT) calculation, X-ray diffraction, and rheol. studies. More importantly, curcumin, a hydrophobic drug, was encapsulated (1% w/v) into the gel core, and its subsequent release was achieved through gel-to-sol transition induced by lipozyme (biol. stimuli). Addnl., the drug-loaded hydrogel exhibited pH-responsive drug release behavior. The drug release behavior was monitored by employing UV-Vis spectroscopy. Overall, the prepared hydrogelators may be useful in the stimuli-responsive delivery of hydrophobic drugs.

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Application In Synthesis of 8-Bromooctan-1-ol. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 8-Bromooctan-1-ol, is researched, Molecular C8H17BrO, CAS is 50816-19-8, about Structural and Functional Analysis of Bacterial Sulfonosphingolipids and Rosette-Inducing Factor 2 (RIF-2) by Mass Spectrometry-Guided Isolation and Total Synthesis.

We have analyzed the abundance of bacterial sulfonosphingolipids, including rosette-inducing factors (RIFs), in seven bacterial prey strains by using high-resolution tandem mass spectrometry (HRMS2) and mol. networking (MN) within the Global Natural Product Social Mol. Networking (GNPS) web platform. Six sulfonosphingolipids resembling RIFs were isolated and their structures were elucidated based on comparative MS and NMR studies. Here, we also report the first total synthesis of two RIF-2 diastereomers and one congener in 15 and eight synthetic steps, resp. For the total synthesis of RIF-2 congeners, we employed a decarboxylative cross-coupling reaction to synthesize the necessary branched α-hydroxy fatty acids, and the Garner-aldehyde approach to generate the capnine base carrying three stereogenic centers. Bioactivity studies in the choanoflagellate Salpingoeca rosetta revealed that the rosette inducing activity of RIFs is inhibited dose dependently by the co-occurring sulfonosphingolipid sulfobacins D and F and that activity of RIFs is specific for isolates obtained from Algoriphagus.

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Pyridine – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 8-Bromooctan-1-ol, is researched, Molecular C8H17BrO, CAS is 50816-19-8, about Structure-activity relationship studies of (E)-3,4-dihydroxystyryl alkyl sulfones as novel neuroprotective agents based on improved antioxidant, anti-inflammatory activities and BBB permeability.COA of Formula: C8H17BrO.

(E)-3,4-dihydroxystyryl alkyl sulfones I [n = 0, 1, 2; R = Et, Pr, Bu, etc.], as new analogs of neurodegenerative agents, were designed and synthesized. The biol. results demonstrated that most of the target compounds preserved antioxidant and anti-inflammatory potency in scavenging reactive free radicals, protecting neuronal cells against neurotoxins such as H2O2, 6-hydroxydopamine and inhibiting lipopolysaccharide (LPS)-induced over-production of NO. Among these compounds, I [n = 2; R = cyclopentyl] exhibited prominent antioxidant activity at low concentration (2.5 μM) in H2O2 model (cell viability = 94.5%). In addition, I [n = 2; R = cyclopentyl] (IC50 = 1.6 μM) displayed better anti-inflammatory activity than that of lead compound 1 (IC50 = 13.4 μM). In view of the outstanding performance of I [n = 2; R = cyclopentyl], the apoptotic rates of H2O2-damaged PC12 cells were detected by Annexin V-FITC/PI assay. I [n = 2; R = cyclopentyl] showed higher potency in inhibition of apoptosis than 1 at low concentration (2.5 μM), consisting with the antioxidant and anti-inflammatory models. Furthermore, with the predicted CNS (+) blood-brain barrier (BBB) permeability (Pe = 6.84 x 10-6 cm s-1), low cytotoxicity and favorable physiochem. properties based on calculation, compound I [n = 2; R = cyclopentyl] can be further developed as a potential multifunctional neuroprotective agent.

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Zhang, Shuaifeng; Li, Chenyue; Wang, Qian; Zhou, Le; Saeed, Mohsin Hassan; Wang, Xiao; Zhang, Lanying; Yang, Zhou; Yang, Huai published the article 《Fluorescence enhancement and encapsulation of quantum dots via a novel crosslinked vinyl-ether liquid crystals/polymer composite film》. Keywords: fluorescence quantum dot crosslinked vinylether liquid crystal polymer.They researched the compound: 8-Bromooctan-1-ol( cas:50816-19-8 ).Name: 8-Bromooctan-1-ol. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:50816-19-8) here.

Fluorescence efficiency and stability of quantum dots (QDs) film, which are both key for optoelectronic device, are relatively difficult to be improved simultaneously. Herein, the facile synthesis of vinyl-ether terminated liquid crystals was reported. Based on the host vinyl-ether liquid crystals, the polymer dispersed vinyl-ether liquid crystals (PDVLC), polymer dispersed crosslinked vinyl-ether liquid crystals (PDCVLC) and fluorine-containing polymer dispersed crosslinked vinyl-ether liquid crystals (F-PDCVLC) QDs films were fabricated in succession by dual-step polymerization As a result, the PDVLC film can realize fluorescence enhancement and tuning, whereas the PDCVLC film not only maintain fluorescence enhancement of PDVLC film but also improve the water-resistant performance. More importantly, the formation of crosslinked film makes it convenient to fabricate QDs film. Subsequently, the F-PDCVLC film can further improve the water-resistant properties by introducing fluorine-containing monomers to enhance the hydrophobic performance. This free-standing (F-) PDCVLC film may offer a new avenue to realize the optimization of QDs film performance.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 8-Bromooctan-1-ol( cas:50816-19-8 ) is researched.Product Details of 50816-19-8.Piras, Monica; Patruno, Ilaria; Nikolakopoulou, Christina; Willment, Janet A.; Sloan, Nikki L.; Zanato, Chiara; Brown, Gordon D.; Zanda, Matteo published the article 《Synthesis of the Fungal Metabolite YWA1 and Related Constructs as Tools to Study MelLec-Mediated Immune Response to Aspergillus Infections》 about this compound( cas:50816-19-8 ) in Journal of Organic Chemistry. Keywords: YWA1 fonsecin B derivative synthesis melLec immune response Aspergillus. Let’s learn more about this compound (cas:50816-19-8).

We describe the chem. synthesis of the fungal naphthopyrones YWA1 (I) and fonsecin B (II), as well as their functionalization with an amine-spacer arm and the conjugation of the resulting mols. to three different functional tags (i.e., biotin, Oregon green, 1-[3-(succinimidyloxycarbonyl)benzyl]-4-[5-(4-methoxyphenyl)-2-oxazolyl]pyridinium bromide (PyMPO)). The naphthopyrone-biotin and -PyMPO constructs maintained the ability to bind the C-type lectin receptor MelLec, whose interaction with immunol. active fungal metabolites (i.e., 1,8-dihydroxynaphthalene-(DHN)-melanin and YWA1) is a key step in host recognition and induction of protective immune responses against Aspergillus fumigatus. The fluorescent Fonsecin B-PyMPO construct III was used to selectively visualize MelLec-expressing cells, thus validating the potential of this strategy for studying the role and functions of MelLec in immunity.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 8-Bromooctan-1-ol( cas:50816-19-8 ) is researched.Computed Properties of C8H17BrO.Wang, Xin; Liu, Jun; Chen, Jinyao; Zhang, Ming; Tian, Chuan; Peng, Xiaoping; Li, Gang; Chang, Wenqiang; Lou, Hongxiang published the article 《Azole-triphenylphosphonium conjugates combat antifungal resistance and alleviate the development of drug-resistance》 about this compound( cas:50816-19-8 ) in Bioorganic Chemistry. Keywords: azole triphenylphosphonium preparation antifungal fungal infection; Azole-resistance; Candida; Erg11; Fluconazole; Mitochondria-targeting. Let’s learn more about this compound (cas:50816-19-8).

Azole antifungals are commonly used to treat fungal infections but have resulted in the occurrence of drug resistance. Therefore, developing azole derivatives (AZDs) that can both combat established drug-resistant fungal strains and evade drug resistance is of great importance. In this study, we synthesized a series of AZDs with a fluconazole (FLC) skeleton conjugated with a mitochondria-targeting triphenylphosphonium cation (TPP+). These AZDs displayed potent activity against both azole-sensitive and azole-resistant Candida strains without eliciting obvious resistance. Moreover, two representative AZDs, I and II, exerted synergistic antifungal activity with Hsp90 inhibitors against C. albicans strains resistant to the combination treatment of FLC and Hsp90 inhibitors. AZD 25, which had minimal cytotoxicity, was effective in preventing C. albicans biofilm formation. Mechanistic investigation revealed that AZD II inhibited the biosynthesis of the fungal membrane component ergosterol and interfered with mitochondrial function. Our findings provide an alternative approach to address fungal resistance problems.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 8-Bromooctan-1-ol, is researched, Molecular C8H17BrO, CAS is 50816-19-8, about Monobromination of α,ω-Diols: Highly Efficient Preparation of Synthetic Intermediates, the main research direction is bromoalc preparation; diol monobromination reaction.Safety of 8-Bromooctan-1-ol.

The present work aimed to evaluate different conditions to perform monobromination reactions of α,ω-diols HOCH2(CH2)nCH2OH (n = 4, 5, 6, 8) using HBr. Three solvents such as, toluene, isooctane, 1,2-dichloroethane were tested in two distinct molar proportions between 1,8-octanediol and HBr (1:1 and 1:2 equiv). All reactions occurred under reflux. After establishing the best reactional conditions, assays with four sym. α,ω-diols, 1,6-hexanediol; 1,7-heptanediol; 1,8-octanediol; and 1,10-decanediol, with 2 equivalent HBr in 1,2-dichloroethane, were conducted. Using toluene as solvent lead to the best reaction yields (81-95%), producing the least amount of unwanted dibrominated product BrCH2(CH2)nCH2Br. Reactions in 1,2-dichloroethane gave similar results to the ones with toluene when 2 equivalent HBr were used. The lowest reactional efficiency registered in these assays occurred in isooctane, forming the highest amount of dibromide. Diols 1,7-heptanediol and 1,8-octanediol showed the best results under the conditions studied, in 1,2-dichloroethane.

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