Category: 50816-19-8

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 50816-19-8, is researched, SMILESS is OCCCCCCCCBr, Molecular C8H17BrOJournal, Article, Research Support, Non-U.S. Gov’t, Bioorganic & Medicinal Chemistry Letters called Synthesis of Isosteviol analogues as potential protective agents against Doxorubicin-induced cardiomyopathy in zebrafish embryos, Author is Jayachandra, R.; Zhao, Haishan; Cheng, Zuchun; Luo, Liping; Sun, Tingwei; Tan, Wen, the main research direction is isosteviol analog preparation cardioprotective; Cardiomyopathy; Cardioprotection; Doxorubicin; Isosteviol analogues; Zebrafish.Electric Literature of C8H17BrO.

Doxorubicin (DOX) is a powerful anthracycline antibiotic agent which is widely used to treat various types of cancers. Despite efficacy, it displays severe cardiotoxic side effects. Discovery of novel and effective protective agents against DOX-induced cardiotoxicity has been a subject of great interest. Herein, we report the synthesis of two series of analogs of Isosteviol (ISV) with modifications at C-16, C-19 positions as the first series and at C-15, C-16 positions as the other series. Interestingly, the second series analogs have shown a potential protective effect against DOX-induced cardiotoxicity in zebrafish embryos in vivo. Further, we have demonstrated that the synthesized new analogs of ISV, prevented the morphol. distortions caused due to DOX cardiotoxicity in zebrafish heart and the associated cardiac impairments.

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Pyridine – Wikipedia,
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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Polymer Chemistry called Enhanced fluorescence quantum yield of syndiotactic side-chain TPE polymers via Rh-catalyzed carbene polymerization: influence of the substitution density and spacer length, Author is Li, Xiao; Sun, Yuhao; Chen, Jian; Wu, Zhongying; Cheng, Pin; Li, Qian; Fang, Jianglin; Chen, Dongzhong, which mentions a compound: 50816-19-8, SMILESS is OCCCCCCCCBr, Molecular C8H17BrO, Reference of 8-Bromooctan-1-ol.

A series of syndiotactic C1 polymers PmTPE with tetraphenylethene (TPE) side groups attached through various length alkyl spacers of carbon numbers m = 2-6, 8, 10, and 12 have been prepared via Rh-catalyzed carbene polymerization, with the homologues with very short spacers encountering quite arduous challenges. All the polymers investigated possess typical aggregation-induced emission (AIE) properties whether in solution aggregates or in solid films and reveal a remarkable increase in fluorescence quantum yields with shortened alkyl spacer lengths, coinciding with the increased glass transition temperatures and in agreement with the same tendency to increase manifested by the TPE-based side-chain C2 polyacrylate polymers. Moreover, they display high fluorescence quantum yields with about 20% increase compared to their usual C2 polymer counterparts with the same side-chain spacer lengths. Their high quantum yields are unaffected by adequate thermal annealing, and they are thermodynamically stable as confirmed by the X-ray scattering anal., indicating an unaltered highly constrained structure, thus significantly promoting the restriction of intramol. rotations (RIR) of TPE luminogens and blocking the non-radiative channels. A testing paper strip coated with representative P4TPE is exemplified as an economical, reusable, and visualized method for TNT explosive detection with high sensitivity. The significant fluorescence emission enhancement of C1 polymers because of the high substitution d. and syndiotactic regularity may provide an inspiring route for the preparation of further upgraded AIE polymer materials for various applications.

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Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dei, Silvia; Braconi, Laura; Trezza, Alfonso; Menicatti, Marta; Contino, Marialessandra; Coronnello, Marcella; Chiaramonte, Niccolo; Manetti, Dina; Perrone, Maria Grazia; Romanelli, Maria Novella; Udomtanakunchai, Chatchanok; Colabufo, Nicola Antonio; Bartolucci, Gianluca; Spiga, Ottavia; Salerno, Milena; Teodori, Elisabetta published an article about the compound: 8-Bromooctan-1-ol( cas:50816-19-8,SMILESS:OCCCCCCCCBr ).Related Products of 50816-19-8. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:50816-19-8) through the article.

In this study, a new series of N,N-bis(alkanol)amine aryl ester heterodimers was synthesized and studied. The new compounds were designed based on the structures of our previous arylamine ester derivatives endowed with high P-gp-dependent multidrug resistance reversing activity on a multidrug-resistant leukemia cell line. All new compounds were active in the pirarubicin uptake assay on the doxorubicin-resistant erythroleukemia K562 cells (K562/DOX). Compounds bearing a linker made up of 10 methylenes showed unprecedented high reversal activities regardless of the combination of aromatic moieties. Docking results obtained by an in silico study supported the data obtained by the biol. tests and a study devoted to establish the chem. stability in phosphate buffer solution (PBS) and human plasma showed that only a few compounds exhibited a significant degradation in the human plasma matrix. Ten selected non-hydrolysable derivatives were able to inhibit the P-gp-mediated rhodamine-123 efflux on K562/DOX cells, and the evaluation of their apparent permeability and ATP consumption on other cell lines suggested that the compounds can behave as unambiguous or not transported substrates. The activity of these the compounds on the transport proteins breast cancer resistance protein (BCRP) and multidrug resistance associated protein 1 (MRP1) was also analyzed. All tested derivatives displayed a moderate potency on the BCRP overexpressing cells; while only four mols. showed to be effective on MRP1 overexpressing cells, highlighting a clear structural requirement for selectivity. In conclusion, we have identified a new very powerful series of compounds which represent interesting leads for the development of new potent and efficacious P-gp-dependent MDR modulators.

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Recommanded Product: 50816-19-8. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 8-Bromooctan-1-ol, is researched, Molecular C8H17BrO, CAS is 50816-19-8, about Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5 C Degraders. Author is Iida, Tetsuya; Itoh, Yukihiro; Takahashi, Yukari; Yamashita, Yasunobu; Kurohara, Takashi; Miyake, Yuka; Oba, Makoto; Suzuki, Takayoshi.

Lysine demethylase 5 C (KDM5C) controls epigenetic gene expression and is attracting great interest in the field of chem. epigenetics. KDM5C has emerged as a therapeutic target for anti-prostate cancer agents, and recently we identified triazole 1 as an inhibitor of KDM5C. Compound 1 exhibited highly potent KDM5C-inhibitory activity in in vitro enzyme assays, but did not show strong anticancer effects. Therefore, a different approach is needed for the development of anticancer agents targeting KDM5C. Here, we attempted to identify KDM5C degraders by focusing on a protein-knockdown strategy. Compound 3 b, which was designed based on compound 1, degraded KDM5C and inhibited the growth of prostate cancer PC-3 cells more strongly than compound 1. These findings suggest that KDM5C degraders are more effective as anticancer agents than compounds that only inhibit the catalytic activity of KDM5C.

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Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Polymer Chemistry called Enhanced fluorescence quantum yield of syndiotactic side-chain TPE polymers via Rh-catalyzed carbene polymerization: influence of the substitution density and spacer length, Author is Li, Xiao; Sun, Yuhao; Chen, Jian; Wu, Zhongying; Cheng, Pin; Li, Qian; Fang, Jianglin; Chen, Dongzhong, which mentions a compound: 50816-19-8, SMILESS is OCCCCCCCCBr, Molecular C8H17BrO, Reference of 8-Bromooctan-1-ol.

A series of syndiotactic C1 polymers PmTPE with tetraphenylethene (TPE) side groups attached through various length alkyl spacers of carbon numbers m = 2-6, 8, 10, and 12 have been prepared via Rh-catalyzed carbene polymerization, with the homologues with very short spacers encountering quite arduous challenges. All the polymers investigated possess typical aggregation-induced emission (AIE) properties whether in solution aggregates or in solid films and reveal a remarkable increase in fluorescence quantum yields with shortened alkyl spacer lengths, coinciding with the increased glass transition temperatures and in agreement with the same tendency to increase manifested by the TPE-based side-chain C2 polyacrylate polymers. Moreover, they display high fluorescence quantum yields with about 20% increase compared to their usual C2 polymer counterparts with the same side-chain spacer lengths. Their high quantum yields are unaffected by adequate thermal annealing, and they are thermodynamically stable as confirmed by the X-ray scattering anal., indicating an unaltered highly constrained structure, thus significantly promoting the restriction of intramol. rotations (RIR) of TPE luminogens and blocking the non-radiative channels. A testing paper strip coated with representative P4TPE is exemplified as an economical, reusable, and visualized method for TNT explosive detection with high sensitivity. The significant fluorescence emission enhancement of C1 polymers because of the high substitution d. and syndiotactic regularity may provide an inspiring route for the preparation of further upgraded AIE polymer materials for various applications.

In addition to the literature in the link below, there is a lot of literature about this compound(8-Bromooctan-1-ol)Reference of 8-Bromooctan-1-ol, illustrating the importance and wide applicability of this compound(50816-19-8).

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dei, Silvia; Braconi, Laura; Trezza, Alfonso; Menicatti, Marta; Contino, Marialessandra; Coronnello, Marcella; Chiaramonte, Niccolo; Manetti, Dina; Perrone, Maria Grazia; Romanelli, Maria Novella; Udomtanakunchai, Chatchanok; Colabufo, Nicola Antonio; Bartolucci, Gianluca; Spiga, Ottavia; Salerno, Milena; Teodori, Elisabetta published an article about the compound: 8-Bromooctan-1-ol( cas:50816-19-8,SMILESS:OCCCCCCCCBr ).Related Products of 50816-19-8. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:50816-19-8) through the article.

In this study, a new series of N,N-bis(alkanol)amine aryl ester heterodimers was synthesized and studied. The new compounds were designed based on the structures of our previous arylamine ester derivatives endowed with high P-gp-dependent multidrug resistance reversing activity on a multidrug-resistant leukemia cell line. All new compounds were active in the pirarubicin uptake assay on the doxorubicin-resistant erythroleukemia K562 cells (K562/DOX). Compounds bearing a linker made up of 10 methylenes showed unprecedented high reversal activities regardless of the combination of aromatic moieties. Docking results obtained by an in silico study supported the data obtained by the biol. tests and a study devoted to establish the chem. stability in phosphate buffer solution (PBS) and human plasma showed that only a few compounds exhibited a significant degradation in the human plasma matrix. Ten selected non-hydrolysable derivatives were able to inhibit the P-gp-mediated rhodamine-123 efflux on K562/DOX cells, and the evaluation of their apparent permeability and ATP consumption on other cell lines suggested that the compounds can behave as unambiguous or not transported substrates. The activity of these the compounds on the transport proteins breast cancer resistance protein (BCRP) and multidrug resistance associated protein 1 (MRP1) was also analyzed. All tested derivatives displayed a moderate potency on the BCRP overexpressing cells; while only four mols. showed to be effective on MRP1 overexpressing cells, highlighting a clear structural requirement for selectivity. In conclusion, we have identified a new very powerful series of compounds which represent interesting leads for the development of new potent and efficacious P-gp-dependent MDR modulators.

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Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 50816-19-8. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 8-Bromooctan-1-ol, is researched, Molecular C8H17BrO, CAS is 50816-19-8, about Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5 C Degraders. Author is Iida, Tetsuya; Itoh, Yukihiro; Takahashi, Yukari; Yamashita, Yasunobu; Kurohara, Takashi; Miyake, Yuka; Oba, Makoto; Suzuki, Takayoshi.

Lysine demethylase 5 C (KDM5C) controls epigenetic gene expression and is attracting great interest in the field of chem. epigenetics. KDM5C has emerged as a therapeutic target for anti-prostate cancer agents, and recently we identified triazole 1 as an inhibitor of KDM5C. Compound 1 exhibited highly potent KDM5C-inhibitory activity in in vitro enzyme assays, but did not show strong anticancer effects. Therefore, a different approach is needed for the development of anticancer agents targeting KDM5C. Here, we attempted to identify KDM5C degraders by focusing on a protein-knockdown strategy. Compound 3 b, which was designed based on compound 1, degraded KDM5C and inhibited the growth of prostate cancer PC-3 cells more strongly than compound 1. These findings suggest that KDM5C degraders are more effective as anticancer agents than compounds that only inhibit the catalytic activity of KDM5C.

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Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Organic Letters called Phosphorylation Organocatalysts Highly Active by Design, Author is Fallek, Amit; Weiss-Shtofman, Mor; Kramer, Maria; Dobrovetsky, Roman; Portnoy, Moshe, which mentions a compound: 50816-19-8, SMILESS is OCCCCCCCCBr, Molecular C8H17BrO, Recommanded Product: 50816-19-8.

The activity of nucleophilic organocatalysts for alc./phenol phosphorylation was enhanced through attaching oligoether appendages to a benzyl substituent on imidazole- or aminopyridine-based active units, presumably because of stabilizing n-cation interactions of the ethereal oxygens with the pos. charged aza-heterocycle in the catalytic intermediates, and was substantially higher than that of known benchmark catalysts for a range of substrates. D. functional theory calculations and the study of analogs having a lower potential for such stabilizing interactions support our hypothesis.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Antibacterial Activity of Hexadecynoic Acid Isomers toward Clinical Isolates of Multidrug-Resistant Staphylococcus aureus, published in 2020-02-29, which mentions a compound: 50816-19-8, mainly applied to hexadecynoate isomer structure antibacterial activity Staphylococcus; Alkynoic fatty acids; Ciprofloxacin-resistant S. aureus; Critical micelle concentration; DNA gyrase; MRSA; Susceptibility tests, Computed Properties of C8H17BrO.

the structural characteristics that impart antibacterial activity to C16 alkynoic fatty acids (aFA) were further investigated. The syntheses of hexadecynoic acids (HDA) containing triple bonds at C-3, C-6, C-8, C-9, C-10, and C-12 were carried out in 4 steps and with an overall yield of 34-78%. In addition, HDA analogs containing a sulfur atom at either C-4 or C-5 were also prepared in 69-77% overall yields, resp. the triple bond at C-2 is pivotal for the antibacterial activity displayed by 2-HDA, while the farther the position of the triple bond from the carbonyl group, the lower its bactericidal activity against gram-pos. bacteria, including clin. isolates of methicillin-resistant Staphylococcus aureus (CIMRSA) strains. The potential of 2-HDA as an antibacterial agent was also assessed in 5 CIMRSA strains that were resistant to Ciprofloxacin (Cipro) demonstrating that 2-HDA was the most effective treatment in inhibiting their growth when compared with either Cipro alone or equimolar combinations of Cipro and 2-HDA. Moreover, it was proved that the inhibition of S. aureus DNA gyrase can be linked to the antibacterial activity displayed by 2-HDA. Finally, it was determined that the ability of HDA analogs to form micelles can be linked to their decreased activity against gram-pos. bacteria, since critical micellar concentrations of 50-300 μg/mL were obtained.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 8-Bromooctan-1-ol(SMILESS: OCCCCCCCCBr,cas:50816-19-8) is researched.Synthetic Route of C10H24N2. The article 《Graphene Oxide Nanosheets Shielding of Lipase Immobilized on Magnetic Composites for the Improvement of Enzyme Stability》 in relation to this compound, is published in ACS Sustainable Chemistry & Engineering. Let’s take a look at the latest research on this compound (cas:50816-19-8).

In this study, a novel enzyme immobilization method was developed to enhance the catalytic stability of enzymes. In this strategy, ionic liquid (IL) modified magnetic chitosan (MCS) composites were used as supports for lipase adsorption and graphene oxide (GO) was employed as shell coating for the first time. The modifier used was imidazolium-based IL with a side alkyl chain which was composed of 8 -CH2 and a terminal hydroxyl group. The prepared supports IL-MCS, immobilized lipase PPL-IL-MCS, and GO/PPL-IL-MCS were well characterized. The GO shielding lipase GO/PPL-IL-MCS maintained high activity (2468 U/g), which was 6.72-fold of free lipase. In addition, the pH and temperature effect on lipase activity were investigated. The thermal stability, denaturants stability, storage stability, and reusing stability were also studied. Compared to PPL-IL-MCS, the stabilities of GO/PPL-IL-MCS were all enhanced while keeping high activity. For example, after 10 cycles of reuse, the residual activity of GO/PPL-IL-MCS was 92.1%, which was higher than that of 88.4% for PPL-IL-MCS. Furthermore, the apparent Km of PPL-IL-MCS and GO/PPL-IL-MCS was 5.7 and 8.8 mg/mL, resp., which were both lower than that of PPL-MCS (17.1 mg/mL). CD was used to analyze the secondary structure of lipase to explain the mechanism of stable enhancement of immobilized enzyme. This work demonstrated that GO was used as a shell coating for the first time to improve the lipase stability. This immobilization method provides a reference for the immobilization of other kinds of enzymes.

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