Category: 51566-22-4

On May 14, 1991, Yamaji, Mitsuharu published a patent.Safety of 3-Methylpyridine-2,6-diamine The title of the patent was Preparation of 3-alkyl-2,6-diaminopyridines as developers for hair dyes. And the patent contained the following:

The diaminopyridines are prepared by treating 3-alkyl-2-aminopyridines with alkali metal amides in inert solvents and quenching the reaction mixtures with OH-containing compounds Thus, a solution of NaNH2 in Tetralin was treated dropwise with 2-amino-3-methylpyridine, then the mixture was quenched with H2O to give 62% 3-methyl-2,6-diaminopyridine. The experimental process involved the reaction of 3-Methylpyridine-2,6-diamine(cas: 51566-22-4).Safety of 3-Methylpyridine-2,6-diamine

The Article related to hair dye developer alkyldiaminopyridine, aminopyridine amination alkali amide, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Other Dyes and Pigments and other aspects.Safety of 3-Methylpyridine-2,6-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 20, 1997, Kawano, Eiji; Nagai, Masashi; Inubushi, Atsurou; Shimada, Keiichi; Tobari, Hiroko published a patent.Category: pyridine-derivatives The title of the patent was Nitrogen monoxide synthetase inhibitor comprising 2-aminopyridines as active ingredient. And the patent contained the following:

A nitrogen monoxide synthetase (NOS) inhibitor which contains as the active ingredient 2-aminopyridines or pharmaceutically acceptable salts thereof. It has been found that 2-aminopyridines and pharmaceutically acceptable salts thereof have potent effects of inhibiting nitrogen monoxide synthetase. Namely, a medicinal composition containing 2-aminopyridines and pharmaceutically acceptable salts thereof is useful as a nitrogen monoxide formation inhibitor for treatment of NOS-related diseases e.g. septic shock, rheumatism, allergy, parkinsonism, cardiovascular diseases, obesity, and pain. The experimental process involved the reaction of 3-Methylpyridine-2,6-diamine(cas: 51566-22-4).Category: pyridine-derivatives

The Article related to nitrogen monoxide synthetase inhibitor aminopyridine preparation, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 10, 2008, Minter, Aaron; Stokes, Berlin published a patent.HPLC of Formula: 51566-22-4 The title of the patent was Preparation of diaminopyridines from glutarimidines. And the patent contained the following:

I is prepared by contacting II with a chem. oxidant and/or a dehydrogenation catalyst in liquid ammonia neat, or in a mixture of liquid ammonia and a polar, aprotic solvent, to form a reaction mixture; and heating the reaction mixture to produce I; wherein R1 and R2 are each independently selected from (a) H; (b) a hydrocarbyl group; (c) NR3R4 wherein R3 and R4 are each independently selected from H and a hydrocarbyl group; (d) -CO-R5wherein R5 is a hydrocarbyl group; and (e) YR6 wherein Y is selected from O and S and R6 is selected from H , a hydrocarbyl group, and -COR5 wherein R5 is a hydrocarbyl group. Thus, glutarimidine (111 mg, 0.99 mmol) was combined with Pd-C (100 mg, 0.10 mmol, 10 mol% of 10% Pd on carbon), and then mixed with liquidNH3 (1.0 g, 58.7 mmol) then heated at 200° for 45 h to give 0.14 mmol of 2,6-diaminopyridine in yield 13.7%. The experimental process involved the reaction of 3-Methylpyridine-2,6-diamine(cas: 51566-22-4).HPLC of Formula: 51566-22-4

The Article related to glutarimidine dehydrogenation diaminopyridine preparation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.HPLC of Formula: 51566-22-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 27, 2011, Minter, Aaron; Stokes, Berlin published a patent.Quality Control of 3-Methylpyridine-2,6-diamine The title of the patent was Process for the synthesis of diaminopyridines from glutarimidines. And the patent contained the following:

A liquid-phase process is provided for the synthesis from glutarimidines of diaminopyridines and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process. The experimental process involved the reaction of 3-Methylpyridine-2,6-diamine(cas: 51566-22-4).Quality Control of 3-Methylpyridine-2,6-diamine

The Article related to glutarimidine dehydrogenation diaminopyridine preparation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Quality Control of 3-Methylpyridine-2,6-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 10, 2008, Minter, Aaron; Stokes, Berlin published a patent.Application of 51566-22-4 The title of the patent was Preparation of diaminopyridines from glutaronitriles. And the patent contained the following:

I is prepared by contacting II with a chem. oxidant and/or a dehydrogenation catalyst in liquid ammonia neat, or in a mixture of liquid ammonia and a polar, aprotic solvent, to form a reaction mixture; and heating the reaction mixture to produce I; wherein R1 and R2 are each independently selected from (a) H; (b) a hydrocarbyl group; (c) NR3R4 wherein R3 and R4 are each independently selected from H and a hydrocarbyl group; (d) -CO-R5wherein R5 is a hydrocarbyl group; and (e) YR6 wherein Y is selected from O and S and R6 is selected from H , a hydrocarbyl group, and -COR5 wherein R5 is a hydrocarbyl group. Thus, glutaronitrile (3.0 g, 31.9 mmol) was combined with Pd-C (3.39 g, 3.19 mmol, 10 mol% of 10% Pd on carbon) and mixed with liquid NH3 (1.0 g, 58.7 mmol), then heated at 200° for 45 h and a pressure of approx. 90 psi to give 2.43 mmol of 2,6-diaminopyridine in 7.6 % net yield. The experimental process involved the reaction of 3-Methylpyridine-2,6-diamine(cas: 51566-22-4).Application of 51566-22-4

The Article related to glutaronitrile amination dehydrogenation diaminopyridine preparation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Application of 51566-22-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On September 20, 2011, Minter, Aaron; Stokes, Berlin published a patent.Name: 3-Methylpyridine-2,6-diamine The title of the patent was Process for the synthesis of diaminopyridines from glutaronitriles. And the patent contained the following:

A liquid-phase process is provided for the manufacture from glutaronitriles and related compounds of 2,6-diaminopyridine and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process. The experimental process involved the reaction of 3-Methylpyridine-2,6-diamine(cas: 51566-22-4).Name: 3-Methylpyridine-2,6-diamine

The Article related to glutaronitrile amination dehydrogenation diaminopyridine preparation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Name: 3-Methylpyridine-2,6-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 14, 1991, Yamaji, Mitsuharu published a patent.Safety of 3-Methylpyridine-2,6-diamine The title of the patent was Preparation of 3-alkyl-2,6-diaminopyridines as developers for hair dyes. And the patent contained the following:

The diaminopyridines are prepared by treating 3-alkyl-2-aminopyridines with alkali metal amides in inert solvents and quenching the reaction mixtures with OH-containing compounds Thus, a solution of NaNH2 in Tetralin was treated dropwise with 2-amino-3-methylpyridine, then the mixture was quenched with H2O to give 62% 3-methyl-2,6-diaminopyridine. The experimental process involved the reaction of 3-Methylpyridine-2,6-diamine(cas: 51566-22-4).Safety of 3-Methylpyridine-2,6-diamine

The Article related to hair dye developer alkyldiaminopyridine, aminopyridine amination alkali amide, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Other Dyes and Pigments and other aspects.Safety of 3-Methylpyridine-2,6-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem