Category: 5223-06-3

Electric Literature of 5223-06-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 5223-06-3 as follows.

General procedure: To a solution of A1B1 (1.0mmol) and triphenylphosphine (1.5mmol) in anhydrous tetrahydrofuran (3mL), added C1 or C2 (2.0mmol) and dropwise added diethyl azodicarboxylate (DEAD, 1.5mmol) in anhydrous and anoxybiotic conditions. The reaction mixture was stirred at-2C for 30min, and then stirred at room temperature for 24h. After completion of reaction was monitored through TLC, the reaction mixture was filtered and washed with ether and saturated salt water to get products because there would be a solid precipitate.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5223-06-3, its application will become more common.

Reference:
Article; Wang, Fang; Sun, Jun-Rong; Huang, Mei-Yan; Wang, Hui-Ying; Sun, Ping-Hua; Lin, Jing; Chen, Wei-Min; European Journal of Medicinal Chemistry; vol. 72; (2014); p. 35 – 45;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 5223-06-3, 2-(5-Ethylpyridin-2-yl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C9H13NO, blongs to pyridine-derivatives compound. Computed Properties of C9H13NO

General procedure: To a solution of A1B1 (1.0mmol) and triphenylphosphine (1.5mmol) in anhydrous tetrahydrofuran (3mL), added C1 or C2 (2.0mmol) and dropwise added diethyl azodicarboxylate (DEAD, 1.5mmol) in anhydrous and anoxybiotic conditions. The reaction mixture was stirred at-2C for 30min, and then stirred at room temperature for 24h. After completion of reaction was monitored through TLC, the reaction mixture was filtered and washed with ether and saturated salt water to get products because there would be a solid precipitate.

The synthetic route of 5223-06-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Wang, Fang; Sun, Jun-Rong; Huang, Mei-Yan; Wang, Hui-Ying; Sun, Ping-Hua; Lin, Jing; Chen, Wei-Min; European Journal of Medicinal Chemistry; vol. 72; (2014); p. 35 – 45;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 5223-06-3 ,Some common heterocyclic compound, 5223-06-3, molecular formula is C9H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 100 g (0.655 mol) [2- (5-ETHYL-PYRIDIN-2-YL)-ETHANOL] in 500 mL acetic acid was added 118 g (1.049 mol) 30% hydrogen peroxide at 25-30 [C.] Reaction mixture was refluxed at 100 [C] [(TLC)] for 14 hr. After completion of the reaction acetic acid was removed under vacuum, and the residual mass was poured in excess water and made alkaline by 10% [NA2C03] solution. Product was extracted with ethyl acetate and after concentrating ethyl acetate [IN VACUO, 89. 58 G (81%)] crystalline product was obtained. The product obtained was characterized by Mass, [13C] NMR, [AND’H] NMR, which are as given below. Mass spectrum (m/z) : 168. 1 (M + [H) +] [3C-NMR] [(CDC13)] [: 6] 170.7, 148.2, 138.7, 135.9, 125. 8,62. 0,34. 2,25. 5, 14.4 ‘H-NMR [(CDC13)] : [S] 7.07-8. 14 (3H, m), 5.7 [(1H,] broad s), 3.9 (2H, t), 3.2 (2H, t), 2.6 (2H, q), 1.2 (3 H, t)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5223-06-3, its application will become more common.

Reference:
Patent; CADILA HEALTHCARE LIMITED; WO2004/7490; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 5223-06-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5223-06-3, name is 2-(5-Ethylpyridin-2-yl)ethanol, molecular formula is C9H13NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(a) To a solution of 2-(5-ethyl-2-pyridyl)ethanol (53.0 g) and 4-fluoronitrobenzene (47.0 g) in DMF (500 ml) was added portionwise under ice-cooling 60% sodium hydride in oil (16.0 g). The mixture was stirred under ice-cooling for one hour, then at room temperature for 30 minutes, poured into water and extracted with ether. The ether layer was washed with water and dried (MgSO4). The solvent was evaporated off to give 4-[2-(5-ethyl-2-pyridyl)ethoxy]nitrobenzene as crystals (62.0 g, 62.9%). Recrystallization from ether-hexane gave colorless prisms, m.p. 53-54 C.

According to the analysis of related databases, 5223-06-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US4687777; (1987); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 5223-06-3, Name is 2-(5-Ethylpyridin-2-yl)ethanol, SMILES is CCC1=CN=C(CCO)C=C1, in an article , author is Kalkman, Eric D., once mentioned of 5223-06-3, Formula: https://www.ambeed.com/products/5223-06-3.html.

Unusual Electronic Effects of Ancillary Ligands on the Perfluoroalkylation of Aryl Iodides and Bromides Mediated by Copper(I) Pentafluoroethyl Complexes of Substituted Bipyridines

Several perfluoroalkylcopper compounds have been reported previously that serve as reagents or catalysts for the perfluoroalkylation of aryl halides. However, the relationships between the reactivity of such complexes and the electronic properties of the ancillary ligands are unknown, and such relationships are not well-known in general for copper complexes that mediate or catalyze cross coupling. We report the synthesis and characterization of a series of pentafluoroethylcopper(I) complexes ligated by bipyridine ligands possessing varied electronic properties. In contrast to the limited existing data on the reactivity of L2Cu(I)-X complexes bearing amine and pyridine-type ligands in Ullmann-type aminations with aryl halides, the reactions of aryl halides with pentafluoroethylcopper(I) complexes bearing systematically varied bipyridine ligands were faster for complexes bearing less electron-donating bipyridines than for complexes bearing more electron-donating bipyridines. Analysis of the rates of reaction and the relative populations of the neutral complexes [(R(2)bpy)CuC2F5] and ionic complexes [(R(2)bpy)(2)Cu][Cu(C2F5)(2)] formed by these reagents in solution suggests that this effect of electronics on the reaction rate results from an unusual trend of faster oxidative addition of aryl halides to [(R(2)bpy)CuC2F5] complexes containing less electron-donating R(2)bpy ligands than to those containing more electron-donating R(2)bpy ligands.

Interested yet? Read on for other articles about 5223-06-3, you can contact me at any time and look forward to more communication. Formula: https://www.ambeed.com/products/5223-06-3.html.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Application of 5223-06-3, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 5223-06-3, Name is 2-(5-Ethylpyridin-2-yl)ethanol, SMILES is CCC1=CN=C(CCO)C=C1, belongs to pyridine-derivatives compound. In a article, author is Macha, Baswaraju, introduce new discover of the category.

Molecular hybridization based design and synthesis of new benzo[5,6]chromeno[2,3-b]-quinolin-13(14H)-one analogs as cholinesterase inhibitors

A Series of new tacrine analogs were designed, synthesized, characterized by respective spectral data and evaluated for cholinesterase inhibitory activity to be useful in Alzheimer’s disease. Most of the synthesized compounds showed good in vitro inhibitory activities toward acetyl cholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. Among the compounds, 6i, 6o and 6r with increased saturated carboxylic ring size attached to the pyridine moiety and having 3,4-dihydroxy, 3,4,5-trimethoxy substituents on the aromatic ring attached at the stereogenic center have shown equal potency to that of tacrine with IC(50)values 0.65 +/- 0.06, 1.32 +/- 0.02 and 0.85 +/- 0.05, 1.65 +/- 0.12 and 0.92 +/- 0.03, 1.91 +/- 0.12 mu M against AChE and BuChE, respectively. Standard drug tacrine exhibited IC50 values of 0.47 +/- 0.02 and 0.65 +/- 0.08, while Donepezil showed IC50 0.71 +/- 0.06 and 0.31 +/- 0.04 mu M against AChE and BuChE, respectively. Docking studies of all the molecules disclosed close hydrogen bond interactions with the binding site.

Application of 5223-06-3, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 5223-06-3.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Name: 2-(5-Ethylpyridin-2-yl)ethanol5223-06-3, Name is 2-(5-Ethylpyridin-2-yl)ethanol, SMILES is CCC1=CN=C(CCO)C=C1, belongs to pyridine-derivatives compound. In a article, author is Liang, Peng, introduce new discover of the category.

Effects of ionic liquid pretreatment on pyrolysis characteristics of a high-sulfur bituminous coal

Four different ionic liquids (ILs) were used to identify their extraction properties on high-sulfur bituminous coal. And the effect of ILs pretreatment on pyrolysis characteristic was investigated in a fixed-bed reactor. The imidazolium-based ILs used namely: 1-butyl-3-methyl-imidazolium chloride ([Bmim]Cl), 1-butyl-3-methyl-imidazolium bromide ([Bmim]Br), 1-butyl-3-methylimidazolium hydrogen sulfate ([Bmim]HSO4), 1-butyl-3-methyl-imidazolium tetrafluoroborate ([Bmim]BF4). All the selected ILs exhibited extraordinary extraction ability for oxygen-containing compounds, mainly furans and ethers. Among them, [Bmim]Cl got the highest extraction yields of 20.82% and performed selective extraction ability for sulfur-containing compounds with a relative content of 5.10% in light oils. Compared with pyridine pretreated coal (R-PY), the yields of CO and CO2 in pyrolysis gas showed increase trend when coal pretreated by ILs (R-ILs). The relative contents of tricyclic and larger PAHs, sulfur-containing compounds, and oxygen-containing compounds in tar from pyrolysis of [Bmim]Cl and [Bmim] Br treated coal increased significantly than R-PY tar, while phenols got decreased. High carbon number components from R-ILs tar reduced dramatically compared with R-PY tar, which was conducive to the upgrading of tar, after pretreated with ILs, the sulfur content was reduced. The crosslinks between coal macromolecules structure were destroyed after pretreated by ILs, and the pyrolysis products distribution had evident change. The oil phase yield got a substantial increase while [Bmim]Cl obtained highest oil yield of 24.89%.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 5223-06-3. Name: 2-(5-Ethylpyridin-2-yl)ethanol.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 5223-06-3, Name is 2-(5-Ethylpyridin-2-yl)ethanol, molecular formula is C9H13NO, belongs to pyridine-derivatives compound, is a common compound. In a patnet, author is Wang, Yu-Hui, once mentioned the new application about 5223-06-3, Safety of 2-(5-Ethylpyridin-2-yl)ethanol.

Hydrogen abstraction of alkyl radicals from polycyclic aromatic hydrocarbons and heterocyclic aromatic hydrocarbons

To understand the condensation during heavy oil thermal processing, the formation of aromatic carbon radicals by H-abstraction of methyl radicals ((CH3)-C-center dot) or ethyl radicals ((C2H5)-C-center dot) from polycyclic aromatic hydrocarbons (PAHs) or heterocyclic aromatic hydrocarbons (hetero-PAHs) was studied by density functional calculation. The H-abstraction from different PAHs all has a positive standard state Gibbs free energy change, while increasing reaction temperature or radical concentration promotes the reaction to proceed spontaneously. (CH3)-C-center dot mainly contributes to the formation of aromatic carbon radicals on PAHs, and the activation entropy of H-abstraction determines the difference in reaction rate constants. The particularity of H-abstraction from hetero-PAHs is reflected at the alpha-site of heterocycles. The H abstraction from N-containing hetero-PAHs occurs preferentially at the alpha-site of heterocycles, and both (CH3)-C-center dot and (C2H5)-C-center dot could participate in abstracting the alpha-H. The H-abstraction from S-containing hetero-PAHs occurs preferentially on coupled aromatic rings, showing reaction behavior similar to the H-abstraction on PAHs. (C) 2020 Elsevier Ltd. All rights reserved.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 5223-06-3. The above is the message from the blog manager. Safety of 2-(5-Ethylpyridin-2-yl)ethanol.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Synthetic Route of 5223-06-3, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 5223-06-3, Name is 2-(5-Ethylpyridin-2-yl)ethanol, SMILES is CCC1=CN=C(CCO)C=C1, belongs to pyridine-derivatives compound. In a article, author is Feng, Caiting, introduce new discover of the category.

Phosphotungstic Acid Supported on Magnetic Mesoporous Tantalum Pentoxide Microspheres: Efficient Heterogeneous Catalysts for Acetalization of Benzaldehyde with Ethylene Glycol

In this study, magnetically-recoverable core-shell catalysts with different amount of H3PW12O40 loading [Fe3O4@C@mTa(2)O(5)-NH2-PW12 (w%)] were prepared by the application of phosphotungstic acid supported on amino group functionalized magnetic core-shell mesoporous tantalum pentoxide microspheres. The prepared samples were characterized by FT-IR, N-2-adsorption-desorption isotherms, TEM, SEM, Pyridine-IR analysis, XRD and magnetism. Fe3O4@C@mTa(2)O(5)-NH2-PW12 samples present both Bronsted and Lewis acidity, large BET surface area and high magnetization. The catalytic activity was evaluated by the acetalization of different aldehydes with diols, and the results show that Fe3O4@C@mTa(2)O(5)-NH2-PW12 (14.47%) catalyst exhibits the highest catalytic activity for acetalization of aldehydes with glycols with 94.5% conversion of benzaldehyde and 99% selectivity to benzaldehyde glycol acetal at 80 degrees C. The catalytic activity of the catalyst for acetalization is related to its total acidity and Bronsted-Lewis acid synergy. The catalyst Fe3O4@C@mTa(2)O(5)-NH2-PW12 can be easily recovered and reused for at least 5 times without obvious decrease of catalytic activity. [GRAPHICS] .

Synthetic Route of 5223-06-3, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 5223-06-3.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Application In Synthesis of 2-(5-Ethylpyridin-2-yl)ethanol5223-06-3, Name is 2-(5-Ethylpyridin-2-yl)ethanol, SMILES is CCC1=CN=C(CCO)C=C1, belongs to pyridine-derivatives compound. In a article, author is Zhang, Qiuyue, introduce new discover of the category.

Fluorinated cobalt catalysts and their use in forming narrowly dispersed polyethylene waxes of high linearity and incorporating vinyl functionality

A family of six bis(arylimino)pyridine-cobalt(ii) chloride complexes, [2-{CMeN(2-F-4,6-((4-FC6H4)(2)CH)(2)C6H2)}-6-(CMeNAr)C5H3N]CoCl2 (Ar = 2,6-Me(2)C(6)H(3)Co1, 2,6-Et(2)C(6)H(3)Co2, 2,6-i-Pr(2)C(6)H(3)Co3, 2,4,6-Me(3)C(6)H(2)Co4, 2,6-Et-4-MeC(6)H(2)Co5) and [2-[CMeN{2-{(4-FC6H4)(2)CH}-4-{CH(C6H5)Ar-F}-6-F}]-6-(CMeN(2,6-i-Pr2C6H3))C5H3N]CoCl2 (Ar-F = (3-(4-FC6H4)(2)CH-4-NH2-5-F)C6H2) (Co6), each incorporating one ortho-fluoride and one ortho-bis(4-fluorophenyl)methyl group, has been synthesized in good yield from the corresponding unsymmetrical N,N,N ‘-ligands, L1-L6. All complexes have been well characterized including by F-19 NMR spectroscopy; a variable temperature F-19 NMR study has also been performed on Co6 to investigate a dynamic isomerization process. The molecular structures of Co1 and Co5 emphasize the variation in steric protection of the metal center imparted by the inequivalent N-aryl groups. In the presence of methylaluminoxane (MAO) or modified methylaluminoxane (MMAO), Co1-Co5 exhibited high activities of up to 11.7 x 10(6) g of polyethylene (PE) (mol of Co)(-1) h(-1) at 70 degrees C, delivering strictly linear, low molecular weight PE waxes (between 924 and 5550 g mol(-1)) of narrow dispersity and terminated with vinyl functionality. By comparison, Co6, possessing a more extended fluorinated para-CH(C6H5)Ar-F group, was the least active but afforded the highest molecular weight polyethylene (up to 10 027 mol(-1)). In addition, DFT studies of the model Co(i)-propyl species, Co1 ‘, Co3 ‘ and Co6 ‘, have been performed in an attempt to explain the favorable formation of the low molecular weight polymers.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 5223-06-3. Application In Synthesis of 2-(5-Ethylpyridin-2-yl)ethanol.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem