Category: 52311-20-3

Related Products of 52311-20-3, Adding some certain compound to certain chemical reactions, such as: 52311-20-3, name is 2-Amino-4-ethoxypyridine,molecular formula is C7H10N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52311-20-3.

Preparation 62 A mixture of (3-chloro-2-oxobutylidene)triphenylphosphorane (12.7 g) and 3-benzyloxy-4-nitrobenzaldehyde (8.9 g) in dioxane (130 ml) was heated under reflux for 2 hours. The solvent was evaporated in vacuo and the residue was dissolved in isopropyl alcohol (130 ml). To the solution was added 2-amino-4-ethoxypyridine (12.0 g) and the mixture was heated under reflux for 2.5 hours. Evaporation of the solvent gave a residue, which was dissolved in a mixture of ethyl acetate and water. The mixture was adjusted to pH 1 with 6N-hydrochloric acid and the isolated precipitate was collected by filtration. To the precipitate was added a mixture of tetrahydrofuran, ethyl acetate and water, and the mixture was adjusted to pH 8 with 20% aqueous potassium carbonate solution with salting-out technique. The separated organic layer was washed with brine and dried over magnesium sulfate. The solvent was evaporated and the residue was triturated with a mixture of diethyl ether and diisopropyl ether. The precipitate was collected by filtration and dried to give 2-[2-(3-benzyloxy-4-nitrophenyl)vinyl]-7-ethoxy-3-methylimidazo[1,2-a]pyridine (3.94 g). mp: 153-154 C. IR (Nujol): 1650, 1635, 1600, 1585 cm-1

According to the analysis of related databases, 52311-20-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US5047411; (1991); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 52311-20-3, 2-Amino-4-ethoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Amino-4-ethoxypyridine, blongs to pyridine-derivatives compound. Safety of 2-Amino-4-ethoxypyridine

4-Ethoxy-pyridin-2-ylamine (15 g, 109 mmol) is dissolved in HOAc (100 mL) and cooled to 0 C. Bromine is added dropwise with vigorous stirring. The mixture is allowed to stir at RT for 30 minutes at which point a precipitate forms. The mixture is stirred for 30 min and the solids collected by filtration, washed with EtOAc in dried in a vacuum oven to give 5-bromo-4-ethoxy-pyridin-2-ylamine hydrobromide (23.3 g, 78.2 mmol).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,52311-20-3, 2-Amino-4-ethoxypyridine, and friends who are interested can also refer to it.

Reference:
Patent; Boehringer Ingelheim International GmbH; LIU, Pingrong; MILLER, Craig Andrew; YU, Maolin; ZHANG, Zhonghua; (93 pag.)US2018/72717; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem