Category: 52313-50-5

Application of 52313-50-5, Adding some certain compound to certain chemical reactions, such as: 52313-50-5, name is Picolinimidamide,molecular formula is C6H7N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52313-50-5.

A solution of 1-(2,4-difluorophenyl)piperidin-4-one (0.24 g, 1.14 mmol) and DMFDMA (0.5 mL) in acetonitrile (5 ml) was heated with stuffing at 90 C for 2 hrs. The mixture was concentrated in vacuo and the residue was dissolved in EtOH (lOmL). To the solution was addedpyridine-2-carboxamidine (91 mg, 0.75 mmol) and potassium carbonate (210 mg, L50 mmol) successively. After being heated at 90 C overnight, the resulting mixture was cooled to rt, diluted with water (20 mL) and extracted with EA (20 mL) for three times. The organic layers were washed with brine, dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by prep-HPLC to give 6-(2,4-difluorophenyl)-2-(2-pyridyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine (6 mg). ?H NMR (400MHz, DMSO-d6): oe 8.77 (s, 1H), 8.74 (d, 1H),8.36 (d, 1H), 7.97 (dt, 1H), 7.52 (ddd, 1H), 7.34 – 7.16 (m, 2H), 7.14 – 6.97 (m, 1H), 4.33 (s, 2H),3.48 (t, 2H), 3.10 (t, 2H). MS obsd. (ESIj [(M+H)]: 325.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 52313-50-5, Picolinimidamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHENG, Zhanling; WANG, Min; YANG, Song; (208 pag.)WO2016/107832; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 52313-50-5 ,Some common heterocyclic compound, 52313-50-5, molecular formula is C6H7N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 1-(4-benzyloxy-3-fluoro-phenyl)piperidin-4-one (4.17 g, 13.94 mmol) and DMFDMA (20 mL) in acetonitrile (10 mL) was heated with stirring at 90 C for 2 hrs. The resulting reaction mixture was concentrated in vacuo and the residue was dissolved in EtOH (40mL). To the solution was added pyridine-2-carboxamidine (1.8 g, 14.96 mmol) and potassium carbonate (4.1 g, 2992 mrnol) successively. After being heated with stirring at 90 C overnight, the resulting reaction mixture was cooled to rt, diluted with water (60 mL) and extracted with EA (30 mL) for three times. The combined organic layer was washed with brine, dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by columnchromatography (eluting with 5% MeOH in DCM) to give 6-(4-benzyloxy-3-fluoro-phenyl)-2-(2-pyridyl)-7 , 8-dihydro-5H-pyrido [4,3-d]pyrimidine (2.33 g). ?H NMR (400MHz, CDC13):8.96 – 8.85 (m, 1 H), 8.69 (s, 1 H), 8.53 (d, 1 H), 7.89 (t, 1 H), 7.52 – 7.32 (m, 6 H), 6.98 (t, 1 H),6.85 (dd, 1 H), 6.77 – 6.63 (m, 1 H), 5.12 (s, 2 H), 4.38 (s, 2 H), 3.61 (t, 2 H), 3.28 (t, 2 H). MSobsd. (ESf) [(M+H)]: 413.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 52313-50-5, Picolinimidamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHENG, Zhanling; WANG, Min; YANG, Song; (208 pag.)WO2016/107832; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 52313-50-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 52313-50-5, name is Picolinimidamide. A new synthetic method of this compound is introduced below.

General procedure: To a solution of 2-(4-methyl-2-(naphthalen-2-yl)thiazol-5-yl)-5-(methylsulfonyl)-1,3,4-oxadiazole(9) (0.09 g, 0.25 mmol) in dry DMF (5 mL), the appropriateamine, hydrazine, guanidine or carboxamidine (0.4 mmol) was added.The reaction mixture was heated at 80 C for 0.5-12 h, and then pouredon ice water (50 mL). The formed solid was extracted with ethyl acetate(10 mL). The organic layer was evaporated under reduced pressure. Theobtained crude material was then purified by column chromatography.Physical properties and spectral analysis of isolated products are listed below:

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,52313-50-5, its application will become more common.

Reference:
Article; Hannoun, Mohamed H.; Hagras, Mohamed; Kotb, Ahmed; El-Attar, Abdul-Aziz M.M.; Abulkhair, Hamada S.; Bioorganic Chemistry; vol. 94; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 52313-50-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 52313-50-5, name is Picolinimidamide. A new synthetic method of this compound is introduced below.

A mixture of N-methyl-4-(4-oxo-1-piperidyl)benzenesulfonamide (0.45 g, 1.67 mmol) andDMFDMA (2 mL) in acetonitrile (8 mL) was heated with stuffing at 90 C for 2 hrs. Theresulting reaction mixture was concentrated in vacuo and the residue was dissolved in EtOH (10 mL). To the solution was added pyridine-2-carboxamidine (0.15 g, 1.23 mmol) and potassium carbonate (034 g, 246 mrnol) successively. After being heated with stirring at 90 C overnight, the resulting reaction mixture was cooled to rt, diluted with water (20 mL) and extracted with EA (20 mL) for three times. The combined organic layer was washed with brine, dried overanhydrous Na2SO4 and concentrated in vacuo. The residue was purified by prep-PLC to give Nmethyl-4- [2- (2-pyridyl)-7 , 8-dihydro-5H-pyrido [4,3-d]pyrimidin-6-yl]benzenesulfonamide (7 mg). ?H NMR (400MHz, CDC13): oe 8.87 (d, 1H), 8.80 – 8.70 (m, 1H), 8.53 (d, 1H), 7.89 (dt, 1H), 7.80 (d, 2H), 7.44 (ddd, 1H), 7.06 – 6.97 (m, 2H), 4.63 (s, 2H), 3.86 (t, 2H), 3.32 (t, 2H), 2.67 (s, 3H). MS obsd. (ESIj [(M+H)?i: 382.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,52313-50-5, Picolinimidamide, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHENG, Zhanling; WANG, Min; YANG, Song; (208 pag.)WO2016/107832; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 52313-50-5, Picolinimidamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 52313-50-5, blongs to pyridine-derivatives compound. Safety of Picolinimidamide

Example 90 5-(2-Fluoro-4-methoxy-benzyl)-2-pyridin-2-yl-pyrimidine-4,6-diamine In a similar fashion using route 17 general procedure 55, pyridine-2-carboxamidine (100 mg, 0.83 mmol), 2-(2-fluoro-4-methoxy-benzyl)-malononitrile (186 mg, 0.91 mmol) and NaOMe (89 mg, 1.65 mmol) gave the title compound (14 mg, 5%) after purification by trituration from MeCN/Et2O.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,52313-50-5, its application will become more common.

Reference:
Patent; VIFOR (INTERNATIONAL) AG; US2012/202806; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52313-50-5, name is Picolinimidamide, molecular formula is C6H7N3, molecular weight is 121.14, as common compound, the synthetic route is as follows.COA of Formula: C6H7N3

Intermediate 108: ethyl 6-hvdroxy-2-(2-pyridinyl)-4-pyrimidinecarboxylateDiethyl 2-oxobutanedioate (4.31 mL, 26.6 mmol)(TCI Europe) was added to a suspension of 2- pyridinecarboximidamide (4.19 g, 26.6 mmol)(Alfa Aesar) in Ethanol (130 mL) at r.t. under nitrogen. Triethylamine (7.41 mL, 53.1 mmol) was added dropwise and the reaction mixture heated to 80 C and stirred for 24 h in total. The reaction was allowed to cool to r.t. and concentrated in vacuo to a black oil. The crude product was purified by column chromatography using a 0 to 100% solution of 20% MeOH in DCM/DCM to give the title product as a brown oil (2.91 g, 45% yield) which was used in the subsequent reaction without further purification.LCMS (Method A): Rt = 0.69 min, MH+ = 246.1

At the same time, in my other blogs, there are other synthetic methods of this type of compound,52313-50-5, Picolinimidamide, and friends who are interested can also refer to it.

Reference:
Patent; GLAXO GROUP LIMITED; ATKINSON, Stephen John; BARKER, Michael David; CAMPBELL, Matthew; HUMPHREYS, Philip; LIDDLE, John; SHEPPARD, Robert John; WILSON, David; WO2012/52390; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem