Category: 52334-81-3

52334-81-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52334-81-3, name is 2-Chloro-5-trifluoromethylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

Step 1; Preparation of 2-cyano-5-trifluoromethylpyridine; To 150ml N,N-dimethylformamide solution containing 15.0 g of 2-chloro-5-trifluoromethylpyridine were added 19.4 g of zinc cyanide and 9.6 g of tetrakistriphenylphosphine palladium, and the mixture was stirred under nitrogen atmosphere at 80C for 3 hours. After completion of the reaction, the reaction mixture was cooled to room temperature by allowing to stand, poured into 300 ml of dil. aqueous ammonia, and extracted with 300 ml of diethyl ether. The organic layer was washed with 200 ml of a saturated saline solution, then dried over anhydrous magnesium sulfate, the solvent was removed under reduced pressure, and the residue was purified by distillation under reduced pressure (96.0 to 99.0C/40 mmHg) to obtain 10.9 g of the the objective product as white crystals. Melting point: 36.0 to 38.0C 1H NMR (CDCl3, Me4Si, 300MHz) delta 9.00 (bs, 1H), 8.13 (dd, J=8.3, 2.1Hz, 1H), 7.87 (d, J=8.3Hz, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 52334-81-3, 2-Chloro-5-trifluoromethylpyridine.

Reference:
Patent; Nissan Chemical Industries, Ltd.; EP1671941; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52334-81-3, name is 2-Chloro-5-trifluoromethylpyridine, molecular formula is C6H3ClF3N, molecular weight is 181.54, as common compound, the synthetic route is as follows.52334-81-3

2-chloro-5-trifluoromethylpyridine (13.7 g) was dissolved in ethanol (96 ml), thiourea (5.7 g) was added to the mixture, and the mixture was heated to reflux for 3 hours. After allowing the mixture to be cooled to room temperature, an aqueous solution (19.2 ml) of potassium hydroxide (6.4 g) was added to the mixture, and the mixture was heated to reflux for 1 hour. After allowing the mixture to be cooled to room temperature, diluted aqueous solution of potassium hydroxide (20 ml) was added to the mixture, and the mixture was washed with methylene chloride. With acetic acid, pH of the mixture was adjusted to about 6, and the mixture was extracted with methylene chloride. The mixture was washed with water, and dried over magnesium sulfate. The solvent was removed under reduced pressure and the obtained residue was washed with hexane/ethyl acetate, to give 2-mercapto-5-trifluoromethylpyridine (5.1 g). 1H-NMR (200 MHz, CDCl3) delta 4.55 (2H, s), 7.25 to 7.50 (1H, s), 7.59 (2H, d, J = 8.8 Hz), 7.69 (1H, dd, J = 8.4, 2.2 Hz), 8.16 (2H, d, J = 8.8 Hz), 8.69 (1H, s)

Statistics shows that 52334-81-3 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-5-trifluoromethylpyridine.

Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1422228; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem