Category: 52471-07-5

Synthetic Route of 52471-07-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 52471-07-5, name is 2-Amino-6-chloronicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

A solution of 2-amino-6-chloronicotinonitrile (118.9 mg, 6.5 mmol) mg, DMAP (31.8 mg, 0.26 mmol) and TEA (988.4 mg, 9.8 mmol) in dichloromethane (15 mL) was added di-tert-butyl decarbonate (4263.5 mg, 19.5 mmol) at RT and the mixture was stirred at RT for 12 h. Sat. NaHCO3(15 mL) was added and the mixture was extracted with EtOAc (20 mL*2). The combined organic layers were dried with Na2SO4. After filtering, the solvent was concentrated under reduced pressure and the resultant residue was purified by column chromatography over silica gel (eluent: petrol ether/EtOAc=100:0 to 70:30). The desired fractions were collected and the solvent was removed to give a white solid (1500 mg, 90.8 mmol). LCMS (ESI) m/z M-55: 198.0.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 52471-07-5, 2-Amino-6-chloronicotinonitrile.

Reference:
Patent; Janssen Pharmaceutica NV; Lu, Tianbao; Connolly, Peter J.; Cummings, Maxwell David; Barbay, Joseph Kent; Kreutter, Kevin D.; Wu, Tongfei; Diels, Gaston Stanislas Marcella; Thuring, Jan Willem; Philippar, Ulrike; Edwards, James Patrick; Shen, Fang; (202 pag.)US2019/381019; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52471-07-5, name is 2-Amino-6-chloronicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H4ClN3

2-Amino-6-chlorinonicotinonitrile, purchased from ABLOCK PHARMATECH (2.0 g, 13.02 mmol) is dissolved in dry tetrahydrofurane (40 mL), copper (I) iodide (3.72 g, 19.54 mmol), diiodomethane (8.39 mL, 104.2 mmol) and tert-butyl nitrite (6.20 mL, 52.1 mmol) are added. Reaction mixture is refluxed for 1.5 h, cooled to RT and all volatiles are removed in vacuo. Obtained residue is dissolved in ethyl acetate (100 mL) and washed with 10% aqueous sodium thiosulfate solution (25 mL), saturated sodium hydrogen carbonate solution (25 mL), dried over MgSO4, filtered and concentrated in vacuo. The crude residue is purified by flash column chromatography to provide I-12.1 (eluent: petroleum ether/ethyl acetate). (0289) Yield 74%, m/z 265 [M+H]+, rt 0.90 min, LC-MS Method Z012_S04.

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Reference:
Patent; Boehringer Ingelheim International GmbH; VINTONYAK, Viktor; GRAUERT, Matthias; GRUNDL, Marc; PAUTSCH, Alexander; (64 pag.)US2016/75704; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem