In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52545-13-8, name is 4-Methoxypyridin-2(1H)-one, the common compound, a new synthetic route is introduced below. HPLC of Formula: C6H7NO2
To a stirred solution of 4-methoxy-1H-pyridin-2-one (Walters and Shay, Tetrahedron Letters 36 (1995), 7575) in methylene chloride (30 mL) at 0 C. is added triflic anhydride (12.9 g) followed by triethylamine (8.4 g). The reaction mixture is stirred for 20 min and then allowed to warm to room temperature. The volatile components are evaporated under vacuum and then the residue is dissolved in EtOAc and washed consecutively with aqueous sodium bicarbonate, water and brine solution. The organic phase is separated, dried and evaporated under vacuum to give trifluoro-methanesulfonic acid 4-methoxy-pyridin-2-yl ester. It is used in the next step without further purification.
The synthetic route of 52545-13-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hodgetts, Kevin J.; John, Stanly; Moorcroft, Neil; Shutske, Greg; Kaiser, Bernd; Yamaguchi, Yasuchika; Ge, Ping; Horvath, Raymond F.; US2005/70542; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem