Category: 52559-11-2

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52559-11-2, name is Pyridine-2,3,4-triamine, molecular formula is C5H8N4, molecular weight is 124.14, as common compound, the synthetic route is as follows.Safety of Pyridine-2,3,4-triamine

Dissolve 2,3, 4-triaminopyridine (2.5 mmol) in water (20 mL). Add NAHCO3 (0.63 g, 7.5 mmol), dioxane (10 ML), AND 2-BROMO-1-(3-TRIRLUOROMETHYL-PYRIDIN-2-YL)-ETHANONE hydrobromide (0.5 g) and stir at 100C for 2 hours. Cool the mixture and extract with EtOAc (4 X 10 mL). Wash the combined organic extracts with brine and dry over NA2S04. Purify the residue by preparative HPLC to give the title compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,52559-11-2, Pyridine-2,3,4-triamine, and friends who are interested can also refer to it.

Reference:
Patent; NEUROGEN CORPORATION; WO2005/7652; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 52559-11-2, name is Pyridine-2,3,4-triamine. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

2-(4-Nitro-phenyl)-3H-imidazo[4,5-c]pyridine-6-ylamine (8): 2,4,5 Triaminopyridine (6, 0.660 g, 5.32 mmol), p-nitro benzoic acid (7, 0.888 mg 5.32 mmol) was taken in PPA (30 g) and heated at 180 C. for 7 h. The reaction mixture was cooled to room temperature and poured on to crushed ice. The excess PPA was neutralized carefully by addition of solid K2CO3 portion wise (caution) till effervescence ceased. The brownish green precipitate was filtered and washed with water and dried. The solid was taken in (CH2Cl2: MeOH:THF:NH4OH 50:30:17:3) mixture and filtered (repeated the process 3-4 times). The solvents were removed and the nitro amine precipitated with EtOAc to give 8 (0.575 g, 56%). 1H NMR (DMSO-d6; 500 MHz): delta11.10 (1H, brs), 8.77 (1H, s), 8.45-8.25 (4H m), 6.50 (1H, s), 5.67 (2H, brs); EIMS m/z: 256.4 (M+1) and 290 (M+Cl-);

With the rapid development of chemical substances, we look forward to future research findings about 52559-11-2.

Reference:
Patent; Sircar, Jagadish C.; Thomas, Richard J.; Richards, Mark L.; Sinha, Anjana; US2004/116466; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 52559-11-2, name is Pyridine-2,3,4-triamine. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

2-(4-Nitro-phenyl)-3H-imidazo[4,5-c]pyridine-6-ylamine (8): 2,4,5 Triaminopyridine (6, 0.660 g, 5.32 mmol), p-nitro benzoic acid (7, 0.888 mg 5.32 mmol) was taken in PPA (30 g) and heated at 180 C. for 7 h. The reaction mixture was cooled to room temperature and poured on to crushed ice. The excess PPA was neutralized carefully by addition of solid K2CO3 portion wise (caution) till effervescence ceased. The brownish green precipitate was filtered and washed with water and dried. The solid was taken in (CH2Cl2: MeOH:THF:NH4OH 50:30:17:3) mixture and filtered (repeated the process 3-4 times). The solvents were removed and the nitro amine precipitated with EtOAc to give 8 (0.575 g, 56%). 1H NMR (DMSO-d6; 500 MHz): delta11.10 (1H, brs), 8.77 (1H, s), 8.45-8.25 (4H m), 6.50 (1H, s), 5.67 (2H, brs); EIMS m/z: 256.4 (M+1) and 290 (M+Cl-);

With the rapid development of chemical substances, we look forward to future research findings about 52559-11-2.

Reference:
Patent; Sircar, Jagadish C.; Thomas, Richard J.; Richards, Mark L.; Sinha, Anjana; US2004/116466; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52559-11-2, name is Pyridine-2,3,4-triamine, the common compound, a new synthetic route is introduced below. Computed Properties of C5H8N4

10. 6-(8-Amino-pyrido[2, S-typyrazinS-ytyS-trifluoromethyl-nicotinamide Dissolve 2,3,4-triaminopyridine (8 mmol) in water (20 mL). Add NaHCO3 (2.1 g, 25 mmol), dioxane (25 mL) and 6-(2-bromo-acetyl-5-trifluoromethyl)-nicotinamide (8 mmol), and stir at 100C for 4 hours. Cool the mixture and extract with EtOAc (4 x 10 mL). Wash the combined organic extracts with brine and dry over Na2SO4. Purify the residue by preparative HPLC to give the title compound.

The synthetic route of 52559-11-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NEUROGEN CORPORATION; WO2006/42289; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem