Preparation of some tricyclic fused ring iminopyrido[3,2-e]pyrimidines was written by Kwok, Russell. And the article was included in Journal of Heterocyclic Chemistry in 1978.Quality Control of 2-(Methylamino)nicotinonitrile This article mentions the following:
Iminopyridopyrimidines I [R = Me, PhCH2, Ph, m-(F3C)C6H4; n = 2, 3] were prepared Thus, treatment of 2-chloronicotinonitrile with primary amines gave 2-(alkylamino)-3-pyridinecarbonitriles which condensed with H2N(CH2)nNH2 to give cyclic amidines II. Treatment of II with BrCN gave I. The preparation of diaminopyrido[2,3-d]pyrimidines and tricyclic quinazolines by related procedures was discussed. In the experiment, the researchers used many compounds, for example, 2-(Methylamino)nicotinonitrile (cas: 52583-87-6Quality Control of 2-(Methylamino)nicotinonitrile).
2-(Methylamino)nicotinonitrile (cas: 52583-87-6) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Quality Control of 2-(Methylamino)nicotinonitrile