Category: 52605-96-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 52605-96-6, name is 2-Chloro-3-methoxypyridine. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Chloro-3-methoxypyridine

To a solution of Compound 8 (68 mg) in 2-propanol (5 ml) were added 2-chloro-3-methoxy pyridine (87 mg) and concentrated sulfuric acid (90 mg). It was stirred under reflux for 40 hours. Saturated sodium bicarbonate solution and water were added to the residue. The mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous magnesium sulfate. The solvent was evaporated in vacuo. The obtained residue was purified by column chromatography. The obtained solid was recrystallized with diethylether-hexane to give Compound 1-6 (25 mg).1H-NMR (CDCl3) delta: 1.58 (3H, s), 2.02-2.12 (1H, m), 2.33-2.42 (1H, m), 3.82-4.00 (3H, m), 3.89 (3H, s), 4.09-4.17 (1H, m), 6.67 (1H, dd, J=7.9, 5.0 Hz), 6.93-6.99 (2H, m), 7.01 (1H, brs), 7.34 (1H, dd, J=7.9, 3.0 Hz), 7.79 (1H, dd, J=5.0, 1.3 Hz), 8.02-8.08 (1H, m)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 52605-96-6, 2-Chloro-3-methoxypyridine.

Reference:
Patent; SHIONOGI & CO., LTD.; US2012/238557; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 52605-96-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52605-96-6, name is 2-Chloro-3-methoxypyridine, molecular formula is C6H6ClNO, molecular weight is 143.57, as common compound, the synthetic route is as follows.

The boronic acid was prepared as described in Intermediate 4 to give 2.8mmole. (quant. crude). The boronic acid (2. 14MMOL) was dissolved in acetonitrile (2. 4ML) and 3-methoxy-2-chloropyridine (368mg; 2. 6mmol) was added. After mixing, tetrakis palladium was added (25mg; 0. OLMOL%), follwed by 0. 8ml of water and K2CO3 (887mg; 6. 5MOL). The reaction mixture was heated at 160C in A Personal Chemistry EMRYS Microwave for 300S. After reaction completion, the solvents were evaporated and the residue was dissolved in EtOAc and washed with water and brine. The organic layer was dried over MGSO4, filtered and evaporated. The residue was then dissolved in A 1 : 1 mixture of THF/42NKOH and heated until saponification was complete. The basic layer was then extracted with EtOAc and acidified with cone. HCI. The aqueous layer was then extracted three times with EtOAc. The combined organic layers were dried over MGS04, filtered and evaporated to give the desired material as A yellow solid (425MG ; 76%). MS :MH+= 264

Statistics shows that 52605-96-6 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-3-methoxypyridine.

Reference:
Patent; RENOVIS, INC.; WO2005/32493; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52605-96-6, name is 2-Chloro-3-methoxypyridine, molecular formula is C6H6ClNO, molecular weight is 143.57, as common compound, the synthetic route is as follows.Computed Properties of C6H6ClNO

A three-necked flask was charged with Compound 1 (5.58 g, 39.0 mmol), N, N-dimethylformamide (60 mL) and sodium methoxide (6.20 g, 115.0 mmol); the reaction was stirred overnight at 60 C.The reaction was cooled to room temperature, water (120 mL) was added and extracted with ethyl acetate (80 mL x 3); the organic phases were combined, washed with water (100 mL x 2) and saturated brine (100 mL), dried over sodium sulfate, . The filtrate was spin-dried to give a yellow liquid, compound 2 (4.0 g, 28.9 mmol, 74%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,52605-96-6, 2-Chloro-3-methoxypyridine, and friends who are interested can also refer to it.

Reference:
Patent; Kanghua (Shanghai) Drug Discovery Co., Ltd.; Ma Jingxiang; (5 pag.)CN107286084; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 52605-96-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52605-96-6, name is 2-Chloro-3-methoxypyridine, molecular formula is C6H6ClNO, molecular weight is 143.57, as common compound, the synthetic route is as follows.

1) Preparation of 2-Hydrazino-3-methoxypyridine To 50 ml of a butanol solution of 9.376 g of 2-chloro-3-methoxypyridine were added 16 ml of hydrazine monohydrate and 9.03 g of anhydrous potassium carbonate, and the mixture was heated under reflux for 20 hours. After cooling, the reaction mixture was poured into 200 ml of water and extracted with a mixed solvent of methanol-chloroform (1:9 by volume). The organic layer was washed with a saturated sodium chloride aqueous solution, and dried over anhydrous sodium sulfate. The solvent was removed by evaporation. The residue was subjected to silica gel column chromatography using a mixture of chloroform-methanol (20:1 by volume) as an elude. The fraction containing the desired compound was concentrated to afford 5.952 g of the title compound. 1H-NMR (CDCl3) delta: 3.83 (s, 3H), 6.13 (br, 1H), 6.64 (dd, 1H, J=8, 5 Hz), 6.87 (dd, 1H, J=8, 1 Hz), 7.77 (dd, 1H, J=5, 1 Hz).

The chemical industry reduces the impact on the environment during synthesis 52605-96-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Daiichi Pharmaceutical Co., Ltd.; US6169086; (2001); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 52605-96-6, 2-Chloro-3-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C6H6ClNO, blongs to pyridine-derivatives compound. Computed Properties of C6H6ClNO

The 2-chloro-3-methoxypyridine (2) (13 g, 90.6 mmol), from Step I, was stirred with 3- equivalents of sodium methoxide (14.7 g, 271.8 mmol) in dimethylformamide (100 mL) at 10O0C until completion of the reaction. The reaction mixture was then quenched with water and extracted with dichloromethane. The combined extracts were washed with water, concentrated and distilled (74C; 5 mm Hg) to give the product, 2,3-dimethoxypyridine (3), as a clear oil (7 g; 29 % yield for two steps).1H NMR (300 MHz, CDCl3) delta 7.65 (dd, 1 H, Ji = 5.1 Hz, J2 = 1.5 Hz), 6.96(dd, 1 H, Ji = 7.5 Hz, J2 = 1.5 Hz), 6.76(dd, 1 H, J, = 5.1 Hz, J2 = 7.7 Hz), 3.95 (s, 3 H), 3.80 (s, 3 H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,52605-96-6, 2-Chloro-3-methoxypyridine, and friends who are interested can also refer to it.

Reference:
Patent; BIONUMERIK PHARMACEUTICALS, INC.; WO2007/123995; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 52605-96-6 ,Some common heterocyclic compound, 52605-96-6, molecular formula is C6H6ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-Chloro-3-methoxypyridine (1.22 g, 8.46 mmol) was dissolved in hydrazine hydrate (1 : 1) (10 ml) and stirred at reflux for 4 h. The reaction mixture was cooled to room temperature and evaporated. The residue was retaken in 10% methanol in chloroform and washed with an aqueous potassium carbonate solution. The aqueous phase was extracted with 10% methanol in chloroform . The combined organic layers were dried over magnesium sulfate and evaporated affording 781 mg (59% of th.) of the title compound. LC-MS (Method 6): Rt = 0.76 min; MS (ESIpos): m/z = 140 [M+H]+-NMR (400 MHz, DMSO-d6) delta [ppm] : 7.65 (dd, 1H), 7.09-6.87 (m, 2H), 6.56 (dd, 1H), 4.37- 3.85 (br. s, 2H), 3.76 (s, 3H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 52605-96-6, 2-Chloro-3-methoxypyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; COLLIN-KROePELIN, Marie-Pierre; KOLKHOF, Peter; NEUBAUER, Thomas; FUeRSTNER, Chantal; POOK, Elisabeth; TINEL, Hanna; SCHMECK, Carsten; WASNAIRE, Pierre; SCHIRMER, Heiko; LUSTIG, Klemens; (131 pag.)WO2019/81306; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem