Category: 52605-98-8

Application of 52605-98-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 52605-98-8, name is 5-Bromo-2,3-dimethoxypyridine, molecular formula is C7H8BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

As shown in step 2-v of Scheme 2, compound 1005 was suspended in 200 mL of dry THF along with PdCl2(Ph3P)2 (1.56 g, 2.23 mmol) and Ph3P (300 mg, 1.114 mmol). The mixture was flushed with N2 for 10 minutes. Triethylamine (14.0 mL, 10.14 g, 0.1 mol) and trimethylsilylacetylene (11.3 mL, 7.84 g, 0.080 mmol) were added under a nitrogen atmosphere and stirring continued for 15 minutes more before the addition of Cu(I) iodide (500 mg; 2.65 mmol). The reaction mixture was stirred at ambient temperature for 4 hours, and then heated for 5 hours at 40 C. under N2. The mixture was suction filtered through a pad of diatomaceous earth, which was washed with additional THF. The volatiles were removed under reduced pressure. The residue was dissolved in DCM, washed with water (2*), brine, and dried over Na2SO4. After filtration, the volatiles were removed under reduced pressure and the residue purified by silica gel chromatography (DCM) to provide 2,3-dimethoxy-5-((trimethylsilyl)ethynyl)pyridine (5.7 g) as a beige solid: ESMS (M+1)=236; 1H NMR (CDCl3) delta 7.89 (d, J=1.88 Hz, 1H), 7.1 (d, J=1.88 Hz, 1H), 4.02 (s, 3H), 3.89 (s, 3H), 0.12 (s, 9H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 52605-98-8, 5-Bromo-2,3-dimethoxypyridine.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; US2011/81316; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 52605-98-8, 5-Bromo-2,3-dimethoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H8BrNO2, blongs to pyridine-derivatives compound. Computed Properties of C7H8BrNO2

Add 2,3-dimethoxy-5-bromopyridine (218mg, 1.0mmol) to 5mL N, N-dimethylformamide solution, add cuprous cyanide (179.2mg, 4.0mmol), protect with argon Then, the temperature was raised to 160 C, and the reaction was completed after 8 hours of reaction. Cooled to room temperature, diluted with water, extracted with ethyl acetate, washed with saturated brine, dried over anhydrous sodium sulfate, concentrated to remove the solvent, and column chromatography (petroleum ether: ethyl acetate = 10: 1) to obtain the product 2,3- Dimethoxy-5-cyanopyridine (i.e. compound 16, 164.2 mg, 1.0 mmol), white solid, yield 50%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,52605-98-8, 5-Bromo-2,3-dimethoxypyridine, and friends who are interested can also refer to it.

Reference:
Patent; Zhiyuan Pharmaceutical (Qingyuan) Co., Ltd.; Wu Deyan; Xie Ying; Zhou Huifang; (24 pag.)CN110498784; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 52605-98-8, name is 5-Bromo-2,3-dimethoxypyridine. A new synthetic method of this compound is introduced below., HPLC of Formula: C7H8BrNO2

Step 2. N-(6-(5,6-dimethoxypyridin-3-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide Following the procedure described for N-(6-(6-chloro-5-(methylsulfonamido)pyridin-3-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide (Example 19), N-(6-chloroimidazo[1,2-b]pyridazin-2-yl)acetamide (0.132 g, 0.627 mmol) was reacted with bis(pinacolato)diboron (0.207 g, 0.815 mmol), DMSO (6.00 mL, 84.5 mmol) and potassium acetate (0.246 g, 2.51 mmol) and dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium (II) dichloromethane adduct (0.050 g, 0.062 mmol, Strem Chemical, Inc., Newburyport, Mass.) for 6 h.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 52605-98-8, 5-Bromo-2,3-dimethoxypyridine.

Reference:
Patent; Booker, Shon; Kim, Tae-Seong; Liao, Hongyu; Liu, Longbin; Norman, Mark H.; Peterson, Emily Anne; Stec, Markian; Tamayo, Nuria A.; US2009/163489; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 52605-98-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52605-98-8, name is 5-Bromo-2,3-dimethoxypyridine, molecular formula is C7H8BrNO2, molecular weight is 218.05, as common compound, the synthetic route is as follows.

5,6-Dimethoxynicotinaldehyde (42) To a solution of 5-bromo-2,3-dimethoxypyridine (41, 21.7 g, 99.5 mmol) in anhydrous tetrahydrofuran (200 mL) was dropwise added n-butyl lithium (48.0 mL, 2.5 mol/L in hexane) at -78 C. under N2. The mixture was stirred for at -78 C. for 1 h. Then N, N-dimethylformamide (16.2 mL) was added to the mixture at -78 C. The reaction mixture was stirred for another 30 min at -78 C. After the reaction was completed, the mixture was quenched by saturated NH4Cl(sat.), extracted with ethyl acetate, washed with brine, dried over anhydrous sodium sulfate and filtered. The filtrate was evaporated in vacuo. The residue was purified by flash chromatogram with ethyl acetate/petroleum ether (1:3) to afford 5,6-dimethoxynicotinaldehyde (42) as a yellow solid (13.5 g, 81%). ESI-MS, m/z=168 [M+H]+.

Statistics shows that 52605-98-8 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-2,3-dimethoxypyridine.

Reference:
Patent; Tsai, Guochuan Emil; Wang, Ching-Cheng; Hsieh, Yuan-Ting; (53 pag.)US2019/112289; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem